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作者：Voosen, Paul
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作者：Wadman, Meredith
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作者：Hines, Sophia K. V.; Charles, Christopher D.; Starr, Aidan; Goldstein, Steven L.; Hemming, Sidney R.; Hall, Ian R.; Lathika, Nambiyathodi; Passacantando, Mollie; Bolge, Louise
作者单位：Woods Hole Oceanographic Institution; University of California System; University of California San Diego; Scripps Institution of Oceanography; Rutgers University System; Rutgers University New Brunswick; University of Cambridge; Columbia University; Columbia University; Cardiff University; Ministry of Earth Sciences (MoES) - India; National Centre for Polar and Ocean Research (NCPOR); University of Rhode Island
摘要：The mid-Pleistocene transition (MPT) [similar to 1.25 to 0.85 million years ago (Ma)] marks a shift in the character of glacial-interglacial climate (1, 2). One prevailing hypothesis for the origin of the MPT is that glacial deep ocean circulation fundamentally changed, marked by a circulation crisis at similar to 0.90 Ma (marine isotope stages 24 to 22) (3). Using high-resolution paired neodymium, carbon, and oxygen isotope data from the South Atlantic Ocean (Cape Basin) across the MPT, we fi...
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作者：Mann, Adam
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作者：Schipper, E. L. F.; Mukherji, A.
作者单位：University of Bonn; CGIAR
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作者：Brainard, Jeffrey
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作者：Chen, Zhiyuan; Tsui, Joseph L. -H.; Gutierrez, Bernardo; Busch Moreno, Simon; du Plessis, Louis; Deng, Xiaowei; Cai, Jun; Bajaj, Sumali; Suchard, Marc A.; Pybus, Oliver G.; Lemey, Philippe; Kraemer, Moritz U. G.; Yu, Hongjie
作者单位：Fudan University; University of Oxford; Universidad San Francisco de Quito; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Institute of Bioinformatics; Nanjing Medical University; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of London; University of London Royal Veterinary College; University of Oxford; KU Leuven; Fudan University; Fudan University
摘要：The global dynamics of seasonal influenza viruses inform the design of surveillance, intervention, and vaccination strategies. The COVID-19 pandemic provided a singular opportunity to evaluate how influenza circulation worldwide was perturbed by human behavioral changes. We combine molecular, epidemiological, and international travel data and find that the pandemic's onset led to a shift in the intensity and structure of international influenza lineage movement. During the pandemic, South Asia...
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作者：Greer, Kisha
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作者：Brainard, Jeffrey
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作者：Rix, Gordon; Williams, Rory L.; Hu, Vincent J.; Spinner, Aviv; Pisera, Alexander (Olek); Marks, Debora S.; Liu, Chang C.
作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of California System; University of California Irvine; University of California System; University of California Irvine
摘要：When nature evolves a gene over eons at scale, it produces a diversity of homologous sequences with patterns of conservation and change that contain rich structural, functional, and historical information about the gene. However, natural gene diversity accumulates slowly and likely excludes large regions of functional sequence space, limiting the information that is encoded and extractable. We introduce upgraded orthogonal DNA replication (OrthoRep) systems that radically accelerate the evolut...
