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作者：Willyard, Cassandra
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作者：Audard, Marc; Awaki, Hisamitsu; Ballhausen, Ralf; Bamba, Aya; Behar, Ehud; Boissay-Malaquin, Rozenn; Brenneman, Laura; Brown, Gregory V.; Corrales, Lia; Costantini, Elisa; Cumbee, Renata; Trigo, Maria Diaz; Done, Chris; Dotani, Tadayasu; Ebisawa, Ken; Eckart, Megan; Eckert, Dominique; Enoto, Teruaki; Eguchi, Satoshi; Ezoe, Yuichiro; Foster, Adam; Fujimoto, Ryuichi; Fujita, Yutaka; Fukazawa, Yasushi; Fukushima, Kotaro; Furuzawa, Akihiro; Gallo, Luigi; Garcia, Javier A.; Gu, Liyi; Guainazzi, Matteo; Hagino, Kouichi; Hamaguchi, Kenji; Hatsukade, Isamu; Hayashi, Katsuhiro; Hayashi, Takayuki; Hell, Natalie; Hodges-Kluck, Edmund; Hornschemeier, Ann; Ichinohe, Yuto; Ishida, Manabu; Ishikawa, Kumi; Ishisaki, Yoshitaka; Kaastra, Jelle; Kallman, Timothy; Kara, Erin; Katsuda, Satoru; Kanemaru, Yoshiaki; Kelley, Richard; Kilbourne, Caroline; Kitamoto, Shunji; Kobayashi, Shogo; Kohmura, Takayoshi; Kubota, Aya; Leutenegger, Maurice; Loewenstein, Michael; Maeda, Yoshitomo; Markevitch, Maxim; Matsumoto, Hironori; Matsushita, Kyoko; Mccammon, Dan; Mcnamara, Brian; Mernier, Francois; Miller, Eric D.; Miller, Jon M.; Mitsuishi, Ikuyuki; Mizumoto, Misaki; Mizuno, Tsunefumi; Mori, Koji; Mukai, Koji; Murakami, Hiroshi; Mushotzky, Richard; Nakajima, Hiroshi; Nakazawa, Kazuhiro; Ness, Jan-Uwe; Nobukawa, Kumiko; Nobukawa, Masayoshi; Noda, Hirofumi; Odaka, Hirokazu; Ogawa, Shoji; Ogorzalek, Anna; Okajima, Takashi; Ota, Naomi; Paltani, Stephane; Petre, Robert; Plucinsky, Paul; Porter, Frederick Scott; Pottschmidt, Katja; Sato, Kosuke; Sato, Toshiki; Sawada, Makoto; Seta, Hiromi; Shidatsu, Megumi; Simionescu, Aurora; Smith, Randall; Suzuki, Hiromasa; Szymkowiak, Andrew; Takahashi, Hiromitsu; Takeo, Mai; Tamagawa, Toru; Tamura, Keisuke; Tanaka, Takaaki; Tanimoto, Atsushi; Tashiro, Makoto; Terada, Yukikatsu; Terashima, Yuichi; Tsuboi, Yohko; Tsujimoto, Masahiro; Tsunemi, Hiroshi; Tsuru, Takeshi G.; Uchida, Hiroyuki; Uchida, Nagomi; Uchida, Yuusuke; Uchiyama, Hideki; Ueda, Yoshihiro; Uno, Shinichiro; Vink, Jacco; Watanabe, Shin; Williams, Brian J.; Yamada, Satoshi; Yamada, Shinya; Yamaguchi, Hiroya; Yamaoka, Kazutaka; Yamasaki, Noriko; Yamauchi, Makoto; Yamauchi, Shigeo; Yaqoob, Tahir; Yoneyama, Tomokage; Yoshida, Tessei; Yukita, Mihoko; Zhuravleva, Irina; Braito, Valentina; Condo, Pierpaolo; Fukumura, Keigo; Gonzalez, Adam; Luminari, Alfredo; Miyamoto, Aiko; Mizukawa, Ryuki; Reeves, James; Sato, Riki; Tombesi, Francesco; Xu, Yerong
作者单位：University of Geneva; Ehime University; University System of Maryland; University of Maryland College Park; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; University of Tokyo; Technion Israel Institute of Technology; Massachusetts Institute of Technology (MIT); University System of Maryland; University of Maryland Baltimore County; Smithsonian Institution; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; University of Michigan System; University of Michigan; Durham University; University of Tokyo; Japan Aerospace Exploration Agency (JAXA); Institute of Space & Astronautical Science (ISAS); Kyoto University; Tokyo Metropolitan University; Hiroshima University; Fujita Health University; Saint Marys University - Canada; California Institute of Technology; European Space Agency; European Space Research & Technology Centre; University of Miyazaki; RIKEN; Leiden University; Leiden University - Excl LUMC; Saitama University; Rikkyo University; Tokyo University of Science; Tokyo University of Science; Shibaura Institute of Technology; University of Osaka; University of Wisconsin System; University of Wisconsin Madison; University of Waterloo; Nagoya University; Hiroshima University; Tohoku Gakuin University; Kanto Gakuin University; European Space Agency; European Space Astronomy Center; Kindai University (Kinki University); Nara University Education; Tohoku University; Nara Womens University; Kyoto Sangyo University; Meiji University; Yale University; Konan University; Kagoshima University; Chuo University; Shizuoka University; Kyoto University; University of Amsterdam; Johns Hopkins University; University of Chicago; Istituto Nazionale Astrofisica (INAF); Catholic University of America; University of Trento; University of Rome Tor Vergata; James Madison University; Istituto Nazionale Astrofisica (INAF); Istituto Nazionale Astrofisica (INAF)
