COVID-19 pandemic interventions reshaped the global dispersal of seasonal influenza viruses

• 成果类型: Article
• 署名作者: Chen, Zhiyuan; Tsui, Joseph L. -H.; Gutierrez, Bernardo; Busch Moreno, Simon; du Plessis, Louis; Deng, Xiaowei; Cai, Jun; Bajaj, Sumali; Suchard, Marc A.; Pybus, Oliver G.; Lemey, Philippe; Kraemer, Moritz U. G.; Yu, Hongjie
• 署名单位: Fudan University; University of Oxford; Universidad San Francisco de Quito; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Institute of Bioinformatics; Nanjing Medical University; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of London; University of London Royal Veterinary College; University of Oxford; KU Leuven; Fudan University; Fudan University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-10148
• DOI: 10.1126/science.adq3003
• 发表日期: 2024-11-08
• 关键词: circulation patterns; a h3n2; DYNAMICS; MODEL; coalescent; epidemics; coverage; disease; HEALTH

摘要

The global dynamics of seasonal influenza viruses inform the design of surveillance, intervention, and vaccination strategies. The COVID-19 pandemic provided a singular opportunity to evaluate how influenza circulation worldwide was perturbed by human behavioral changes. We combine molecular, epidemiological, and international travel data and find that the pandemic's onset led to a shift in the intensity and structure of international influenza lineage movement. During the pandemic, South Asia played an important role as a phylogenetic trunk location of influenza A viruses, whereas West Asia maintained the circulation of influenza B/Victoria. We explore drivers of influenza lineage dynamics across the pandemic period and reasons for the possible extinction of the B/Yamagata lineage. After a period of 3 years, the intensity of among-region influenza lineage movements returned to pre-pandemic levels, with the exception of B/Yamagata, after the recovery of global air traffic, highlighting the robustness of global lineage dispersal patterns to substantial perturbation.