Proceedings of the National Academy of Sciences of the United States of America

最新文章

• The Medicago truncatula lncRNA ENOD40 is a mediator of microRNA169- controlled NF-YA activity in nodule initiation AI翻译
  作者：Wijsman, Tristan; Mohd-Radzman, Nadia A.; Liu, Jieyu; Oldroyd, Giles E. D.; Kohlen, Wouter; Kulikova, Olga; Heidstra, Renze; Scheres, Ben; Franssen, Henk J.
  作者单位：Wageningen University & Research; University of Cambridge; University of Cambridge
  摘要：The hallmark of the legume lncRNA EARLY NODULIN40 (ENOD40), involved in rhizobium- induced nodulation, is the presence of a highly conserved stretch of 24 nucleotides, designated box2, preceded by a small open- reading- frame (sORF) coding for a peptide of 12 to 13 amino acids. Although there is a well- established link between ENOD40 and nodulation, it is not fully clear by which mechanism ENOD40 functions in this process. Here, we show that a region harboring box2 can complement nodule forma...
• Our current climate already merits serious research and policy attention AI翻译
  作者：Obradovich, Nick; Lawrance, Emma L.; Minor, Kelton
  作者单位：Laureate Institute for Brain Research, Inc.; Massachusetts Institute of Technology (MIT); University of Tulsa; Imperial College London; Imperial College London; Columbia University; University of Copenhagen
• Some topological genera and Jacobi forms AI翻译
  作者：Amdeberhan, Tewodros; Griffin, Michael J.; Ono, Ken
  作者单位：Tulane University; Vanderbilt University; University of Virginia
  摘要：We revisit and elucidate the A-genus, Hirzebruch's L-genus, and Witten's W-genus, cobordism invariants of special classes of manifolds. After slight modification, involving Hecke's trick, we find that the A-genus and L-genus arise directly from Jacobi's theta function. For every k >= 0, we obtain exact formulas for the quasimodular expressions of A(k) and L-k as traces of partition Eisenstein series A(K)(tau ) = Tr-k(Phi(A):tau) and L-k(tau) = Tr-k (Phi(L):tau) which are easily converted to th...
• Transcription termination promotes splicing efficiency and fidelity in a compact genome AI翻译
  作者：Barr, Keaton; He, Kevin L.; Krumbein, Andreas J.; Chanfreau, Guillaume F.
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
  摘要：Splicing of terminal introns is coupled to 3 '-end processing by cleavage and polyadenylation (CPA) in mammalian genes. Whether this functional coupling is universally conserved across eukaryotes is unclear. Here, we show using long read RNA sequencing in Saccharomyces cerevisiae that splicing inactivation does not result in widespread CPA impairment, and that inactivation of CPA has limited impact on splicing efficiency. The negative impact of CPA inactivation on splicing is mainly due to tra...
• Tracing SARS-CoV-2 clusters across local scales using genomic data AI翻译
  作者：Lyu, Leke; Gill, Mandev; Stott, Guppy; Subedi, Sachin; Dailey, Cody; Veytsel, Gabriella; Alabady, Magdy; Fujimoto, Kayo; Penn, Ryker; Brown, Pamela; Sealy, Roger; Bahl, Justin
  作者单位：University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University of Texas System; University of Texas Health Science Center Houston
  摘要：A quantitative understanding of local transmission dynamics is essential for designing effective prevention strategies. In this study, we developed a computational workflow to identify viral introductions and trace locally circulating clusters. We analyzed over 26,000 SARS-CoV-2 genomes and their associated metadata, collected between January and October 2021, to explore introduction and local dispersal patterns in Greater Houston, a major metropolitan area known for its demographic diversity....
• Gaming the cancer-immunity cycle by synchronizing the dose schedules AI翻译
  作者：Mahmoodifar, Saeedeh; Stuckey, Kristina; Newton, Paul K.
  作者单位：University of Southern California; University of Southern California; University of Southern California; University of Southern California; University of Southern California
  摘要：We introduce a mathematical model of the cancer-immunity cycle and use it to test several hypotheses regarding the combination, timing, and optimization associated with chemotherapy and immunotherapy dosing schedules in the context of competition and time-dependent selection pressure. A key idea is the value of synchronizing the dosing schedules with the fundamental period of the cancer-immunity cycle. The competitors in the population dynamics evolutionary game are the cancer cells, healthy (...
• CRISPR-Cas9 screening reveals microproteins regulating adipocyte proliferation and lipid metabolism AI翻译
  作者：Pai, Victor J.; Shan, Huanqi; Donaldson, Cynthia J.; Vaughan, Joan M.; De Souza, Eduardo V.; O'Connor, Carolyn; Liem, Michelle; Pinto, Antonio F. M.; Diedrich, Jolene; Saghatelian, Alan
  作者单位：Salk Institute; Salk Institute; Scripps Research Institute
  摘要：Small open reading frames (smORFs) encode microproteins that play crucial roles in various biological processes, yet their functions in adipocyte biology remain largely unexplored. In a previous study, we identified thousands of smORFs in white and brown adipocytes derived from the stromal vascular fraction of mice using ribosome profiling. Here, we expand on this work by identifying additional smORFs related to adipocytes using the in vitro 3T3-L1 preadipocyte model. To systematically investi...
• Tuning Fermi liquids with polaritonic cavities AI翻译
  作者：Riolo, Riccardo; Tomadin, Andrea; Mazza, Giacomo; Asgari, Reza; Macdonald, Allan H.; Polini, Marco
  作者单位：University of Pisa; Zhejiang Normal University; Institute for Research in Fundamental Sciences IPM; University of Texas System; University of Texas Austin; Barcelona Institute of Science & Technology; Universitat Politecnica de Catalunya; Institut de Ciencies Fotoniques (ICFO)
  摘要：The question of whether or not passive subwavelength cavities can alter the properties of quantum materials is currently attracting a great deal of attention. In this article, we show that the Fermi liquid parameters of a two-dimensional metal are modified by cavity polariton modes, and that these changes can be monitored by measuring a paradigmatic magneto-transport phenomenon, Shubnikov-de Haas oscillations in a weak perpendicular magnetic field. This effect is intrinsic, and totally unrelat...
• Predictability and the pleasure of music AI翻译
  作者：Belfi, Amy M.
  作者单位：University of Missouri System; Missouri University of Science & Technology
• Structural insights into proteolysis-dependent and-independent suppression of the master regulator DELLA by the gibberellin receptor AI翻译
  作者：Dahal, Pawan; Wang, Yan; Hu, Jianhong; Sharma, Kedar; Park, Jeongmoo; Forker, Karly; Zhang, Zhong -Lin; Borgnia, Mario J.; Sun, Tai-ping; Zhou, Pei
  作者单位：Duke University; Duke University; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); Syngenta
  摘要：The perception of the phytohormone gibberellin (GA) by its nuclear receptor GIBBERELLIN INSENSITIVE DWARF1 (GID1) triggers polyubiquitination and proteasomal degradation of master growth regulators-DELLA proteins-mediated by the SCFSLY1/GID2 E3 ubiquitin ligase complex. DELLA-encoding genes are known as 'Green Revolution' genes, as their dominant mutations lead to semidwarf cereal varieties with significantly higher yields due to reduced GA response. DELLAs function as central signaling hubs, ...