8081期

最新文章

• Supervised learning in DNA neural networks AI翻译
  作者：Cherry, Kevin M.; Qian, Lulu
  作者单位：California Institute of Technology; California Institute of Technology; California Institute of Technology
  摘要：Learning enables biological organisms to begin life simple yet develop immensely diverse and complex behaviours. Understanding learning principles in engineered molecular systems could enable us to endow non-living physical systems with similar capabilities. Inspired by how the brain processes information, the principles of neural computation have been developed over the past 80 years1, forming the foundation of modern machine learning. More than four decades ago, connections between neural co...
• Remodelling autoactive NLRs for broad-spectrum immunity in plants AI翻译
  作者：Wang, Junzhu; Chen, Tianyuan; Zhang, Zhendong; Song, Mengjie; Shen, Tianxin; Wang, Xin; Zheng, Xiyin; Wang, Yan; Song, Ke; Ge, Xiaoyang; Xu, Kai; Qi, Tiancong; Li, Fuguang; Hong, Yiguo; Liu, Yule
  作者单位：Tsinghua University; Tsinghua University; Tsinghua University; Chinese Academy of Agricultural Sciences; Institute of Cotton Research, CAAS; Nanjing Normal University; Hebei Agricultural University; Hebei Agricultural University; University of Warwick
  摘要：Remodelling plant immune receptors has become a vital strategy for creating new disease resistance traits to combat the growing threat of plant pathogens to global food security and environmental sustainability1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16-17. However, current methods are constrained by the rapid evolution of plant pathogens and often lack broad-spectrum and durable protection. Here we report an innovative strategy to engineer broad-spectrum, durable and complete diseas...
• Jelly-filled garment keeps wearers cool when heat and humidity soar AI翻译
  作者：[Anonymous]
• Does lithium deficiency contribute to Alzheimer's disease? AI翻译
  作者：Bush, Ashley I.
  作者单位：University of Melbourne; Florey Institute of Neuroscience & Mental Health; University of Melbourne
• First CRISPR horses spark controversy: what's next for gene-edited animals? AI翻译
  作者：Kavanagh, Katie
• RNA N-glycosylation enables immune evasion and homeostatic efferocytosis AI翻译
  作者：Graziano, Vincent R.; Porat, Jennifer; Ah Kioon, Marie Dominique; Mejdrova, Ivana; Matz, Alyssa J.; Lebedenko, Charlotta G.; Chai, Peiyuan; Pluvinage, John V.; Ricci-Azevedo, Rafael; Harrison, Andrew G.; Wright, Skylar S.; Wang, Xinzheng; Strine, Madison S.; Wang, Penghua; Wilson, Michael R.; Vanaja, Sivapriya Kailasan; Zhou, Beiyan; Barrat, Franck J.; Carell, Thomas; Flynn, Ryan A.; Rathinam, Vijay A.
  作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; University of Munich; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Yale University; University of Connecticut; Cornell University; Weill Cornell Medicine; Harvard University; Harvard University
  摘要：Glycosylation is central to the localization and function of biomolecules1. We recently discovered that small RNAs undergo N-glycosylation2 at the modified RNA base 3-(3-amino-3-carboxypropyl) uridine (acp3U)3. However, the functional significance of N-glycosylation of RNAs is unknown. Here we show that the N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs. We found that de-N-glycosylation of cell-culture-derived and circulating human and mouse glycoRNA elicited pot...
• Flourishing chemosynthetic life at the greatest depths of hadal trenches AI翻译
  作者：Peng, Xiaotong; Du, Mengran; Gebruk, Andrey; Liu, Shuangquan; Gao, Zhaoming; Glud, Ronnie N.; Zhou, Peng; Wang, Ruoheng; Rowden, Ashley A.; Kamenev, Gennady M.; Maiorova, Anastassya S.; Papineau, Dominic; Chen, Shun; Gao, Jinwei; Liu, Helu; He, Yuan; Alalykina, Inna L.; Dolmatov, Igor Yu.; Zhang, Hanyu; Li, Xuegong; Malyutina, Marina V.; Dasgupta, Shamik; Saulenko, Anastasiia A.; Shilov, Vladimir A.; Liu, Shuting; Xie, Tongtong; Qu, Yuangao; Song, Xikun; Zhang, Haibin; Liu, Hao; Zhang, Weijia; Huang, Xiaoxia; Xu, Hongzhou; Xu, Wenjing; Mordukhovich, Vladimir V.; Adrianov, Andrey V.
  作者单位：Chinese Academy of Sciences; Institute of Deep-Sea Science & Engineering, CAS; Russian Academy of Sciences; Shirshov Institute of Oceanology; University of Southern Denmark; National Institute of Water & Atmospheric Research (NIWA) - New Zealand; Victoria University Wellington; Russian Academy of Sciences; National Scientific Center of Marine Biology, Far East Branch of the Russian Academy of Sciences
  摘要：Hadal trenches, some of the Earth's least explored and understood environments, have long been proposed to harbour chemosynthesis-based communities1,2. Despite increasing attention, actual documentation of such communities has been exceptionally rare3,4. Here we report the discovery of the deepest and the most extensive chemosynthesis-based communities known to exist on Earth during an expedition to the Kuril-Kamchatka Trench and the western Aleutian Trench using the manned submersible Fendouz...
• Sweet like chocolate: researching in the shade of a cacao tree AI翻译
  作者：Brazil, Rachel; Ali, Naailah
  作者单位：University West Indies Mona Jamaica; University West Indies Saint Augustine
• AIR POLLUTION DIRECTLY LINKED TO INCREASED DEMENTIA RISK AI翻译
  作者：Fieldhouse, Rachel
• How did assaults on science become the norm - and what can we do? AI翻译
  作者：Goldman, Gretchen T.