Proceedings of the National Academy of Sciences of the United States of America

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• Long- term exposure to wildland fire smoke PM2.5 and mortality in the contiguous United States AI翻译
  作者：Ma, Yiqun; Zang, Emma; Liu, Yang; Wei, Jing; Lu, Yuan; Krumholz, Harlan M.; Bell, Michelle L.; Chen, Kai
  作者单位：Yale University; Yale University; Yale University; Emory University; Rollins School Public Health; University System of Maryland; University of Maryland College Park; Yale University; Yale University; Yale University
  摘要：Despite the substantial evidence on the health effects of short- term exposure to ambient fine particles (PM2.5), including increasing studies focusing on those from wildland fire smoke, the impacts of long- term wildland fire smoke PM 2.5 exposure remain unclear. We investigated the association between long- term exposure to wildland fire smoke PM 2.5 and nonaccidental mortality and mortality from a wide range of specific causes in all 3,108 counties in the contiguous United States, 2007 to 2...
• Topology, dynamics, and control of a muscle-architected soft arm AI翻译
  作者：Tekinalp, Arman; Naughton, Noel; Kim, Seung Hyun; Halder, Udit; Gillette, Rhanor; Mehta, Prashant G.; Kier, William; Gazzola, Mattia
  作者单位：Virginia Polytechnic Institute & State University; State University System of Florida; University of South Florida; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of North Carolina; University of North Carolina Chapel Hill; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Muscular hydrostats, such as octopus arms or elephant trunks, lack bones entirely, endowing them with exceptional dexterity and reconfigurability. Key to their unmatched ability to control nearly infinite degrees of freedom is the architecture into which muscle fibers are weaved. Their arrangement is, effectively, the instantiation of a sophisticated mechanical program that mediates, and likely facilitates, the control and realization of complex, dynamic morphological reconfigurations. Here, b...
• Reply to Yu et al.: Atmospheric circulation changes are more important in shaping the aerosol- induced Northeast Pacific warming pattern AI翻译
  作者：Wang, Hai; Zheng, Xiao- Tong; Cai, Wenju
  作者单位：Ocean University of China
• Nuclear dualism without extensive DNA elimination in the ciliate Loxodes magnus AI翻译
  作者：Seah, Brandon K. B.; Singh, Aditi; Vetter, David E.; Emmerich, Christiane; Peters, Moritz; Soltys, Volker; Huettel, Bruno; Swart, Estienne C.
  作者单位：Max Planck Society; Johann Heinrich von Thunen Institute; Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; Max Planck Society
  摘要：Most eukaryotes have one nucleus and nuclear genome per cell. Ciliates have instead evolved distinct nuclei that coexist in each cell: a silent germline vs. transcriptionally active somatic nuclei. In the best- studied model species, both nuclei can divide asexually, but only germline nuclei undergo meiosis and karyogamy during sex. Thereafter, thousands of DNA segments, called internally eliminated sequences (IESs), are excised from copies of the germline genomes to produce the streamlined so...
• Genetic variation drives cancer cell adaptation to ECM stiffness AI翻译
  作者：Wang, Ting - Ching; Sawhney, Suchitaa; Morgan, Daylin; Bennett, Richard L.; Rashmi, Richa; Estecio, Marcos R.; Brock, Amy; Singh, Irtisha; Baer, Charles F.; Licht, Jonathan D.; Lele, Tanmay P.
  作者单位：Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; University of Texas System; University of Texas Austin; State University System of Florida; University of Florida; Texas A&M University System; Texas A&M University College Station; University of Texas System; UTMD Anderson Cancer Center; State University System of Florida; University of Florida; Texas A&M University System
  摘要：The progression of many solid tumors is accompanied by temporal and spatial changes in the stiffness of the extracellular matrix (ECM). Cancer cells adapt to soft and stiff ECM through mechanisms that are not fully understood. It is well known that there is significant genetic heterogeneity from cell to cell in tumors, but how ECM stiffness as a parameter might interact with that genetic variation is not known. Here, we employed experimental evolution to study the response of genetically varia...
• Gold nanorod-assisted theranostic solution for nonvisible residual disease in bladder cancer AI翻译
  作者：Armanetti, Paolo; Locatelli, Irene; Venegoni, Chiara; Alchera, Elisa; Campanella, Beatrice; Pederzoli, Filippo; Maturi, Mirko; Locatelli, Erica; Tortorella, Silvia; Curnis, Flavio; Corti, Angelo; Luciano, Roberta; Onor, Massimo; Salonia, Andrea; Montorsi, Francesco; Moschini, Marco; Popov, Viktor; Jose, Jithin; Franchini, Mauro Comes; Ooi, Ean Hin; Menichetti, Luca; Alfano, Massimo
  作者单位：Consiglio Nazionale delle Ricerche (CNR); Consiglio Nazionale delle Ricerche (CNR); Vita-Salute San Raffaele University; University of Bologna; Fujifilm Corporation; Monash University; Monash University Malaysia
  摘要：Residual nonvisible bladder cancer after proper treatment caused by technological and therapeutic limitations is responsible for tumor relapse and progression. This study aimed to demonstrate the feasibility of a solution for simultaneous detection and treatment of bladder cancer lesions smaller than one millimeter. The alpha 5f31 integrin was identified as a specific marker in 81% of human high- grade nonmuscle invasive bladder cancers and used as a target for the delivery of targeted gold na...
