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作者：[Anonymous]
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作者：Wang, Dashun
作者单位：Northwestern University
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作者：Hakim, Budianto; Wibowo, Unggul Prasetyo; van den Bergh, Gerrit D.; Yurnaldi, Dida; Joannes-Boyau, Renaud; Duli, Akin; Suryatman; Sardi, Ratno; Nurani, Indah Asikin; Puspaningrum, Mika Rizki; Mahmud, Irfan; Haris, Afdalah; Al Anshari, Khairun; Saiful, Andi Muhammad; Arman Bungaran, P.; Adhityatama, Shinatria; Muhammad, Putra Hudlinas; Akib, Anwar; Somba, Nani; Fakhri; Burhan, Basran; Mas'ud, Zubair; Moore, Mark W.; Perston, Yinika L.; Yu, Wenjing; Aubert, Maxime; Brumm, Adam
作者单位：National Research & Innovation Agency of Indonesia (BRIN); Universitas Hasanuddin; University of Wollongong; Southern Cross University; Universitas Hasanuddin; Institute Technology of Bandung; Griffith University; Griffith University; University of New England; Griffith University
摘要：The dispersal of archaic hominins beyond mainland Southeast Asia (Sunda)1 represents the earliest evidence for humans crossing ocean barriers to reach isolated landmasses2, 3-4. Previously, the oldest indication of hominins in Wallacea, the oceanic island zone east of Sunda, comprised flaked stone artefacts deposited at least 1.02 +/- 0.02 million years ago (Ma) at Wolo Sege on Flores5. Early hominins were also established on the oceanic island of Luzon (Philippines), as indicated by both ston...
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作者：[Anonymous]
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作者：Di Cosmo, Roberto; Granger, Sabrina; Hinsen, Konrad; Jullien, Nicolas; Le Berre, Daniel; Louvet, Violaine; Maumet, Camille; Maurice, Clementine; Monat, Raphael; Rougier, Nicolas P.
作者单位：IMT - Institut Mines-Telecom; IMT Atlantique; Universite de Rennes; Universite de Lille; Centre National de la Recherche Scientifique (CNRS); Universite de Lille; Universite de Bordeaux; Inria
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作者：Salay, Lindsey D.; Tsao, Doris Y.; Anderson, David J.
作者单位：California Institute of Technology; California Institute of Technology; Howard Hughes Medical Institute; University of California System; University of California Berkeley
摘要：Internal motive states, such as sexual arousal, drive behaviour in response to social cues. However, little is known about how internal states and external cues are integrated to release appropriate behaviours at the correct moment during a social interaction, such as the transition from the appetitive to the consummatory phases of mating1,2. Here we identify a neural circuit in male mice that gates the onset of consummatory reproductive behaviours on contact with a mating partner. Stimulating...
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作者：Nordling, Linda
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作者：Bourzac, Katherine
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作者：Valenstein, Max L.; Wranik, Maximilian; Lalgudi, Pranav V.; Linde-Garelli, Karen Y.; Choi, Yuri; Chivukula, Raghu R.; Sabatini, David M.; Rogala, Kacper B.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Massachusetts Institute of Technology (MIT); Whitehead Institute; Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School; Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; Stanford Cancer Institute; Stanford University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Czech Academy of Sciences; Institute of Organic Chemistry & Biochemistry of the Czech Academy of Sciences
摘要：The mechanistic target of rapamycin complex 1 (mTORC1) anchors a conserved signalling pathway that regulates growth in response to nutrient availability1, 2, 3, 4-5. Amino acids activate mTORC1 through the Rag GTPases, which are regulated by GATOR, a supercomplex consisting of GATOR1, KICSTOR and the nutrient-sensing hub GATOR2 (refs. 6, 7, 8-9). GATOR2 forms an octagonal cage, with its distinct WD40 domain beta-propellers interacting with GATOR1 and the leucine sensors Sestrin1 and Sestrin2 (...
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作者：Kozlov, Max
