Proceedings of the National Academy of Sciences of the United States of America

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• Gene length could be a critical factor in the aging of the genome AI翻译
  作者：Brouillette, Monique
• Single-molecule force spectroscopy reveals intra- and intermolecular interactions of Caenorhabditis elegans HMP-1 during mechanotransduction AI翻译
  作者：Le, Shimin; Yu, Miao; Fu, Chaoyu; Heier, Jonathon A.; Martin, Sterling; Hardin, Jeff; Yan, Jie
  作者单位：National University of Singapore; Xiamen University; Zhejiang University; Zhejiang University; National University of Singapore; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; National University of Singapore; TJU-NUS Joint Institute
  摘要：The Caenorhabditis elegans HMP-2/HMP-1 complex, akin to the mammalian /3-catenin- a-catenin complex, serves as a critical mechanosensor at cell-cell adherens junctions, transducing tension between HMR-1 (also known as cadherin in mammals) and the actin cytoskeleton. Essential for embryonic development and tissue integrity in C. elegans, this complex experiences tension from both internal actomyosin contractility and external mechanical microenvironmental perturbations. While offering a valuabl...
• Relative genotoxicity of polycyclic aromatic hydrocarbons inferred from free energy perturbation approaches AI翻译
  作者：Urwin, Derek J.; Tran, Elise; Alexandrova, Anastassia N.
  作者单位：University of California System; University of California Los Angeles
  摘要：Utilizing molecular dynamics and free energy perturbation, we examine the relative binding affinity of several covalent polycyclic aromatic hydrocarbon- DNA (PAHDNA) adducts at the central adenine of NRAS codon-61, a mutational hotspot implicated in cancer risk. Several PAHs classified by the International Agency for Research on Cancer as probable, possible, or unclassifiable as to carcinogenicity are found to have greater binding affinity than the known carcinogen, benzo[a]pyrene (B[a]P). van...
• Shazam for birds AI翻译
  作者：Freeman, Benjamin G.
  作者单位：University System of Georgia; Georgia Institute of Technology
• Transport coefficient approach for characterizing nonequilibrium dynamics in soft matter (vol 30, e2401162121, 2024) AI翻译
  作者：He, HongRui; Liang, Heyi; Chu, Miaoqi; Jiang, Zhang; de Pablo, Juan J.; Tirrell, Matthew V.; Narayanan, Suresh; Chen, Wei
• Parallel ecological and evolutionary responses to selection in a natural bacterial community AI翻译
  作者：Hesse, Elze; Lujan, Adela M.; O'Brien, Siobhan; Newbury, Arthur; McAvoy, Terence; Pascual, Jesica Soria; Bayer, Florian; Hodgson, David J.; Buckling, Angus
  作者单位：University of Exeter; University of Exeter; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Catholic University of Cordoba; Catholic University of Cordoba; Trinity College Dublin
  摘要：Evolution can occur over ecological timescales, suggesting a potentially important role for rapid evolution in shaping community trait distributions. However, evidence of concordant eco- evolutionary dynamics often comes from in vitro studies of highly simplified communities, and measures of ecological and evolutionary dynamics are rarely directly comparable. Here, we quantified how ecological species sorting and rapid evolution simultaneously shape community trait distributions by tracking wi...
• Lysis of human erythrocytes due to Piezo1-dependent cytosolic calcium overload as a mechanism of circulatory removal AI翻译
  作者：Kuck, Lennart; McNamee, Antony P.; Bordukova, Maria; Sadafi, Ario; Marr, Carsten; Peart, Jason N.; Simmonds, Michael J.
  作者单位：Griffith University; Griffith University - Gold Coast Campus; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; University of Munich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Technical University of Munich; Griffith University; Griffith University - Gold Coast Campus
  摘要：Hematopoietic stem cells surrender organelles during differentiation, leaving mature red blood cells (RBC) devoid of transcriptional machinery and mitochondria. The resultant absence of cellular repair capacity limits RBC circulatory longevity, and old cells are removed from circulation. The specific age- dependent alterations required for this apparently targeted removal of RBC, however, remain elusive. Here, we assessed the function of Piezo1, a stretch- activated transmembrane cation channe...
• The role of funding in the performance of Latin America's protected areas AI翻译
  作者：Lessmann, Janeth; Geldmann, Jonas; Fajardo, Javier; Marquet, Pablo A.
  作者单位：Pontificia Universidad Catolica de Chile; Universidad de Chile; University of Copenhagen; University of Cambridge; The Santa Fe Institute; Pontificia Universidad Catolica de Chile
  摘要：Conservationists have long argued that inadequate funding for managing protected areas (PAs) jeopardizes their ability to achieve conservation goals. However, this claim has rarely been substantiated by quantitative evaluations. To address this, we examined the impact of funding on PA effectiveness both at the scale of 17 national PA systems across Latin America and within a PA system (Ecuador), for which we had precise historical financial data. Most PAs reduced deforestation between 2000 and...
• An intronic polymorphism associated with 2,3-bisphosphoglycerate levels in human red cells is linked to expression of RhCE blood groups AI翻译
  作者：McGowan, Eunike C.; Storry, Jill R.; Olsson, Martin L.
  作者单位：Lund University
• microRNA maintains nutrient homeostasis in the symbiont-host interaction AI翻译
  作者：Shang, Feng; Ding, Bi-Yue; Niu, Jinzhi; Lu, Jin-Ming; Xie, Xiu-Cheng; Li, Chuan-Zhen; Zhang, Wei; Pan, Deng; Jiang, Rui-Xu; Wang, Jin-Jun
  作者单位：Southwest University - China; Southwest University - China
  摘要：Endosymbionts provide essential nutrients for hosts, promoting growth, development, and reproduction. However, the molecular regulation of nutrient transport from endosymbiont to host is not well understood. Here, we used bioinformatic analysis, RNA- Sequencing, luciferase assays, RNA immunoprecipitation, and in situ hybridization to show that a bacteriocyte- distributed MRP4 gene (multidrug resistance- associated protein 4) is negatively regulated by a host (aphid)- specific microRNA (miR- 30...