作者：Gonzalez-Lozano, Miguel A.; Schmid, Ernst W.; Whelan, Enya Miguel; Jiang, Yizhi; Paulo, Joao A.; Walter, Johannes C.; Harper, J. Wade
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Howard Hughes Medical Institute
摘要：Early or sorting endosomes are dynamic organelles that play key roles in proteome control by triaging plasma membrane proteins for either recycling or degradation in the lysosome1,2. These events are coordinated by numerous transiently associated regulatory complexes and integral membrane components that contribute to organelle identity during endosome maturation3. Although a subset of the several hundred protein components and cargoes known to associate with endosomes have been studied at the...
作者：Grocott, Marcus C.; Gaunt, Matthew J.
作者单位：University of Cambridge
摘要：One-carbon homologues are structurally related and functionally identical organic molecules whose chain lengths differ by a single methylene (-CH2-) unit1. Across many classes of molecule-including pharmaceutical agents, natural products, agrochemicals, fragrances and petroleum products-the physicochemical characteristics exhibited by members of a homologous series subtly differ from one compound to another, which can impart remarkable differences to their function2. The efficient generation o...
作者：Jon, WooJung
作者单位：Korea Advanced Institute of Science & Technology (KAIST)
作者：Sayigh, Laela
作者单位：Woods Hole Oceanographic Institution
作者：De Los Angeles, Alejandro; Benvenisty, Nissim; Deng, Hongkui; Hanna, Jacob H.; Koplin, Julian; Li, Tianqing; Liu, Pentao; Loh, Yuin-Han; Pei, Duanqing; Sugimura, Ryohichi; Tam, Timothy Theodore Ka Ki; Tao, Tan; Trounson, Alan; Xu, Shao; Yu, Leqian; Zambidis, Elias; Zernicka-Goetz, Magdalena; Lovell-Badge, Robin
作者单位：Harvard University; Harvard Medical School; Hebrew University of Jerusalem; Peking University; Weizmann Institute of Science; Monash University; Kunming University of Science & Technology; University of Hong Kong; Agency for Science Technology & Research (A*STAR); A*STAR - Institute of Molecular & Cell Biology (IMCB); Westlake University; Monash University; Chinese Academy of Sciences; Johns Hopkins University; California Institute of Technology; Francis Crick Institute
摘要：The decades-old limit on how long human embryos can be grown in culture is under debate. A new road map outlines how to extend the length of culture responsibly.
