-
作者：Jones, Matthew
作者单位：University of Bath
-
作者：Reinhold, Kimberly; Iadarola, Marci; Tang, Shi; Chang, Annabel; Kuwamoto, Whitney; Albanese, Madeline A.; Sun, Senmiao; Hakim, Richard; Zimmer, Joshua; Wang, Wengang; Sabatini, Bernardo L.
作者单位：Harvard University; Harvard Medical School; Howard Hughes Medical Institute
摘要：Animals learn to carry out motor actions in specific sensory contexts to achieve goals. The striatum has been implicated in producing sensory-motor associations1, yet its contributions to memory formation and recall are not clear. Here, to investigate the contribution of the striatum to these processes, mice were taught to associate a cue, consisting of optogenetic activation of striatum-projecting neurons in visual cortex, with the availability of a food pellet that could be retrieved by fore...
-
作者：Haramia, Chelsea; Lafleche, Emilie A.; De Marines, Julia; Wong, Michael L.
作者单位：University of Bonn; Purdue University System; Purdue University; University of California System; University of California Berkeley; Carnegie Institution for Science
-
作者：Liao, Meimei; Liu, Yanqin; Xu, Zhancong; Fang, Mingxu; Yu, Ziqing; Cui, Yufan; Sun, Zhengda; Huo, Ran; Yang, Jieyu; Huang, Fusheng; Liu, Mingming; Zhou, Qin; Song, Xiaocui; Han, Hui; Chen, She; Xu, Xiaodong; Qin, Ximing; He, Qun; Ju, Dapeng; Wang, Tao; Thakkar, Nirav; Hardin, Paul E.; Golden, Susan S.; Zhang, Eric Erquan
作者单位：National Institute of Biological Sciences, Beijing; Tsinghua University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; University of California System; University of California San Diego; Tsinghua University; China Agricultural University; Henan University; Anhui University; Chongqing Medical University; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; University of California System; University of California San Diego
-
作者：ten Hietbrink, Sophie; Materic, Dusan; Holzinger, Rupert; Groeskamp, Sjoerd; Niemann, Helge
作者单位：Utrecht University; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); Utrecht University; Royal Netherlands Institute for Sea Research (NIOZ); Utrecht University; Stockholm University
摘要：Plastic pollution of the marine realm is widespread, with most scientific attention given to macroplastics and microplastics(1,2). By contrast, ocean nanoplastics (<1 mu m) remain largely unquantified, leaving gaps in our understanding of the mass budget of this plastic size class(3,4,5). Here we measure nanoplastic concentrations on an ocean-basin scale along a transect crossing the North Atlantic from the subtropical gyre to the northern European shelf. We find approximately 1.5-32.0 mg m(-3...
-
作者：Fang, Yinshan; Chung, Sanny S. W.; Xu, Le; Xue, Chenyi; Liu, Xue; Jiang, Dianhua; Li, Rongbo; Korogi, Yohei; Yuan, Ke; Saqi, Anjali; Hibshoosh, Hanina; Huang, Yuefeng; Lin, Chyuan-Sheng; Takarada, Takeshi; Tsukui, Tatsuya; Sheppard, Dean; Sun, Xin; Que, Jianwen
-
作者：McClune, Conor James; Liu, Jack Chun-Ting; Wick, Chloe; de la Pena, Ricardo; Lange, Bernd Markus; Fordyce, Polly M.; Sattely, Elizabeth S.
作者单位：Stanford University; Stanford University; Howard Hughes Medical Institute; Stanford University; Washington State University; Stanford University; Stanford University
摘要：Plants make complex and potent therapeutic molecules1,2, but sourcing these molecules from natural producers or through chemical synthesis is difficult, which limits their use in the clinic. A prominent example is the anti-cancer therapeutic paclitaxel (sold under the brand name Taxol), which is derived from yew trees (Taxus species)3. Identifying the full paclitaxel biosynthetic pathway would enable heterologous production of the drug, but this has yet to be achieved despite half a century of...
-
作者：Ma, Dongao; Pang, Jiaxuan; Gotway, Michael B.; Liang, Jianming
作者单位：Arizona State University; Arizona State University-Tempe; Mayo Clinic; Mayo Clinic Phoenix; Arizona State University; Arizona State University-Downtown Phoenix
摘要：Chest radiography frequently serves as baseline imaging for most lung diseases1. Deep learning has great potential for automating the interpretation of chest radiography2. However, existing chest radiographic deep learning models are limited in diagnostic scope, generalizability, adaptability, robustness and extensibility. To overcome these limitations, we have developed Ark+, a foundation model applied to chest radiography and pretrained by cyclically accruing and reusing the knowledge from h...
-
作者：Pearson, Helen
-
作者：Shi, Qiang; Chen, Yihan; Li, Yang; Qin, Shishang; Yang, Yu; Gao, Yang; Zhu, Linnan; Wang, Dongfang; Zhang, Zemin
作者单位：Peking University; Peking University; Chongqing Medical University; Shenzhen Bay Laboratory
摘要：The multicellular coordination that underlies tissue homeostasis and disease progression is of fundamental interest1, 2, 3, 4-5. However, how diverse cell types are organized within tissue niches for cohesive functioning remains largely unknown. Here we systematically characterized cross-tissue coordinated cellular modules in healthy tissues, uncovering their spatiotemporal dynamics and phenotypic associations, and examined their rewiring in cancer. We first compiled a comprehensive single-cel...
