Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Population size interacts with reproductive longevity to shape the germline mutation rate (vol 122, e2423311122, 2025) AI翻译
  作者：Zhu, Luke; Beichman, Annabel; Harris, Kelley
• Epigenetic cellular memory in Pseudomonas aeruginosa generates phenotypic variation in response to host environments AI翻译
  作者：Vatareck, Elisabeth; Rick, Tim; Gomez, Nicolas Oswaldo; Bandyopadhyay, Arnab; Kramer, Janina; Strunin, Dmytro; Erdmann, Jelena; Hartmann, Oliver; Alpers, Kathrin; Boedeker, Christian; Steffen, Anika; Sieben, Christian; Zhao, Gang; Tomasch, Juergen; Haeussler, Susanne
  作者单位：Helmholtz Association; Helmholtz-Center for Infection Research; Hannover Medical School; Helmholtz Association; Helmholtz-Center for Infection Research; University of Copenhagen; Copenhagen University Hospital; Rigshospitalet; Helmholtz Association; Helmholtz-Center for Infection Research; Helmholtz Association; Helmholtz-Center for Infection Research; Helmholtz Association; Helmholtz-Center for Infection Research; Czech Academy of Sciences; Institute of Microbiology of the Czech Academy of Sciences; Hannover Medical School; AstraZeneca
  摘要：Phenotypic diversification within pathogen populations can enhance survival in stressful environments, broaden niche colonization, and expand the ecological range of infectious diseases due to emerging collective pathogenicity characteristics. We describe a gene regulatory network property in the opportunistic pathogen Pseudomonas aeruginosa that generates diversity of gene expression and pathogenicity behavior at the single-cell level and that is stabilized by epigenetic cellular memory. The ...
• Comparing conventional and alternative mechanisms of discovering and accessing the scientific literature AI翻译
  作者：Walters, William H.
  作者单位：Southern Illinois University System; Southern Illinois University
  摘要：This study compares the bibliographic and full- text coverage of 15 conventional and and the Web of Science Core Collection), five single- subject databases, the integrated Scholar), two web- based scholarly databases (Dimensions and OpenAlex), two academic and Sci- Hub). The analysis is based on known- item searches for 875 target documents chology. Overall, Google Scholar, OpenAlex, and the ILS are the most comprehensive sources of bibliographic records. Google Scholar's coverage rate is hig...
• Reply to Ferraro et al.: Breed-and-feed reflects inevitable trade-offs between individual longevity and population sustainability AI翻译
  作者：Clauss, Marcus; Roller, Marco; Bertelsen, Mads F.; von Rohr, Claudia Rudolf; Mueller, Dennis W. H.; Schiffmann, Christian; Kummrow, Maya; Encke, Dag; Ferreira, Sam; Duvall, Ethan S.; Mare, Celeste; Abraham, Andrew J.
  作者单位：University of Zurich; University of Copenhagen; North West University - South Africa; Cornell University; Aarhus University; Northern Arizona University
• Calcineurin targets that mediate Cryptococcus thermotolerance AI翻译
  作者：Mitchell, Aaron P.
  作者单位：University System of Georgia; University of Georgia
• Collective cooperative intelligence AI翻译
  作者：Barfuss, Wolfram; Flack, Jessica; Gokhale, Chaitanya S.; Hammond, Lewis; Hilbe, Christian; Hughes, Edward; Leibo, Joel Z.; Lenaerts, Tom; Leonard, Naomi; Levin, Simon; Sehwag, Udari Madhushani; Mcavoy, Alex; Meylahn, Janusz M.; Santos, Fernando P.
  作者单位：University of Bonn; The Santa Fe Institute; Max Planck Society; University of Wurzburg; University of Oxford; Alphabet Inc.; Google Incorporated; DeepMind; Universite Libre de Bruxelles; Vrije Universiteit Brussel; Princeton University; Princeton University; Stanford University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Twente; University of Amsterdam
  摘要：Cooperation at scale is critical for achieving a sustainable future for humanity. However, achieving collective, cooperative behavior-in which intelligent actors in complex environments jointly improve their well-being-remains poorly understood. Complex systems science (CSS) provides a rich understanding of collective phenomena, the evolution of cooperation, and the institutions that can sustain both. Yet, much of the theory in this area fails to fully consider individual-level complexity and ...
• QnAs with Anne K. Churchland AI翻译
  作者：Hardcastle, Matthew
• Why decoding the elite soccer player's psychological profile fails to score AI翻译
  作者：Musculus, Lisa; Araujo, Duarte; Bisagno, Elisa; Kalen, Anton; Gustafsson, Henrik; Perez-Ferreiros, Alexandra; Lindwall, Magnus; Raab, Markus; Williams, A. Mark; Stenling, Andreas
  作者单位：German Sport University Cologne; Universidade de Lisboa; Universita di Modena e Reggio Emilia; Norwegian School of Sport Sciences; Karlstad University; Lulea University of Technology; University of Gothenburg; Utah System of Higher Education; University of Utah; Umea University; University of Agder
• Keratinocyte-TRPV 1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch AI翻译
  作者：Crowther, Andrew J.; Kashem, Sakeen W.; Jewell, Madison E.; Le Chang, Henry; Midavaine, Elora; Casillas, Mariela Rosa; Danchine, Veronika; Rodriguez, Sian; Kania, Artur; Chen, Ritchie; Braz, Joao M.; Basbaum, Allan I.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; Institut de Recherche Clinique de Montreal (IRCM); Universite de Montreal; University of California System; University of California San Francisco
  摘要：Our understanding of neural circuits that respond to skin dysfunction, triggering itch, and pathophysiological scratching remains incomplete. Here, we describe a profound chronic itch phenotype in transgenic mice expressing the tetracycline transactivator (tTA) gene within the Phox2a lineage. Phox2a; tTA mice exhibit intense, localized scratching and regional skin lesions, controllable by the tTA inhibitor, doxycycline. As gabapentin and the kappa opioid receptor agonist, nalfurafine, but not ...
• N6-methyladenosine modification of HCMV IE1 transcript promotes the repressive state of viral genome to achieve latent infection AI翻译
  作者：Jeong, Heena; Yeo, Nagyeong; Hwang, Hyeonseo; Park, Junhyun; Baek, Daehyun; Ahn, Kwangseog
  作者单位：Seoul National University (SNU); Institute for Basic Science - Korea (IBS); Seoul National University (SNU)
  摘要：Human cytomegalovirus (HCMV) is a prevalent pathogen that chronically infects the majority of human population. Among the many features that allow such widespread HCMV infection, one is its ability to maintain a transcriptionally dormant immune-evasive state called latency by suppressing its own major immediate early promoter (MIEP) via epigenetic alterations. In this study, we show a mechanism of MIEP regulation in which the major immediate early (MIE) gene product, immediate early 1 (IE1) tr...