摘要：Evidence indicates that supermassive black holes (SMBHs) exist at the centres of most galaxies. Their mass correlates with the galactic bulge mass1, suggesting a coevolution with their host galaxies2, most likely through powerful winds3. X-ray observations have detected highly ionized winds outflowing at sub-relativistic speeds from the accretion disks around SMBHs4,5. However, the limited spectral resolution of present X-ray instruments has left the physical structure and location of the wind...
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作者：Castelvecchi, Davide
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作者：Hatzikotoulas, Konstantinos; Southam, Lorraine; Stefansdottir, Lilja; Boer, Cindy G.; Mcdonald, Merry-Lynn; Pett, J. Patrick; Park, Young-Chan; Tuerlings, Margo; Mulders, Rick; Barysenka, Andrei; Arruda, Ana Luiza; Tragante, Vinicius; Rocco, Alison; Bittner, Norbert; Chen, Shibo; Horn, Susanne; Srinivasasainagendra, Vinodh; To, Ken; Katsoula, Georgia; Kreitmaier, Peter; Tenghe, Amabel M. M.; Gilly, Arthur; Arbeeva, Liubov; Chen, Lane G.; de Pins, Agathe M.; Dochtermann, Daniel; Henkel, Cecilie; Hoeijer, Jonas; Ito, Shuji; Lind, Penelope A.; Lukusa-Sawalena, Bitota; Minn, Aye Ko Ko; Mola-Caminal, Marina; Narita, Akira; Nguyen, Chelsea; Reimann, Ene; Silberstein, Micah D.; Skogholt, Anne-Heidi; Tiwari, Hemant K.; Yau, Michelle S.; Yue, Ming; Zhao, Wei; Zhou, Jin J.; Alexiadis, George; Banasik, Karina; Brunak, Soren; Campbell, Archie; Cheung, Jackson T. S.; Dowsett, Joseph; Faquih, Tariq; Faul, Jessica D.; Fei, Lijiang; Fenstad, Anne Marie; Funayama, Takamitsu; Gabrielsen, Maiken E.; Gocho, Chinatsu; Gromov, Kirill; Hansen, Thomas; Hudjashov, Georgi; Ingvarsson, Thorvaldur; Johnson, Jessica S.; Jonsson, Helgi; Kakehi, Saori; Karjalainen, Juha; Kasbohm, Elisa; Lemmelae, Susanna; Lin, Kuang; Liu, Xiaoxi; Loef, Marieke; Mangino, Massimo; Mccartney, Daniel; Millwood, Iona Y.; Richman, Joshua; Roberts, Mary B.; Ryan, Kathleen A.; Samartzis, Dino; Shivakumar, Manu; Skou, Soren T.; Sugimoto, Sachiyo; Suzuki, Ken; Takuwa, Hiroshi; Teder-Laving, Maris; Thomas, Laurent; Tomizuka, Kohei; Turman, Constance; Weiss, Stefan; Wu, Tian T.; Zengini, Eleni; Zhang, Yanfei; Babis, George; van Heel, David A.; Winsvold, Bendik; Gabrielsen, Maiken; Ferreira, Manuel Allen Revez; Baras, Aris; Barker, Tyler; Carey, David J.; Cheah, Kathryn S. E.; Chen, Zhengming; Cheung, Jason Pui-Yin; Daly, Mark; de Mutsert, Renee; Eaton, Charles B.; Erikstrup, Christian; Furnes, Ove Nord; Golightly, Yvonne M.; Gudbjartsson, Daniel F.; Hailer, Nils P.; Hayward, Caroline; Hochberg, Marc C.; Homuth, Georg; Huckins, Laura M.; Hveem, Kristian; Ikegawa, Shiro; Ishijima, Muneaki; Isomura, Minoru; Jones, Marcus; Kang, Jae H.; Kardia, Sharon L. R.; Kloppenburg, Margreet; Kraft, Peter; Kumahashi, Nobuyuki; Kuwata, Suguru; Lee, Ming Ta Michael; Lee, Phil H.; Lerner, Robin; Li, Liming; Lietman, Steve A.; Lotta, Luca; Lupton, Michelle K.; Maegi, Reedik; Martin, Nicholas G.; Mcalindon, Timothy E.; Medland, Sarah E.; Michaelsson, Karl; Mitchell, Braxton D.; Mook-Kanamori, Dennis O.; Morris, Andrew P.; Nabika, Toru; Nagami, Fuji; Nelson, Amanda E.; Ostrowski, Sisse Rye; Palotie, Aarno; Pedersen, Ole Birger; Rosendaal, Frits R.; Sakurai-Yageta, Mika; Schmidt, Carsten Oliver; Sham, Pak Chung; Singh, Jasvinder A.; Smelser, Diane T.; Smith, Jennifer A.; Song, You-qiang; Sorensen, Erik; Tamiya, Gen; Tamura, Yoshifumi; Terao, Chikashi; Thorleifsson, Gudmar; Troelsen, Anders; Tsezou, Aspasia; Uchio, Yuji; Uitterlinden, A. G.; Ullum, Henrik; Valdes, Ana M.; Walters, Robin G.; Weir, David R.; Wilkinson, J. Mark; Winsvold, Bendik S.; Yamamoto, Masayuki; Zwart, John-Anker; Stefansson, Kari; Meulenbelt, Ingrid; Teichmann, Sarah A.; van Meurs, Joyce B. J.; Styrkarsdottir, Unnur; Zeggini, Eleftheria
