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作者：Zhao, Xiao-Cong; Wu, Bin; Yang, Ya -Jun; Li, Ying; Qiu, Qi -Yuan; Wang, Liu; Xu, Ya -Peng; Gong, Han; Song, Lun; Wang, Xue -Jie; Shi, Jing -Yao; Chen, Xue -Feng; Zhang, Shao -Ran; Zong, Qi; Dai, Liang; Du, Shi -Shen; Zhang, Yan; Wu, Wen -Qiang; Zhang, Xing -Hua
作者单位：Wuhan University; City University of Hong Kong; Henan University; Huazhong Agricultural University; Wuhan University
摘要：Both DNA methylation and homologous recombination (HR) are extensively studied. In bacteria, Dam methylation is the most studied DNA modification, while RecA-mediated HR is a primary mechanism to repair DNA damages including double-stranded breaks, single-stranded gaps, and stalled replication forks. While HR regulation by proteins is extensively studied, whether methylation of DNA itself directly affects the functions of RecA and HR remains unclear. Mainly by single-molecule experiments, we r...
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作者：Bassiouni, Maoya; Smith, Nicholas G.; Reu, Jacqueline C.; Penuelas, Josep; Keenan, Trevor F.
作者单位：University of California System; University of California Berkeley; Texas Tech University System; Texas Tech University; Autonomous University of Barcelona; Consejo Superior de Investigaciones Cientificas (CSIC); Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：Widespread evidence of decreasing leaf nutrients has raised concerns about ecosystem productivity under global change. Interpreting trends in leaf nutrients has important implications for the fate of ecosystem services, particularly the role of forests in mitigating climate change and sustaining quality food sources. Here, we challenge the common interpretation that decreasing leaf nitrogen concentration (LNC) is evidence of increasing nutrient limitations on ecosystem primary productivity.Ins...
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作者：Georgiou, Dimitrios; Sun, Danqi; Liu, Xing; Athanasiou, Christos E.
作者单位：University System of Georgia; Georgia Institute of Technology; New Jersey Institute of Technology
摘要：Over 350 million metric tons of plastic waste are generated annually, with most ending up in landfills, dumps, or the environment, posing significant risks. Mechanical recycling remains underutilized, largely due to the high variability in the mechanical properties of recycled plastics (recyclates). This variability undermines performance reliability and hinders the adoption of recyclates in demanding industrial applications. Inspired by natural materials, known for their mechanical robustness...
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作者：Pederson, Thoru
作者单位：University of Massachusetts System; University of Massachusetts Worcester; UMass Chan Medical School
摘要：Having trained as a physician, & Eacute;tienne-& Eacute;mile Baulieu soon turned his focus to research, as early as his medical internship. He went on to make major contributions on ketosteroids and other steroids, such as estrogen, and how they act on target organs through receptors to which the hormones bind and activate physiological responses. Later, he consulted with a French pharmaceutical company, encouraging them to pursue his concept for an antigestational agent, which became the icon...
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作者：Dai, Gaole; Qu, Teng; Lei, Min; Li, Zhuo; Yang, Fubao; Zhang, Ziwei; Wang, Yuanyuan; Xie, Huaqing; Huang, Jiping; Wang, Jun
作者单位：Nantong University; Fudan University; Fudan University; Shanghai Polytechnic University; University of Shanghai for Science & Technology
摘要：Diffusion in physical, chemical, and biological systems often occurs under transient conditions and involves coupling across multiple physical fields, challenging conventional control methods limited to steady-state, single-field settings. Here, we present a general geometric framework for regulating diffusion in time-dependent and multiphysics-coupled environments based on pseudoconformal mapping. This method preserves material isotropy and ensures smooth interface matching, enabling robust a...
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作者：Zhao, Zihe; Li, Ao; Zhu, Yan; Cen, Shaoqin; Liu, Qing; Zhang, Yuan; Fan, Hanqi; Hou, Zhenxing; Ma, Dengbin; Liu, Dingding; Duan, Maoli; Qian, Xiaoyun; Chai, Renjie; Wan, Guoqiang; Gao, Xia
作者单位：Nanjing University; Nanjing University; Nanjing University; Nanjing Medical University; Nanjing University; Nanjing University; Karolinska Institutet; Karolinska University Hospital; Karolinska Institutet; Southeast University - China
摘要：Hearing loss (HL) in patients with systemic lupus erythematosus (SLE) has been widely reported, though the underlying mechanisms remain unclear. In this study, we demonstrate significant HL in an imiquimod-induced mouse model of SLE, accompanied by CD8+ T lymphocytes and natural killer cells mediate BLB disruption, with granzyme b (Gzmb) acting as the primary factor inducing cell death of the cochlear capillary endotheof hearing thresholds in imiquimod-induced SLE model mice, suggesting a ther...
