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作者：Jones, Daniel O. B.; Arias, Maria Belen; Van Audenhaege, Loic; Blackbird, Sabena; Boolukos, Corie; Bribiesca-Contreras, Guadalupe; Copley, Jonathan T.; Dale, Andrew; Evans, Susan; Fleming, Bethany F. M.; Gates, Andrew R.; Grant, Hannah; Hartl, Mark G. J.; Huvenne, Veerle A. I.; Jeffreys, Rachel M.; Josso, Pierre; King, Lucas D.; Simon-Lledo, Erik; Le Bas, Tim; Norman, Louisa; O'Malley, Bryan; Peacock, Thomas; Shimmield, Tracy; Stewart, Eva C. D.; Sweetman, Andrew K.; Wardell, Catherine; Aleynik, Dmitry; Glover, Adrian G.
作者单位：University of Southampton; NERC National Oceanography Centre; Natural History Museum London; University of Liverpool; University of Southampton; University of the Highlands & Islands; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Geological Survey; Heriot Watt University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro Mediterraneo de Investigaciones Marinas y Ambientales (CMIMA); CSIC - Instituto de Ciencias del Mar (ICM); Massachusetts Institute of Technology (MIT)
摘要：Deep-sea polymetallic nodule mining is in the exploration phase at present with some groups proposing a move towards extraction within years1. Management of this industry requires evidence of the long-term effects on deep-sea ecosystems2, but the ability of seafloor ecosystems to recover from impacts over decadal scales is poorly understood3. Here we show that, four decades after a test mining experiment that removed nodules, the biological impacts in many groups of organisms are persistent, a...
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作者：Gueye, Gaoussou
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作者：Haridy, Yara; Norris, Sam C. P.; Fabbri, Matteo; Nanglu, Karma; Sharma, Neelima; Miller, James F.; Rivers, Mark; La Riviere, Patrick; Vargas, Phillip; Ortega-Hernandez, Javier; Shubin, Neil H.
作者单位：University of Chicago; Johns Hopkins University; Harvard University; University of Toronto; University of California System; University of California Riverside; Missouri State University; University of Chicago; University of Chicago
摘要：The earliest record of tooth antecedents and the tissue dentine1,2, an early-vertebrate novelty, has been controversially represented by fragmentary Cambrian fossils identified as Anatolepis heintzi3, 4-5. Anatolepis exoskeletons have the characteristic tubules of dentine that prompted their interpretation as the first precursors of teeth3, known as odontodes. Debates over whether Anatolepis is a legitimate vertebrate6, 7-8 have arisen because of limitations in imaging and the lack of comparat...
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作者：Jann, Johann-Christoph; Tothova, Zuzana
作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：The risk of developing blood cancer increases with age. The finding that a molecule from gut bacteria plays a part points to new ways to intervene.
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作者：Asrar, Farhan M.
作者单位：University of Toronto; Toronto Metropolitan University
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作者：Mota, Maria M.
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作者：Igarashi, Ryo; Oda, Mayumi; Okada, Ryo; Yano, Tomoki; Takahashi, Sirirat; Pastuhov, Strahil; Matano, Mami; Masuda, Norio; Togasaki, Kazuhiro; Ohta, Yuki; Sato, Saeko; Hishiki, Takako; Suematsu, Makoto; Itoh, Manabu; Fujii, Masayuki; Sato, Toshiro
作者单位：Keio University; Keio University; JSR Corporation; Keio University
摘要：Proliferating hepatocytes often undergo ductal metaplasia to balance the energy trade-off between cellular functions and replication, hindering the expansion of human adult hepatocytes with functional competency1. Here we demonstrate that the combined activation of Wnt and STAT3 signalling enables long-term self-renewal of human adult hepatocyte organoids. YAP activation facilitates hepatocyte proliferation but commits it towards the biliary duct lineage. By contrast, STAT3 activation by oncos...
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作者：Nern, Aljoscha; Loesche, Frank; Takemura, Shin-ya; Burnett, Laura E.; Dreher, Marisa; Gruntman, Eyal; Hoeller, Judith; Huang, Gary B.; Januszewski, Michal; Klapoetke, Nathan C.; Koskela, Sanna; Longden, Kit D.; Lu, Zhiyuan; Preibisch, Stephan; Qiu, Wei; Rogers, Edward M.; Seenivasan, Pavithraa; Zhao, Arthur; Bogovic, John; Canino, Brandon S.; Clements, Jody; Cook, Michael; Finley-May, Samantha; Flynn, Miriam A.; Hameed, Imran; Fragniere, Alexandra M. C.; Hayworth, Kenneth J.; Hopkins, Gary Patrick; Hubbard, Philip M.; Katz, William T.; Kovalyak, Julie; Lauchie, Shirley A.; Leonard, Meghan; Lohff, Alanna; Maldonado, Charli A.; Mooney, Caroline; Okeoma, Nneoma; Olbris, Donald J.; Ordish, Christopher; Paterson, Tyler; Phillips, Emily M.; Pietzsch, Tobias; Salinas, Jennifer Rivas; Rivlin, Patricia K.; Schlegel, Philipp; Scott, Ashley L.; Scuderi, Louis A.; Takemura, Satoko; Talebi, Iris; Thomson, Alexander; Trautman, Eric T.; Umayam, Lowell; Walsh, Claire; Walsh, John J.; Xu, C. Shan; Yakal, Emily A.; Yang, Tansy; Zhao, Ting; Funke, Jan; George, Reed; Hess, Harald F.; Jefferis, Gregory S. X. E.; Knecht, Christopher; Korff, Wyatt; Plaza, Stephen M.; Romani, Sandro; Saalfeld, Stephan; Scheffer, Louis K.; Berg, Stuart; Rubin, Gerald M.; Reiser, Michael B.
作者单位：Howard Hughes Medical Institute; University of Toronto; University Toronto Scarborough; Alphabet Inc.; Google Incorporated; MRC Laboratory Molecular Biology; University of Cambridge
摘要：Vision provides animals with detailed information about their surroundings and conveys diverse features such as colour, form and movement across the visual scene. Computing these parallel spatial features requires a large and diverse network of neurons. Consequently, from flies to humans, visual regions in the brain constitute half its volume. These visual regions often have marked structure-function relationships, with neurons organized along spatial maps and with shapes that directly relate ...
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作者：Machery, Edouard; Doris, John M.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Cornell University
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作者：Sumida, Stuart S.
作者单位：California State University System; California State University San Bernardino
