Diverse bat organoids provide pathophysiological models for zoonotic viruses

• 成果类型: Article
• 署名作者: Kim, Hyunjoon; Heo, Seo-Young; Kim, Young-Il; Park, Dongbin; Hwang, Suhee; Lee, Yong-ki; Jang, Hobin; Ahn, Jae-Woo; Ha, Jeongmin; Park, Sujin; Ji, Ho Young; Kim, Semi; Choi, Isaac; Kwon, Woohyun; Kim, Jaemoo; Kim, Kanghee; Gil, Juryeon; Jeong, Boyeong; Lazarte, Josea Carmel D.; Rollon, Rare; Choi, Jeong Ho; Kim, Eun Ha; Jang, Seung-Gyu; Kim, Hye Kwon; Jeon, Bo-Young; Kayali, Ghazi; Webby, Richard J.; Koo, Bon-Kyoung; Choi, Young Ki
• 署名单位: Institute for Basic Science - Korea (IBS); Sungkyunkwan University (SKKU); Institute for Basic Science - Korea (IBS); Chungbuk National University; Chungbuk National University; Chungbuk National University; Yonsei University; St Jude Children's Research Hospital; Korea Advanced Institute of Science & Technology (KAIST); Pohang University of Science & Technology (POSTECH)
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-10109
• DOI: 10.1126/science.adt1438
• 发表日期: 2025-05-15
• 页码: 756-762
• 关键词: rna; cells; TREE

摘要

Bats are important reservoirs of zoonotic pathogens, but suitable model systems for comprehensively exploring host-pathogen interactions and assessing spillover risks remain limited. To address this gap, we developed a collection of bat organoid models spanning five species and four organ types. This multispecies, multiorgan organoid panel showed species- and tissue-specific replication patterns for several viruses, offering robust pathophysiological models for studying respiratory, renal, and enteric zoonotic viruses. Using this platform, we successfully isolated and characterized bat-borne mammalian orthoreoviruses and paramyxoviruses, demonstrating the utility of these organoid panels for virome surveillance. Furthermore, we successfully tested known antiviral drugs for their efficacy against bat virus isolates.