Proceedings of the National Academy of Sciences of the United States of America

最新文章

• The miseries that remain may yet be alleviated AI翻译
  作者：Arslan, Ruben C.
  作者单位：Leipzig University
• Magnetically oriented nanosheet interlayer for dynamic regeneration in lithium metal batteries AI翻译
  作者：Ju, Zhengyu; Zheng, Tianrui; Zhang, Bowen; Dolocan, Andrei; Marschilok, Amy C.; Takeuchi, Esther S.; Takeuchi, Kenneth J.; Yu, Guihua
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University; United States Department of Energy (DOE); Brookhaven National Laboratory; State University of New York (SUNY) System; Stony Brook University
  摘要：Lithium (Li) metal has been recognized as a promising anode to advance the energy density of current Li-based batteries. However, the growth of the solid-electrolyte interphase (SEI) layer and dendritic Li microstructure pose significant challenges for the long-term operation of Li metal batteries (LMBs). Herein, we propose the utilization of a suspension electrolyte with dispersed magnetically responsive nanosheets whose orientation can be manipulated by an external magnetic field during cell...
• FlaG competes with FliS-flagellin complexes for access to FlhA in the flagellar T3SS to control Campylobacterjejuni filament length AI翻译
  作者：Waller, Alexis A.; Ribardo, Deborah A.; Hendrixson, David R.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center
  摘要：Bacteria power rotation of an extracellular flagellar filament for swimming motility. Thousands of flagellin subunits compose the flagellar filament, which extends several microns from the bacterial surface. It is unclear whether bacteria actively control filament length. Many polarly flagellated bacteria produce shorter flagellar filaments than peritrichous bacteria, and FlaG has been reported to limit flagellar filament length in polar flagellates. However, a mechanism for how FlaG may funct...
• Controlling for polygenic genetic confounding in epidemiologic association studies AI翻译
  作者：Zhao, Zijie; Yang, Xiaoyu; Dorn, Stephen; Miao, Jiacheng; Barcellos, Silvia H.; Fletcher, Jason M.; Lu, Qiongshi
  作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Southern California; University of Southern California; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
  摘要：Epidemiologic associations estimated from observational data are often confounded by genetics due to pervasive pleiotropy among complex traits. Many studies either neglect genetic confounding altogether or rely on adjusting for polygenic scores (PGS) in regression analysis. In this study, we unveil that the commonly employed PGS approach is inadequate for removing genetic confounding due to measurement error and model misspecification. To tackle this challenge, we introduce PENGUIN, a principl...
• Goblet cell differentiation subgroups in colorectal cancer AI翻译
  作者：Abdullayeva, Gulnar; Liu, Haoyu; Liu, Ta- Chun; Simmons, Alison; Novelli, Marco; Huseynova, Irada; Lastun, Viorica L.; Bodmer, Walter
  作者单位：University of Oxford; University of Oxford; Tencent; University of Oxford; University of Oxford; University of London; University College London
  摘要：The poor prognosis of relatively undifferentiated cancers has long been recognized, suggesting that selection against differentiation and in favor of uncontrolled growth is one of the most powerful drivers of cancer progression. Goblet cells provide the mucous surface of the gut, and when present in colorectal cancers (CRC), the cancers are called mucinous. We have used the presence of MUC2, the main mucous product of goblet cells, and an associated gene product, TFF3, to classify a large pane...
• Acceleration is the key to drag reduction in turbulent flow AI翻译
  作者：Ding, Liuyang; Sabidussi, Lena F.; Holloway, Brian C.; Hultmark, Marcus; Smits, Alexander J.
  作者单位：Princeton University; Intellectual Ventures
  摘要：A turbulent pipe flow experiment was conducted where the surface of the pipe was oscillated azimuthally over a wide range of frequencies, amplitudes, and Reynolds numbers. The drag was reduced by as much as 35%. Past work has suggested that the drag reduction scales with the velocity amplitude of the motion, its period, and/or the Reynolds number. Here, we find that the key parameter is the acceleration, which greatly simplifies the complexity of the phenomenon. This result is shown to apply t...
• Sensors in the microvascular web: Vital but vulnerable AI翻译
  作者：Lacoste, Baptiste
  作者单位：University of Ottawa; Ottawa Hospital Research Institute; University of Ottawa; University of Ottawa
• BLNK negatively regulates innate antifungal immunity through inhibiting c- Cbl- mediated macrophage migration AI翻译
  作者：Yang, Yi-Heng; Xie, Ke-Fang; Yang, Shuai; Wang, Huan; Ma, Hui-Hui; Zhou, Min; Wang, Zhong-Wei; Gu, Yebo; Jia, Xin-Ming
  作者单位：Tongji University; Tongji University; China Pharmaceutical University; Tongji University; Tongji University
  摘要：B cell linker protein (BLNK) is crucial for orchestrating B cell receptor- associated spleen tyrosine kinase (Syk) signaling. However, the role of BLNK in Syk- coupled C- type lectin receptor (CLR) signaling in macrophages remains unclear. Here, we delineate that CLRs govern the Syk- mediated activation of BLNK, thereby impeding macrophage migration by disrupting podosome ring formation upon stimulation with fungal beta- glucans or alpha- mannans. Mechanistically, BLNK instigates its associati...
• Molecular forecasting of toxic bloom events AI翻译
  作者：Alexander, Harriet
  作者单位：Woods Hole Oceanographic Institution
• Formation of hierarchically structured martensites in pure iron with ultrahigh strength and stiffness AI翻译
  作者：Gu, Chao; Chen, Haiyan; Zhao, Yusheng; Wang, Shanmin
  作者单位：Southern University of Science & Technology; State University of New York (SUNY) System; Stony Brook University; Eastern Institute of Technology, Ningbo
  摘要：Strong steels are primarily fabricated by introducing spatial obstacles (e.g., stacking faults and precipitates) that inhibit dislocation slips under stress to achieve high strength. However, for most low- carbon steels, such obstacles are difficult to form mainly because the martensitic transition is kinetically unfavorable by conventional methods, which precludes the attainment of high- strength materials in these steels with low solute contents. Here, we report an innovative high- pressure ...