Analysis methods for large-scale neuronal recordings

• 成果类型: Review
• 署名作者: Stringer, Carsen; Pachitariu, Marius
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-13816
• DOI: 10.1126/science.adp7429
• 发表日期: 2024-11-08
• 关键词: population-dynamics; pattern generation; BEHAVIOR; orientation; modulation; circuits; ELEMENTS; cortex; memory; input

摘要

Simultaneous recordings from hundreds or thousands of neurons are becoming routine because of innovations in instrumentation, molecular tools, and data processing software. Such recordings can be analyzed with data science methods, but it is not immediately clear what methods to use or how to adapt them for neuroscience applications. We review, categorize, and illustrate diverse analysis methods for neural population recordings and describe how these methods have been used to make progress on longstanding questions in neuroscience. We review a variety of approaches, ranging from the mathematically simple to the complex, from exploratory to hypothesis-driven, and from recently developed to more established methods. We also illustrate some of the common statistical pitfalls in analyzing large-scale neural data.