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作者：Goldstone, Jack A.
作者单位：George Mason University
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作者：Zapperi, Stefano; Varlet-Bertrand, Constant; Bastidon, Cecile; La Porta, Caterina A. M.; Parent, Antoine
作者单位：University of Milan; Consiglio Nazionale delle Ricerche (CNR); Istituto di Chimica della Materia Condensata e di Tecnologie per l Energia (ICMATE-CNR); Universite Paris-VIII; Ecole Normale Superieure de Lyon (ENS de LYON); Universite de Toulon; Institut d'Etudes Politiques Paris (Sciences Po); University of Milan; IRCCS Ca Granda Ospedale Maggiore Policlinico
摘要：The Great Fear of 1789, a wave of panic and unrest in rural France fuelled by the spreading of rumours, was an important moment at the onset of the French Revolution, marking the collapse of feudalism and the rise of the new regime1. The Great Fear provides a vivid example of the role the spreading of rumours has in driving political changes that might be relevant today2,3. Here, we collect existing historical records related to the Great Fear and use epidemiology tools and models4 to reconstr...
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作者：Iglesias-Artola, Juan M.; Boehlig, Kristin; Schuhmann, Kai; Cook, Katelyn C.; Lennartz, H. Mathilda; Schuhmacher, Milena; Barahtjan, Pavel; Lopez, Cristina Jimenez; Sachl, Radek; Garikapati, Vannuruswamy; Pombo-Garcia, Karina; Lohmann, Annett; Riegerova, Petra; Hof, Martin; Drobot, Bjorn; Shevchenko, Andrej; Honigmann, Alf; Nadler, Andre
作者单位：Max Planck Society; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Czech Academy of Sciences; J. Heyrovsky Institute of Physical Chemistry of the Czech Academy of Sciences; Helmholtz Association; Helmholtz-Zentrum Dresden-Rossendorf (HZDR); Technische Universitat Dresden; Technische Universitat Dresden
摘要：Eukaryotic cells produce over 1,000 different lipid species that tune organelle membrane properties, control signalling and store energy1,2. How lipid species are selectively sorted between organelles to maintain specific membrane identities is largely unclear, owing to the difficulty of imaging lipid transport in cells3. Here we measured the retrograde transport and metabolism of individual lipid species in mammalian cells using time-resolved fluorescence imaging of bifunctional lipid probes ...
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作者：Hutson, Matthew
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作者：Zaporski, Leon; Liu, Qi; Velez, Gustavo; Radzihovsky, Matthew; Li, Zeyang; Colombo, Simone; Pedrozo-Penafiel, Edwin; Vuletic, Vladan
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Stanford University; University of Connecticut; State University System of Florida; University of Florida
摘要：Optical lattice clocks are at the forefront of precision metrology1, 2, 3, 4, 5-6, operating near a standard quantum limit set by quantum noise4,7. Harnessing quantum entanglement offers a promising route to surpass this limit8, 9, 10, 11, 12, 13, 14-15; however, there are practical difficulties in terms of scalability and measurement resolution requirements16,17. Here we adapt the holonomic quantum gate concept18 to develop a new Rabi-type 'global-phase spectroscopy' that uses the detuning-se...
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作者：Song, Tianqi; Qian, Lulu
作者单位：California Institute of Technology; California Institute of Technology; California Institute of Technology
摘要：Metabolism enables life to sustain dynamics and to repeatedly interact with the environment by storing and consuming chemical energy. A major challenge for artificial molecular machines is to find a universal energy source akin to ATP for biological organisms and electricity for electromechanical machines. More than 20 years ago, DNA was first used as fuel to drive nanomechanical devices1,2 and catalytic reactions3. However, each system requires distinct fuel sequences, preventing DNA alone fr...
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作者：Kalantzakos, Sophia
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作者：Clements, Melanie; Tang, Wenhao; Florjanic Baronik, Zan; Simpson Ragdale, Holly; Oria, Roger; Volteras, Dimitrios; White, Ian J.; Beattie, Gordon; Uddin, Imran; Lenn, Tchern; Lindsay, Rachel; Castro Devesa, Sara; Karamched, Saketh R.; Lythgoe, Mark F.; Shahrezaei, Vahid; Weaver, Valerie M.; Sugisawa, Ryoichi; Roncaroli, Federico; Marguerat, Samuel; Hill, Ciaran S.; Parrinello, Simona
作者单位：University of London; University College London; Imperial College London; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of London; University College London; University of London; University College London; University of London; University College London; University of London; University College London; University of London; University College London; University of London; University College London; University of California System; University of California San Francisco; Kindai University (Kinki University); University of Manchester; University College London Hospitals NHS Foundation Trust; University of London; National Hospital for Neurology & Neurosurgery; University College London; UCL Medical School
摘要：Glioblastoma (GBM) is an aggressive and highly therapy-resistant brain tumour1,2. Although advanced disease has been intensely investigated, the mechanisms that underpin the earlier, likely more tractable, stages of GBM development remain poorly understood. Here we identify axonal injury as a key driver of GBM progression, which we find is induced in white matter by early tumour cells preferentially expanding in this region. Mechanistically, axonal injury promotes gliomagenesis by triggering W...
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作者：Shen, Qian; Wang, Hao; Roco, Jonathan A.; Meng, Xiangpeng; Bosticardo, Marita; Hodges, Marie; Battaglia, Michael; Feng, Zhi-Ping; Talks, Benjamin James; Powell, Jason; Shanmugiah, Vijaya Baskar Mahalingam; Chu, Julia; Rahman, Najib M.; Elsheikh, Alguili; Chakravarty, Probir; Grenov, Amalie; Emmerich, Max; Delmonte, Ottavia M.; Freeman, Alexandra F.; Keller, Michael D.; Belaid, Brahim; Papa, Ilenia; Lee, James C.; Canete, Pablo F.; Gonzalez-Figueroa, Paula; Zhang, Yaoyuan; Xue, Hai-Hui; Turajlic, Samra; Notarangelo, Luigi D.; Haniffa, Muzlifah; Garrett-Sinha, Lee Ann; Parry, Helen M.; Kanellakis, Nikolaos I.; Vinuesa, Carola G.
作者单位：Francis Crick Institute; Australian National University; John Curtin School of Medical Research; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); University of Birmingham; State University of New York (SUNY) System; University at Buffalo, SUNY; Australian National University; John Curtin School of Medical Research; Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust; Newcastle University - UK; Wellcome Trust Sanger Institute; University of Oxford; Chinese Academy of Medical Sciences - Peking Union Medical College; University of Oxford; Oxford University Hospitals NHS Foundation Trust; Royal Marsden NHS Foundation Trust; Children's National Health System; University of Queensland; University of Queensland; Hackensack University Medical Center
摘要：B-1 cells are innate-like immune cells abundant in serosal cavities with antibodies enriched in bacterial recognition, yet their existence in humans has been controversial1, 2-3. The CD5+ B-1a subset expresses anti-inflammatory molecules including IL-10, PDL1 and CTLA4 and can be immunoregulatory4, 5-6. Unlike conventional B cells that are continuously replenished, B-1a cells are produced early in life and maintained through self-renewal7. Here we show that the transcription factors TCF1 and L...
