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作者：You, Xiaoying
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作者：Zhou, Hengyun; Zhao, Chen; Cain, Madelyn; Bluvstein, Dolev; Maskara, Nishad; Duckering, Casey; Hu, Hong-Ye; Wang, Sheng-Tao; Kubica, Aleksander; Lukin, Mikhail D.
作者单位：Harvard University; California Institute of Technology; Yale University
摘要：Fast, reliable logical operations are essential for realizing useful quantum computers1, 2-3. By redundantly encoding logical qubits into many physical qubits and using syndrome measurements to detect and correct errors, we can achieve low logical error rates. However, for many practical quantum error correction codes such as the surface code, owing to syndrome measurement errors, standard constructions require multiple extraction rounds-of the order of the code distance d-for fault-tolerant c...
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作者：Purcell, Jessica
作者单位：University of California System; University of California Riverside
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作者：Forrester, Nikki; Mukherjee, Jenia
作者单位：Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kharagpur
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作者：Pacesa, Martin; Nickel, Lennart; Schellhaas, Christian; Schmidt, Joseph; Pyatova, Ekaterina; Kissling, Lucas; Barendse, Patrick; Choudhury, Jagrity; Kapoor, Srajan; Alcaraz-Serna, Ana; Cho, Yehlin; Ghamary, Kourosh H.; Vinue, Laura; Yachnin, Brahm J.; Wollacott, Andrew M.; Buckley, Stephen; Westphal, Adrie H.; Lindhoud, Simon; Georgeon, Sandrine; Goverde, Casper A.; Hatzopoulos, Georgios N.; Gonczy, Pierre; Muller, Yannick D.; Schwank, Gerald; Swarts, Daan C.; Vecchio, Alex J.; Schneider, Bernard L.; Ovchinnikov, Sergey; Correia, Bruno E.
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Institute of Bioinformatics; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Zurich; Wageningen University & Research; State University of New York (SUNY) System; University at Buffalo, SUNY; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University of Lausanne; Massachusetts Institute of Technology (MIT); Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Swiss Institute Experimental Cancer Research; Ecole Polytechnique Federale de Lausanne
摘要：Protein-protein interactions are at the core of all key biological processes. However, the complexity of the structural features that determine protein-protein interactions makes their design challenging. Here we present BindCraft, an open-source and automated pipeline for de novo protein binder design with experimental success rates of 10-100%. BindCraft leverages the weights of AlphaFold2 (ref. 1) to generate binders with nanomolar affinity without the need for high-throughput screening or e...
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作者：[Anonymous]
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作者：Juve, Y.; Lutrat, C.; Ha, A.; Weyna, A.; Lauroua, E.; Silva, A. C. Afonso; Roux, C.; Schifani, E.; Galkowski, C.; Lebas, C.; Allio, R.; Stoyanov, I.; Galtier, N.; Schlick-Steiner, B. C.; Steiner, F. M.; Baas, D.; Kaufmann, B.; Romiguier, J.
作者单位：Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; University of Lausanne; Universite de Lille; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); University of Parma; Consejo Superior de Investigaciones Cientificas (CSIC); Pompeu Fabra University; CSIC-UPF - Institut de Biologia Evolutiva (IBE); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; INRAE; CIRAD; Institut Agro; Institut Agro Montpellier; Plovdiv University; University of Innsbruck; Universite Lyon 1; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Universite Lyon 1; CNRS - Institute of Ecology & Environment (INEE)
摘要：Living organisms are assumed to produce same-species offspring1,2. Here, we report a shift from this norm in Messor ibericus, an ant that lays individuals from two distinct species. In this life cycle, females must clone males of another species because they require their sperm to produce the worker caste. As a result, males from the same mother exhibit distinct genomes and morphologies, as they belong to species that diverged over 5 million years ago. The evolutionary history of this system a...
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作者：Middleton, Steven J.; Markusson, Sigurbjorn; Akerlund, Mikael; Deme, Justin C.; Tseng, Mandy; Li, Wenqianglong; Zuberi, Sana R.; Kuteyi, Gabriel; Sarkies, Peter; Baskozos, Georgios; Perez-Sanchez, Jimena; Farah, Adham; Hebert, Harry L.; Toikumo, Sylvanus; Yu, Zhanru; Maxwell, Susan; Dong, Yin Y.; Kessler, Benedikt M.; Kranzler, Henry R.; Linley, John E.; Smith, Blair H.; Lea, Susan M.; Parker, Joanne L.; Lyssenko, Valeriya; Newstead, Simon; Bennett, David L.
作者单位：University of Oxford; University of Oxford; University of Oxford; Lund University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); University of Dundee; University of Dundee; University of Pennsylvania; Pennsylvania Medicine; University of Oxford; Chinese Academy of Medical Sciences - Peking Union Medical College; University of Oxford; AstraZeneca; University of Bergen; Steno Diabetes Center
摘要：Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy1. They are implicated in multiple neurological disorders, including stroke, epilepsy and neurodegeneration, and can regulate neuronal excitability through interactions with ion channels2. Polyamines have been linked to pain, showing altered levels in human persistent pain states and modulation of pain behaviour in animal models3. However, the systems governing polyamine transport w...
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作者：Linares-Otoya, Luis; Shirkey, Jaden D.; Chhetri, Bhuwan Khatri; Mira, Amira; Biswas, Abhishek; Neff, Samuel L.; Linares-Otoya, Maria V.; Chen, Ye; Campos-Florian, Julio V.; Ganoza-Yupanqui, Mayar L.; Jeffrey, Philip D.; Hughson, Frederick M.; Donia, Mohamed S.
作者单位：Princeton University; Universidad Nacional de Trujillo; Egyptian Knowledge Bank (EKB); Mansoura University; Princeton University; Princeton University; Princeton University
摘要：Considerable advances have been made in characterizing bioactive molecules secreted by bacteria, yet the regulatory elements controlling their production remain largely understudied. Here we identify and characterize the N-acyl-cyclolysine (ACL) system-a cell-density-dependent chemical signalling system specific to and widespread in the phylum Bacteroidota (formerly Bacteroidetes)-and show that it regulates the expression of co-localized operons encoding diverse secreted molecules. Using genet...
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作者：Cui, Jirong; Zou, Ren; Zhang, Weijin; Wen, Hong; Liu, Jinyao; Wang, Shangshang; Liu, Shukun; Chen, Hetong; Liu, Wei; Ju, Xiaohua; Wang, Weiwei; Gan, Tao; Li, Jiong; Guo, Jianping; He, Teng; Cao, Hujun; Chen, Ping
作者单位：Chinese Academy of Sciences; Dalian Institute of Chemical Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Jilin University; Chinese Academy of Sciences; Shanghai Advanced Research Institute, CAS; Chinese Academy of Sciences
摘要：As a negative charge carrier, the hydride ion (H-) is more energetic, polarizable and reactive than cations1. An H--mediated electrochemical process is fundamentally different from existing systems and enables the development of innovative electrochemical devices, such as rechargeable batteries, fuel cells, electrolysis cells and gas separation membranes2. Here we developed a core-shell hydride 3CeH3@BaH2, which exhibits fast H- conduction at ambient temperature and becomes a superionic conduc...