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作者：Agrawal, Rachana; Seager, Sara; Iakubivskyi, Iaroslav; Buchanan, Weston P.; Glidden, Ana; Seager, Maxwell D.; Bains, William; Huang, Jingcheng; Petkowski, Janusz J.
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); University of Tartu; Tartu Observatory; Cardiff University; Wroclaw University of Science & Technology
摘要：The discovery of thousands of exoplanets and the emergence of telescopes capable of exoplanet atmospheric characterization have intensified the search for habitable worlds. Due to selection biases, many exoplanets under study are planets deemed inhospitable because their surfaces are too warm to support liquid water. We propose that such planets could still support life through ionic liquids: Liquid salts with negligible vapor pressure that can persist on warm planets with thin atmospheres, wh...
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作者：Belanger, Sebastien; Martin, Azahara C.; Marchant, D. Blaine; Zhan, Junpeng; McGregor, Madison; Smedley, Mark; Hayta, Sadiye; Moore, Graham; Meyers, Blake C.
作者单位：Donald Danforth Plant Science Center; James Hutton Institute; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Agricultura Sostenible (IAS); University of Missouri System; University of Missouri Saint Louis; Huazhong Agricultural University; Huazhong Agricultural University; Hubei Hongshan Laboratory; University of California System; University of California Davis; University of California System; University of California Davis
摘要：Reproductive, male-enriched small RNAs are present in flowering plants and animals, yet their role in plants remains underexplored. We generated dicer-like 5 (dcl5) mutants in durum wheat (Triticum turgidum ssp. durum 2n = 4x = 28; AABB), revealing temperature-sensitive genic male sterility. Loss of DCL5 depleted premeiotic and meiotic 24-nt phasiRNA production, correlating with sterility under standard growth conditions and partial fertility recovery at higher temperatures. A single functiona...
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作者：Mas- Herrero, Ernest; Marco- Pallares, Josep
作者单位：University of Barcelona; Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Hospital Duran i Reynals
摘要：Current models suggest that musical pleasure is tied to the intrinsic reward of learning, as it relies on predictive processes that challenge our minds. According to predictive coding, optimal learning, which maximizes epistemic value, depends on balancing predictability and uncertainty, implying that musical pleasure should also reflect this equilibrium. We tested this idea in two independent large samples using a novel decision- making paradigm, where participants indicated preferences for m...
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作者：Montegut, Lea; Lambertucci, Flavia; Moledo-Nodar, Lucas; Fiuza-Luces, Carmen; Rodriguez-Lopez, Carlos; Serra-Rexach, Jose Antonio; Lachkar, Sylvie; Motino, Omar; Abdellatif, Mahmoud; Durand, Sylvere; Aprahamian, Fanny; Carbonnier, Vincent; Le Corre, Delphine; Richard, Sophie Mouillet-; Chen, Hui; Sauvat, Allan; Dong, Yanbing; Li, Sijing; Rong, Yan; Pietrocola, Federico; Puig, Pierre Laurent-; Lopez-Otin, Carlos; Martins, Isabelle; Barcena, Clea; Lucia, Alejandro; Kroemer, Guido
作者单位：Universite Paris Cite; Institut Universitaire de France; Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; UNICANCER; Gustave Roussy; University of Oviedo; Instituto de Salud Carlos III; General University Gregorio Maranon Hospital; Complutense University of Madrid; Universidad de Valladolid; Medical University of Graz; Institut Universitaire de France; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Karolinska Institutet; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Europeen Georges-Pompidou - APHP; Universidad Antonio de Nebrija; European University of Madrid; Icahn School of Medicine at Mount Sinai
摘要：The tissue hormone acyl coenzyme A-binding protein (ACBP, encoded by the gene diazepam-binding inhibitor, DBI) has been implicated in various facets of pathological aging. Here, we show that ACBP plasma concentrations are elevated in (close-to-)centenarians (mean +/- SD age 99.5 +/- 4.5 y) commensurate with their health deterioration, correlating with a reduced glomerular filtration rate and a surge in senescence-associated cytokines. ACBP neutralization by means of a monoclonal antibody (mAb)...
