作者：Reynolds, Sam A.; Christie, Alec P.; Dicks, Lynn V.; Jaffer, Sadiq; Madhavapeddy, Anil; Smith, Rebecca K.; Sutherland, William J.
作者单位：University of Cambridge; Imperial College London; University of Cambridge; University of Cambridge; University of Cambridge
作者：Shi, Yixing; Sun, Qianqian; Jia, Fuchuan; Xie, Xiangyu; Zhou, Xiangyu; Guo, Rong; Zeng, Yangfan; Chen, Shanshan; Guo, Zhenzhen; Sun, Wenli; Guo, Tong; Xia, Yu; Li, Wenlong; Zhang, Li; Shi, Wei; Yu, Yang
作者单位：Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Chinese Institute for Brain Research, Beijing; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College
摘要：Chromosomal rearrangements and gene fusions are the initial events in the development of many cancers. Astroblastoma (ABM), a brain cancer of unknown cellular origin and challenging to treat, is associated with diverse in-frame gene fusions, including MN1-BEND2 and MN1-CXXC5 (refs. 1,2). However, it remains unclear whether these gene fusions contribute to tumorigenesis. Here we show in mice that these two ABM-associated fusions converge on similar molecular activities and initiate malignancy s...
作者：Elardo, Stephen M.
作者单位：State University System of Florida; University of Florida
作者：Yoshida, Tomomi M.; Nguyen, Mytien; Zhang, Le; Lu, Benjamin Y.; Zhu, Biqing; Murray, Katie N.; Mineur, Yann S.; Zhang, Cuiling; Xu, Di; Lin, Elizabeth; Luchsinger, Joseph; Bhatta, Sagar; Waizman, Daniel A.; Coden, Mackenzie E.; Ma, Yifan; Israni-Winger, Kavita; Russo, Anthony; Wang, Haowei; Song, Wenzhi; Al Souz, Jafar; Zhao, Hongyu; Craft, Joseph E.; Picciotto, Marina R.; Grutzendler, Jaime; Distasio, Marcello; Palm, Noah W.; Hafler, David A.; Wang, Andrew
作者单位：Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University
摘要：Specialized immune cells that reside in tissues orchestrate diverse biological functions by communicating with parenchymal cells1. The contribution of the innate immune compartment in the meninges and the central nervous system (CNS) is well-characterized; however, whether cells of the adaptive immune system reside in the brain and are involved in maintaining homeostasis is unclear2, 3-4. Here we show that the subfornical organ (SFO) of the brain is a nucleus for parenchymal alpha beta T cells...