• Climate, demography, immunology, and virology combine to drive two decades of dengue virus dynamics in Cambodia AI翻译
  作者：Brook, Cara E.; Rozins, Carly; Bohl, Jennifer A.; Ahyong, Vida; Chea, Sophana; Fahsbender, Liz; Huy, Rekol; Lay, Sreyngim; Leang, Rithea; Li, Yimei; Lon, Chanthap; Man, Somnang; Oum, Mengheng; Northrup, Graham R.; Oliveira, Fabiano; Pacheco, Andrea R.; Parker, Daniel M.; Young, Katherine; Boots, Michael; Tato, Cristina M.; Derisi, Joseph L.; Yek, Christina; Manning, Jessica E.
  作者单位：University of Chicago; York University - Canada; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Chan Zuckerberg Initiative (CZI); Chan Zuckerberg Initiative (CZI); National Center Parasitology, Entomology & Malaria Control; University of California System; University of California Berkeley; University of California System; University of California Irvine; University of California System; University of California Irvine; University of Texas System; University of Texas El Paso; University of California System; University of California Berkeley
  摘要：The incidence of dengue virus disease has increased globally across the past half- century, with highest number of cases ever reported in 2019 and again in 2023. We analyzed climatological, epidemiological, and phylogenomic data to investigate drivers of two decades of dengue in Cambodia, an understudied endemic setting. Using epidemiological models fit to a 19- y dataset, we first demonstrate that climate- driven transmission alone is insufficient to explain three epidemics across the time se...
• Computational detection of antigen-specific B cell receptors following immunization AI翻译
  作者：Abbate, Maria Francesca; Dupic, Thomas; Vigne, Emmanuelle; Shahsavarian, Melody A.; Walczak, Aleksandra M.; Mora, Thierry
  作者单位：Universite PSL; Ecole Normale Superieure (ENS); Sorbonne Universite; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Sanofi-Aventis; Sanofi France; Harvard University
  摘要：B cell receptors (BCRs) play a crucial role in recognizing and fighting foreign antigens. High-throughput sequencing enables in-depth sampling of the BCRs repertoire after immunization. However, only a minor fraction of BCRs actively participate in any given infection. To what extent can we accurately identify antigen-specific sequences directly from BCRs repertoires? We present a computational method grounded on sequence similarity, aimed at identifying statistically significant responsive BC...
• DOT1L-mediated RAP80 methylation promotes BRCA1 recruitment to elicit DNA repair AI翻译
  作者：Tang, Huangqi; Lu, Ya-Fei; Zeng, Rongsheng; Liu, Chaohua; Shu, Yuxin; Wu, Yupei; Su, Jiajie; Di, Longjiang; Qian, Jinqin; Zhang, Jun; Tian, Yuan; Lu, Xiaopeng; Pei, Xin-Hai; Zhu, Qian; Zhu, Wei-Guo
  作者单位：Shenzhen University; Shenzhen University; Fudan University; Shenzhen University
  摘要：Breast Cancer Type 1 Susceptibility Protein (BRCA1) is a tumor- suppressor protein that regulates various cellular pathways, including those that are essential for preserving genome stability. One essential mechanism involves a BRCA1-A complex that is recruited to double- strand breaks (DSBs) by RAP80 before initiating DNA damage repair (DDR). How RAP80 itself is recruited to DNA damage sites, however, is unclear. Here, we demonstrate an intrinsic correlation between a methyltransferase DOT1L-...
• Light regulates widespread plant alternative polyadenylation through the chloroplast AI翻译
  作者：Kubaczka, M. Guillermina; Herz, Micaela A. Godoy; Chen, Wei- Chun; Zheng, Dinghai; Petrillo, Ezequiel; Tan, Bin; Kornblihtt, Alberto R.
  作者单位：University of Buenos Aires; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University of Buenos Aires; CONICET UBA; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; The Wistar Institute; The Wistar Institute
  摘要：Transcription of eukaryotic protein- coding genes generates immature mRNAs that are subjected to a series of processing events, including capping, splicing, cleavage, and polyadenylation (CPA), and chemical modifications of bases. Alternative polyadenylation (APA) greatly contributes to mRNA diversity in the cell. By determining the length of the 3' untranslated region, APA generates transcripts with different regulatory elements, such as miRNA and RBP binding sites, which can influence mRNA s...