作者单位：Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Decode Genetics; Erasmus University Rotterdam; Erasmus MC; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; Wellcome Trust Sanger Institute; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); University of Alabama System; University of Alabama Birmingham; University of Cambridge; University of Cambridge; Eberhard Karls University of Tubingen; Regeneron; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Hong Kong; Icahn School of Medicine at Mount Sinai; University of Copenhagen; Uppsala University; Shimane University; RIKEN; RIKEN; QIMR Berghofer Medical Research Institute; University of Queensland; Queensland University of Technology (QUT); Tohoku University; Tohoku University; University of Tartu; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Norwegian University of Science & Technology (NTNU); Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Hebrew SeniorLife; University of Hong Kong; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of California System; University of California Los Angeles; University of Copenhagen; University of Edinburgh; Imperial College London; Rigshospitalet; University of Copenhagen; Copenhagen University Hospital; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; University of Bergen; Haukeland University Hospital; University of Copenhagen; University of Iceland; Icahn School of Medicine at Mount Sinai; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Juntendo University; University of Helsinki; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Universitat Greifswald; Greifswald Medical School; University of Oxford; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; University of London; King's College London; University of Alabama System; University of Alabama Birmingham; Brown University; University System of Maryland; University of Maryland Baltimore; University of Hong Kong; Rush University; University of Pennsylvania; University of Southern Denmark; Naestved Hospital; University of Manchester; University of Tokyo; University of Osaka; Norwegian University of Science & Technology (NTNU); Harvard University; Harvard T.H. Chan School of Public Health; Universitat Greifswald; Greifswald Medical School; Geisinger Health System; National & Kapodistrian University of Athens; University System of Ohio; Ohio State University; Utah System of Higher Education; University of Utah; Brown University; Brown University; Aarhus University; Aarhus University; University of Bergen; University of Nebraska System; University of Nebraska Medical Center; University of Iceland; Uppsala University; University of Edinburgh; University System of Maryland; University of Maryland Baltimore; Yale University; Norwegian University of Science & Technology (NTNU); Juntendo University; Shimane University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; University of London; Queen Mary University London; Peking University; Peking University; QIMR Berghofer Medical Research Institute; Queensland University of Technology (QUT); QIMR Berghofer Medical Research Institute; Tufts Medical Center; University of Queensland; University of Queensland; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; Shimane University; University of Copenhagen; University of Hong Kong; University of Alabama System; University of Alabama Birmingham; Baylor College of Medicine; RIKEN; Juntendo University; Shizuoka General Hospital; University of Shizuoka; University of Copenhagen; University of Thessaly; Statens Serum Institut; University of Nottingham; University of Sheffield; University of Oslo; University of Oslo; University of Oslo; University of Cambridge; Technical University of Munich
摘要：Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes1. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide2. As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed. Here we perform a genome-wide association study meta-analyses across up to 489,975 cases and 1,472,094 controls, establishing 962 independent ...
