Science

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• Collateral effects of pandemic control AI翻译
  作者：Rohani, Pejman; Bahl, Justin
  作者单位：University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia
• Global influenza threatens conservation AI翻译
  作者：Runstadler, Jonathan
  作者单位：Tufts University
• Ultrahigh-surface area covalent organic frameworks for methane adsorption AI翻译
  作者：Yin, Ying; Zhang, Ya; Zhou, Xu; Gui, Bo; Wang, Wenqi; Jiang, Wentao; Zhang, Yue-Biao; Sun, Junliang; Wang, Cheng
  作者单位：Wuhan University; Chinese Academy of Sciences; Peking University; ShanghaiTech University
  摘要：Developing porous materials with ultrahigh surface areas for gas storage (for example, methane) is attractive but challenging. Here, we report two isostructural three-dimensional covalent organic frameworks (COFs) with a rare self-catenated alb-3,6-Ccc2 topology and a pore size of 1.1 nanometer. Notably, these imine-linked microporous COFs show both high gravimetric Brunauer-Emmett-Teller (BET) surface areas (similar to 4400 square meters per gram) and volumetric BET surface areas (similar to ...
• Protect China's coastal salt marshes AI翻译
  作者：Feng, Xinhui; Li, Yan; Lin, Xinle
  作者单位：Zhejiang University
• Total synthesis of (-)-cylindrocyclophane A facilitated by C-H functionalization AI翻译
  作者：Bosse, Aaron T.; Hunt, Liam R.; Suarez, Camila A.; Casselman, Tyler D.; Goldstein, Elizabeth L.; Wright, Austin C.; Park, Hojoon; Virgil, Scott C.; Yu, Jin-Quan; Stoltz, Brian M.; Davies, Huw M. L.
  作者单位：Emory University; California Institute of Technology; Scripps Research Institute
  摘要：(-)-Cylindrocyclophane A is a 22-membered C2-symmetric [7.7]paracyclophane that bears bis-resorcinol functionality and six stereocenters. We report a synthetic strategy for (-)-cylindrocyclophane A that uses 10 C-H functionalization reactions, resulting in a streamlined route with high enantioselectivity and efficiency (17 steps). The use of chiral dirhodium tetracarboxylate catalysis enabled the C-H functionalization of primary and secondary positions, which was complemented by palladium-cata...
• The Forbidden Garden: The Botaninsts of Besieged Leningrand and Their Impossible Choice AI翻译
  作者：Haswell, Elizabeth
• Regulated N-glycosylation controls chaperone function and receptor trafficking AI翻译
  作者：Ma, Mengxiao; Dubey, Ramin; Jen, Annie; Pusapati, Ganesh V.; Singal, Bharti; Shishkova, Evgenia; Overmyer, Katherine A.; Cormier-Daire, Valerie; Fedry, Juliette; Aravind, L.; Coon, Joshua J.; Rohatgi, Rajat
  作者单位：Stanford University; Stanford University; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; The Morgridge Institute for Research, Inc.; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Necker-Enfants Malades - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); MRC Laboratory Molecular Biology; National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM); Division of Intramural Research (DIR); University of Wisconsin System; University of Wisconsin Madison
  摘要：One-fifth of human proteins are N-glycosylated in the endoplasmic reticulum (ER) by two oligosaccharyltransferases, OST-A and OST-B. Contrary to the prevailing view of N-glycosylation as a housekeeping function, we identified an ER pathway that modulates the activity of OST-A. Genetic analyses linked OST-A to HSP90B1, an ER chaperone for membrane receptors, and CCDC134, an ER luminal protein. During its translocation into the ER, an N-terminal peptide in HSP90B1 templates the assembly of a tra...
• C-LTMRs evoke wet dog shakes via the spinoparabrachial pathway AI翻译
  作者：Zhang, Dawei; Turecek, Josef; Choi, Seungwon; Delisle, Michelle; Pamplona, Caroline Leal; Meltzer, Shan; Ginty, David D.
  作者单位：Harvard University; Harvard Medical School; Howard Hughes Medical Institute; University of Texas System; University of Texas Southwestern Medical Center
  摘要：Many hairy mammals perform rapid oscillations of their body, called wet dog shakes, to remove water and irritants from their back hairy skin. The somatosensory mechanisms that underlie this behavior are unclear. We report that Piezo2-dependent mechanosensation mediates wet dog shakes evoked by water or oil droplets applied to back hairy skin of mice. Unmyelinated C-fiber low-threshold mechanoreceptors (C-LTMRs) were activated by oil droplets, and their optogenetic activation elicited wet dog s...
• Biodiversity meeting fumbles funding AI翻译
  作者：Brainard, Jeffrey
• India looks to ancient DNA to track migrations AI翻译
  作者：Chandrashekhar, Vaishnavi