Science

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• A trade-off between investment in molecular defense repertoires and growth in plants AI翻译
  作者：Giolai, Michael; Laine, Anna-Liisa
  作者单位：University of Helsinki
  摘要：Given the negative fitness effects that pathogens impose on their hosts, the benefits of resistance should be universal. However, there is marked variation across plant species in the number of nucleotide-binding leucine-rich repeat receptors, which form a cornerstone of defense. The growth-defense trade-off hypothesis predicts costs associated with defense investment to generate variation in these traits. Our analysis comparing features of the intracellular immune-receptor repertoires with tr...
• Eyes are windows to the brain: Capturing eye movements to better understand face processing in autism AI翻译
  作者：Griffin, Jason
  作者单位：University of Houston System; University of Houston
• Analysis methods for large-scale neuronal recordings AI翻译
  作者：Stringer, Carsen; Pachitariu, Marius
  摘要：Simultaneous recordings from hundreds or thousands of neurons are becoming routine because of innovations in instrumentation, molecular tools, and data processing software. Such recordings can be analyzed with data science methods, but it is not immediately clear what methods to use or how to adapt them for neuroscience applications. We review, categorize, and illustrate diverse analysis methods for neural population recordings and describe how these methods have been used to make progress on ...
• Blue: A History of Postpartum Depression in America AI翻译
  作者：Somerstein, Rachel
  作者单位：State University of New York (SUNY) System; SUNY New Paltz
• Exploring structural diversity across the protein universe with The Encyclopedia of Domains AI翻译
  作者：Lau, Andy M.; Bordin, Nicola; Kandathil, Shaun M.; Sillitoe, Ian; Waman, Vaishali P.; Wells, Jude; Orengo, Christine A.; Jones, David T.
  作者单位：University of London; University College London; University of London; University College London; Birkbeck University London; University of London; University College London
  摘要：The AlphaFold Protein Structure Database (AFDB) contains more than 214 million predicted protein structures composed of domains, which are independently folding units found in multiple structural and functional contexts. Identifying domains can enable many functional and evolutionary analyses but has remained challenging because of the sheer scale of the data. Using deep learning methods, we have detected and classified every domain in the AFDB, producing The Encyclopedia of Domains. We detect...
• Passive materials-based solutions for cool and radiant cities AI翻译
  作者：Yin, Xiaobo
• Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior AI翻译
  作者：Barron, Jerika J.; Mroz, Nicholas M.; Taloma, Sunrae E.; Dahlgren, Madelene W.; Ortiz-Carpena, Jorge F.; Keefe, Matthew G.; Escoubas, Caroline C.; Dorman, Leah C.; Vainchtein, Ilia D.; Chiaranunt, Pailin; Kotas, Maya E.; Nowakowski, Tomasz J.; Bender, Kevin J.; Molofsky, Ari B.; Molofsky, Anna V.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Lund University; University of California System; University of California San Francisco; Chan Zuckerberg Initiative (CZI); University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：The innate immune system shapes brain development and is implicated in neurodevelopmental diseases. It is critical to define the relevant immune cells and signals and their impact on brain circuits. In this work, we found that group 2 innate lymphoid cells (ILC2s) and their cytokine interleukin-13 (IL-13) signaled directly to inhibitory interneurons to increase inhibitory synapse density in the developing mouse brain. ILC2s expanded and produced IL-13 in the developing brain meninges. Loss of ...
• First responders have it covered AI翻译
  作者：Green, Miranda; Foster, Jane A.
  作者单位：McMaster University; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
• A FIELD'S DILEMMAS FEATURESMisinformation research has exploded. But scientists are still grappling with fundamental challenges AI翻译
  作者：Kupferschmidt, Kai
• Cornerstone medical ethics guidelines get a major update AI翻译
  作者：O'Grady, Cathleen