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作者：[Anonymous]
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作者：Kiyuka, Patience
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作者：[Anonymous]
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作者：Listov, Dina; Vos, Eva; Hoffka, Gyula; Hoch, Shlomo Yakir; Berg, Andrej; Hamer-Rogotner, Shelly; Dym, Orly; Kamerlin, Shina Caroline Lynn; Fleishman, Sarel J.
作者单位：Weizmann Institute of Science; University System of Georgia; Georgia Institute of Technology; Lund University; University of Debrecen; Uppsala University; Weizmann Institute of Science
摘要：Until now, computationally designed enzymes exhibited low catalytic rates1, 2, 3, 4-5 and required intensive experimental optimization to reach activity levels observed in comparable natural enzymes5, 6, 7, 8-9. These results exposed limitations in design methodology and suggested critical gaps in our understanding of the fundamentals of biocatalysis10,11. We present a fully computational workflow for designing efficient enzymes in TIM-barrel folds using backbone fragments from natural protein...
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作者：Migliavacca, Mirco; Grassi, Giacomo; Bastos, Ana; Ceccherini, Guido; Ciais, Philippe; Janssens-Maenhout, Greet; Lugato, Emanuele; Mahecha, Miguel D.; Novick, Kimberly A.; Penuelas, Josep; Pilli, Roberto; Reichstein, Markus; Avitabile, Valerio; Beck, Pieter S. A.; Barredo, Jose I.; Forzieri, Giovanni; Herold, Martin; Korosuo, Anu; Mansuy, Nicolas; Mubareka, Sarah; Orth, Rene; Rougieux, Paul; Cescatti, Alessandro
作者单位：European Commission Joint Research Centre; EC JRC ISPRA Site; Leipzig University; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); European Commission Joint Research Centre; EC JRC ISPRA Site; Universite Paris Saclay; CEA; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); Indiana University System; Indiana University Bloomington; Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); University of Barcelona; Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); Consejo Superior de Investigaciones Cientificas (CSIC); Max Planck Society; University of Florence; University of Potsdam; Natural Resources Canada; Canadian Forest Service; University of Freiburg
摘要：The European Union (EU) climate policies rely on a functioning forest carbon sink. Forests cover about 40% of the EU area and have absorbed about 436 Mt of carbon dioxide equivalent per year between 1990 and 2022, which is about 10% of the EU's anthropogenic emissions. However, the ability of forests to act as carbon sinks is rapidly declining owing to increasing natural and anthropogenic pressures, threatening the EU's climate goals and calling for prompt actions. Here we provide actionable r...
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作者：Gibney, Elizabeth
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作者：Witt, Kristen C.; Dziulko, Adam; An, Joohyun; Pekovic, Filip; Cheng, Arthur Xiuyuan; Liu, Grace Y.; Lee, Ophelia Vosshall; Turner, David J.; Lari, Azra; Gaidt, Moritz M.; Chavez, Roberto; Fattinger, Stefan A.; Abraham, Preethy; Dhaliwal, Harmandeep; Lee, Angus Y.; Kotov, Dmitri I.; Coscoy, Laurent; Glaunsinger, Britt A.; Valkov, Eugene; Chuong, Edward B.; Vance, Russell E.
作者单位：University of California System; University of California Berkeley; Howard Hughes Medical Institute; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); University of California System; University of California Berkeley; University of California System; University of California Berkeley; Vienna Biocenter (VBC); Research Institute of Molecular Pathology (IMP)
摘要：Type I interferons are essential for antiviral immunity1 but must be tightly regulated2. The conserved transcriptional repressor SP140 inhibits interferon-beta (Ifnb1) expression through an unknown mechanism3,4. Here we report that SP140 does not directly repress Ifnb1 transcription. Instead, SP140 negatively regulates Ifnb1 mRNA stability by directly repressing the expression of a previously uncharacterized regulator that we call RESIST (regulated stimulator of interferon via stabilization of...
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作者：Nordling, Linda
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作者：Sahin, Ugur; Muik, Alexander; Vogler, Isabel; Derhovanessian, Evelyna; Kranz, Lena M.; Vormehr, Mathias; Quandt, Jasmin; Bidmon, Nicole; Ulges, Alexander; Baum, Alina; Pascal, Kristen E.; Maurus, Daniel; Brachtendorf, Sebastian; Loerks, Verena; Sikorski, Julian; Koch, Peter; Hilker, Rolf; Becker, Dirk; Eller, Ann-Kathrin; Gruetzner, Jan; Tonigold, Manuel; Boesler, Carsten; Rosenbaum, Corinna; Heesen, Ludwig; Kuehnle, Marie-Cristine; Poran, Asaf; Dong, Jesse Z.; Luxemburger, Ulrich; Kemmer-Brueck, Alexandra; Langer, David; Bexon, Martin; Bolte, Stefanie; Palanche, Tania; Schultz, Armin; Baumann, Sybille; Mahiny, Azita J.; Boros, Gabor; Reinholz, Jonas; Szabo, Gabor T.; Kariko, Katalin; Shi, Pei-Yong; Fontes-Garfias, Camila; Perez, John L.; Cutler, Mark; Cooper, David; Kyratsous, Christos A.; Dormitzer, Philip R.; Jansen, Kathrin U.; Tuereci, Oezlem
作者单位：BioNTech SE; Johannes Gutenberg University of Mainz; Regeneron; BioNTech SE; University of Texas System; University of Texas Medical Branch Galveston; Pfizer; Pfizer USA
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作者：Ackermann, N.; Bonet, H.; Bonhomme, A.; Buck, C.; Fuelber, K.; Hakenmueller, J.; Hempfling, J.; Heusser, G.; Lindner, M.; Maneschg, W.; Ni, K.; Rank, M.; Rink, T.; Sanchez Garcia, E.; Stalder, I.; Strecker, H.; Wink, R.; Woenckhaus, J.
作者单位：Max Planck Society; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); Duke University; Helmholtz Association; Karlsruhe Institute of Technology; Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute
摘要：Neutrinos are elementary particles that interact only very weakly with matter. Neutrino experiments are, therefore, usually big, with masses in the multi-tonne range. The thresholdless interaction of coherent elastic scattering of neutrinos on atomic nuclei leads to greatly enhanced interaction rates, which allows for much smaller detectors. The study of this process gives insights into physics beyond the Standard Model of particle physics. The CONUS+ experiment1 was designed to first detect e...