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作者：Finkbeiner, Ann
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作者：Al Reza, Hasan; Santangelo, Connie; Iwasawa, Kentaro; Al Reza, Abid; Sekiya, Sachiko; Glaser, Kathryn; Bondoc, Alexander; Merola, Jonathan; Takebe, Takanori
作者单位：Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; University of Osaka; University of Osaka; Yokohama City University
摘要：Distinct hepatocyte subpopulations are spatially segregated along the portal-central axis and are critical to understanding metabolic homeostasis and injury in the liver1. Although several bioactive molecules, including ascorbate and bilirubin, have been described as having a role in directing zonal fates, zonal liver architecture has not yet been replicated in vitro2,3. Here, to evaluate hepatic zonal polarity, we developed a self-assembling zone-specific liver organoid by co-culturing ascorb...
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作者：Zhang, Chang; Xiang, Xiangying; Liu, Jian; Huang, Yongjie; Xue, Jingwen; Sun, Qian; Leng, Song; Liu, Shaobo; He, Xuefei; Hu, Peng; Zhan, Xiangjiang; Qiu, Qiang; Yang, Shilong; Brosius, Juergen; Deng, Cheng
作者单位：Sichuan University; Nanjing Normal University; Shanghai Ocean University; Chinese Academy of Sciences; Institute of Zoology, CAS; Chinese Academy of Sciences; Institute of Zoology, CAS; Northwestern Polytechnical University; Northeast Forestry University - China
摘要：The maintenance of blood glucose, the body's primary source of energy, is indispensable for overall health and metabolic homeostasis. It is regulated predominantly by the glucagon receptor family which is highly conserved in vertebrates1, 2, 3-4. Compared with other vertebrates, avian blood glucose levels are relatively high5,6, and blood glucose regulatory mechanisms in birds have remained unclear. Here we show that high hepatic expression of the avian glucagon receptor (GCGR) in association ...
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作者：Mitchinson, Andrew
摘要：An analysis of landscape features and of river deposits preserved in caves point to an event 2.1 million years ago that triggered the formation of Hells Canyon.
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作者：Donato, Flavio; Rompani, Santiago Belluco; Caroni, Pico
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作者：Varanese, Lauren; Xu, Lily; Peters, Christine E.; Pintilie, Grigore; Roberts, David S.; Raj, Suyash; Liu, Mengying; Ooi, Yaw Shin; Diep, Jonathan; Qiao, Wenjie; Richards, Christopher M.; Callaway, Jeremy; Bertozzi, Carolyn R.; Jabs, Sabrina; de Vries, Erik; van Kuppeveld, Frank J. M.; Nagamine, Claude M.; Chiu, Wah; Carette, Jan E.
作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Utrecht University; National University of Singapore; Howard Hughes Medical Institute; Stanford University; University of Kiel; Schleswig Holstein University Hospital; Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory
摘要：With the near eradication of poliovirus due to global vaccination campaigns, attention has shifted to other enteroviruses that can cause polio-like paralysis syndrome (now termed acute flaccid myelitis)1, 2-3. In particular, enterovirus D68 (EV-D68) is believed to be the main driver of epidemic outbreaks of acute flaccid myelitis in recent years4, yet not much is known about EV-D68 host interactions. EV-D68 is a respiratory virus5 but, in rare cases, can spread to the central nervous system to...
