作者：Powell, Luke L.; Capela, Joana; Guedes, Patricia; Beja, Pedro
作者单位：Universidade do Porto; Universidade do Porto; University of Glasgow; Universidade de Lisboa
作者：Kagan, Jonathan C.
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital
作者：Pena, Ricardo De La; Hodgson, Hannah; Liu, Jack Chun -Ting; Stephenson, Michael J.; Martin, Azahara C.; Owen, Charlotte; Harkess, Alex; Leebens-Mack, Jim; Jimenez, Luis E.; Osbourn, Anne; Sattely, Elizabeth S.
作者单位：Stanford University; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; Stanford University; University of East Anglia; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; HudsonAlpha Institute for Biotechnology; University System of Georgia; University of Georgia; Howard Hughes Medical Institute; Stanford University
摘要：Triterpenes with complex scaffold modifications are widespread in the plant kingdom. Limonoids are an exemplary family that are responsible for the bitter taste in citrus (e.g., limonin) and the active constituents of neem oil, a widely used bioinsecticide (e.g., azadirachtin). Despite the commercial value of limonoids, a complete biosynthetic route has not been described. We report the discovery of 22 enzymes, including a pair of neofunctionalized sterol isomerases, that catalyze 12 distinct ...
作者：Lapola, David M.; Pinho, Patricia; Barlow, Jos; Aragao, Luiz E. O. C.; Berenguer, Erika; Carmenta, Rachel; Liddy, Hannah M.; Seixas, Hugo; Silva, Camila V. J.; Silva-Junior, Celso H. L.; Alencar, Ane A. C.; Anderson, Liana O.; Armenteras, Dolors; Brovkin, Victor; Calders, Kim; Chambers, Jeffrey; Chini, Louise; Costa, Marcos H.; Faria, Bruno L.; Fearnside, Philip M.; Ferreira, Joice; Gatti, Luciana; Gutierrez-Velez, Victor Hugo; Han, Zhangang; Hibbard, Kathleen; Koven, Charles; Lawrence, Peter; Pongratz, Julia; Portela, Bruno T. T.; Rounsevell, Mark; Ruane, Alex C.; Schaldach, Rudiger; da Silva, Sonaira S.; von Randow, Celso; Walker, Wayne S.
作者单位：Universidade Estadual de Campinas; Lancaster University; Instituto Nacional de Pesquisas Espaciais (INPE); University of Exeter; University of Oxford; University of East Anglia; Columbia University; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Goddard Institute for Space Studies; University of California System; University of California Los Angeles; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); Universidade Federal do Maranhao; Universidad Nacional de Colombia; Max Planck Society; Ghent University; University of Eastern Finland; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University System of Maryland; University of Maryland College Park; Universidade Federal de Vicosa; Instituto Federal do Norte de Minas Gerais (IFNMG); Institute Nacional de Pesquisas da Amazonia; Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA); Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; Beijing Normal University; National Aeronautics & Space Administration (NASA); National Center Atmospheric Research (NCAR) - USA; University of Munich; Helmholtz Association; Karlsruhe Institute of Technology; University of Edinburgh; Universitat Kassel
作者：Dawkins, Marian Stamp
作者单位：University of Oxford
