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作者：Wang, Joy Y.; Doudna, Jennifer A.
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Howard Hughes Medical Institute; University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California San Francisco; The J David Gladstone Institutes
摘要：The advent of clustered regularly interspaced short palindromic repeat (CRISPR) genome editing, coupled with advances in computing and imaging capabilities, has initiated a new era in which genetic diseases and individual disease susceptibilities are both predictable and actionable. Likewise, genes responsible for plant traits can be identified and altered quickly, transforming the pace of agricultural research and plant breeding. In this Review, we discuss the current state of CRISPR-mediated...
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作者：Warner, Koko; Weisberg, Michael
作者单位：University of Pennsylvania; International Organization for Migration; University of Pennsylvania; University of Pennsylvania
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作者：[Anonymous]
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作者：[Anonymous]
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作者：Petitdemange, Ludovic; Marcotte, Florence; Gissinger, Christophe
作者单位：Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite PSL; Observatoire de Paris; Centre National de la Recherche Scientifique (CNRS); Universite Cote d'Azur; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Normale Superieure (ENS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Paris Cite; Institut Universitaire de France
摘要：The evolution of a star is influenced by its internal rotation dynamics through transport and mixing mechanisms, which are poorly understood. Magnetic fields can play a role in transporting angular momentum and chemical elements, but the origin of magnetism in radiative stellar layers is unclear. Using global numerical simulations, we identify a subcritical transition from laminar flow to turbulence caused by the generation of a magnetic dynamo. Our results have many properties of the theoreti...
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作者：Mlynarczyk, Coraline; Teater, Matt; Pae, Juhee; Chin, Christopher R.; Wang, Ling; Arulraj, Theinmozhi; Barisic, Darko; Papin, Antonin; Hoehn, Kenneth B.; Kots, Ekaterina; Ersching, Jonatan; Bandyopadhyay, Arnab; Barin, Ersilia; Poh, Hui Xian; Evans, Chiara M.; Chadburn, Amy; Chen, Zhengming; Shen, Hao; Isles, Hannah M.; Pelzer, Benedikt; Tsialta, Ioanna; Doane, Ashley S.; Geng, Huimin; Rehman, Muhammad Hassan; Melnick, Jonah; Morgan, Wyatt; Nguyen, Diu T. T.; Elemento, Olivier; Kharas, Michael G.; Jaffrey, Samie R.; Scott, David W.; Khelashvili, George; Meyer-Hermann, Michael; Victora, Gabriel D.; Melnick, Ari
作者单位：Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Rockefeller University; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Helmholtz Association; Helmholtz-Center for Infection Research; Helmholtz Association; Helmholtz-Center for Infection Research; Cornell University; Weill Cornell Medicine; Yale University; Cornell University; Weill Cornell Medicine; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; University of California System; University of California San Francisco; Qatar Foundation (QF); Weill Cornell Medical College Qatar; University of London; Queen Mary University London; Cornell University; Weill Cornell Medicine; British Columbia Cancer Agency; Braunschweig University of Technology
摘要：Multicellular life requires altruistic cooperation between cells. The adaptive immune system is a notable exception, wherein germinal center B cells compete vigorously for limiting positive selection signals. Studying primary human lymphomas and developing new mouse models, we found that mutations affecting BTG1 disrupt a critical immune gatekeeper mechanism that strictly limits B cell fitness during antibody affinity maturation. This mechanism converted germinal center B cells into supercompe...
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作者：Offord, Catherine
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作者：O'Grady, Cathleen
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作者：You, Shuai; Zeng, Haipeng; Liu, Yuhang; Han, Bing; Li, Min; Li, Lin; Zheng, Xin; Guo, Rui; Luo, Long; Li, Zhe; Zhang, Chi; Liu, Ranran; Zhao, Yang; Zhang, Shujing; Peng, Qi; Wang, Ti; Chen, Qi; Eickemeyer, Felix T.; Carlsen, Brian; Zakeeruddin, Shaik M.; Mai, Liqiang; Rong, Yaoguang; Gratzel, Michael; Li, Xiong
作者单位：Huazhong University of Science & Technology; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Southern University of Science & Technology; Wuhan University; Wuhan University; Chinese Academy of Sciences; Suzhou Institute of Nano-Tech & Nano-Bionics, CAS; Wuhan University of Technology
摘要：High-quality perovskite light harvesters and robust organic hole extraction layers are essential for achieving high-performing perovskite solar cells (PSCs). We introduce a phosphonic acid???functionalized fullerene derivative in mixed-cation perovskites as a grain boundary modulator to consolidate the crystal structure, which enhances the tolerance of the film against illumination, heat, and moisture. We also developed a redox-active radical polymer, poly(oxoammonium salt), that can effective...
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作者：Mandelker, Diana; Ladanyi, Marc
作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center
