2025

最新文章

• Structural basis of lipid transfer by a bridge-like lipid-transfer protein AI翻译
  作者：Kang, Yunsik; Lehmann, Katherine S.; Long, Hannah; Jefferson, Amanda; Purice, Maria; Freeman, Marc; Clark, Sarah
  作者单位：Oregon Health & Science University; University of Colorado System; University of Colorado Anschutz Medical Campus; Oregon State University; Fred Hutchinson Cancer Center
  摘要：Bridge-like lipid-transport proteins (BLTPs) are an evolutionarily conserved family of proteins that localize to membrane-contact sites and are thought to mediate the bulk transfer of lipids from a donor membrane, typically the endoplasmic reticulum, to an acceptor membrane, such as that of the cell or an organelle1. Although BLTPs are fundamentally important for a wide array of cellular functions, their architecture, composition and lipid-transfer mechanisms remain poorly characterized. Here ...
• Gender equality in research publishing is a responsibility for everyone AI翻译
  作者：[Anonymous]
• Targeting the SHOC2-RAS interaction in RAS-mutant cancers AI翻译
  作者：Hauseman, Zachary J.; Stauffer, Frederic; Beyer, Kim S.; Molle, Sandra; Cavicchioli, Elena; Marchand, Jean-Remy; Fodor, Michelle; Viscomi, Jessica; Dhembi, Anxhela; Katz, Stephanie; Faggion, Beatrice; Lanter, Mylene; Kerr, Grainne; Schildknecht, Daniela; Handl, Cornelia; Maddalo, Danilo; Soldermann, Carole Pissot; Brady, Jacob; Shrestha, Om; Nguyen, Zachary; Leder, Lukas; Cremosnik, Gregor; Romero, Sandra Lopez; Hassiepen, Ulrich; Stams, Travis; Linder, Markus; Galli, Giorgio G.; Guthy, Daniel A.; King, Daniel A.; Maira, Sauveur-Michel; Thoma, Claudio R.; Ehmke, Veronika; Tordella, Luca
  作者单位：Novartis; Novartis USA; Novartis
  摘要：Activating mutations in the rat sarcoma (RAS) genes HRAS, NRAS and KRAS collectively represent the most frequent oncogenic driver in human cancer1. They have previously been considered undruggable, but advances in the past few years have led to the clinical development of agents that target KRAS(G12C) and KRAS(G12D) mutants, yielding promises of therapeutic responses at tolerated doses2. However, clinical agents that selectively target NRAS(Q61*) mutants (* represents 'any'), the second-most-f...
• Reply to: False positives in study of memory-related gene expression AI翻译
  作者：Sun, Wenfei; Liu, Zhihui; Jiang, Xian; Chen, Michelle B.; Dong, Hua; Liu, Jonathan; Sudhof, Thomas C.; Quake, Stephen R.
  作者单位：Stanford University; Stanford University; Howard Hughes Medical Institute; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI)
• Blocking a key node in cancer signalling unlocks therapeutic potential AI翻译
  作者：Lavoie, Hugo; Therrien, Marc
  作者单位：Universite de Montreal
• The 'pivot penalty': scientists get cited less after switching fields, analysis finds AI翻译
  作者：Lenharo, Mariana
• Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer AI翻译
  作者：Pei, Guangsheng; Min, Jimin; Rajapakshe, Kimal I.; Branchi, Vittorio; Liu, Yunhe; Selvanesan, Benson Chellakkan; Thege, Fredrik; Sadeghian, Dorsay; Zhang, Daiwei; Cho, Kyung Serk; Chu, Yanshuo; Dai, Enyu; Han, Guangchun; Li, Mingyao; Yee, Cassian; Takahashi, Kazuki; Garg, Bharti; Tiriac, Herve; Bernard, Vincent; Semaan, Alexander; Grem, Jean L.; Caffrey, Thomas C.; Burks, Jared K.; Lowy, Andrew M.; Aguirre, Andrew J.; Grandgenett, Paul M.; Hollingsworth, Michael A.; Guerrero, Paola A.; Wang, Linghua; Maitra, Anirban
  作者单位：University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Pennsylvania; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of California System; University of California San Diego; University of Texas System; UTMD Anderson Cancer Center; University of Bonn; University of Nebraska System; University of Nebraska Medical Center; University of Nebraska System; University of Nebraska Medical Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center
  摘要：Patients with treatment-refractory pancreatic cancer often succumb to systemic metastases1, 2-3; however, the transcriptomic heterogeneity that underlies therapeutic recalcitrance remains understudied, particularly in a spatial context. Here we construct high-resolution maps of lineage states, clonal architecture and the tumour microenvironment (TME) using spatially resolved transcriptomics from 55 samples of primary tumour and metastases (liver, lung and peritoneum) collected from rapid autop...
• Address the psychological toll of kidney disease AI翻译
  作者：Li, Rongkang; Peng, Lei; Zhang, Shaohua; Wu, Song
  作者单位：Shenzhen University
• False positives in study of memory-related gene expression AI翻译
  作者：Mukamel, Eran A.; Yu, Zhaoxia
  作者单位：University of California System; University of California San Diego; University of California System; University of California Irvine
• Underwater kelp forests are losing a turf war AI翻译
  作者：Smith, Holly
  摘要：In warming coastal seas, a crucial ecosystem is being replaced by 'turfs' of red algae, which release chemicals that suppress kelp survival.