作者：Allentoft, Morten E.; Sikora, Martin; Fischer, Anders; Sjoegren, Karl-Goeran; Ingason, Andres; Macleod, Ruairidh; Rosengren, Anders; Schulz Paulsson, Bettina; Jorkov, Marie Louise Schjellerup; Novosolov, Maria; Stenderup, Jesper; Price, T. Douglas; Fischer Mortensen, Morten; Nielsen, Anne Birgitte; Ulfeldt Hede, Mikkel; Sorensen, Lasse; Nielsen, Poul Otto; Rasmussen, Peter; Jensen, Theis Zetner Trolle; Refoyo-Martinez, Alba; Irving-Pease, Evan K.; Barrie, William; Pearson, Alice; Sousa da Mota, Barbara; Demeter, Fabrice; Henriksen, Rasmus A.; Vimala, Tharsika; Mccoll, Hugh; Vaughn, Andrew; Vinner, Lasse; Renaud, Gabriel; Stern, Aaron; Johannsen, Niels Norkjaer; Ramsoe, Abigail Daisy; Schork, Andrew Joseph; Ruter, Anthony; Gotfredsen, Anne Birgitte; Henning Nielsen, Bjarne; Brinch Petersen, Erik; Kannegaard, Esben; Hansen, Jesper; Buck Pedersen, Kristoffer; Pedersen, Lisbeth; Klassen, Lutz; Meldgaard, Morten; Johansen, Morten; Uldum, Otto Christian; Lotz, Per; Lysdahl, Per; Bangsgaard, Pernille; Petersen, Peter Vang; Maring, Rikke; Iversen, Rune; Wahlin, Sidsel; Anker Sorensen, Soren; Andersen, Soren H.; Jorgensen, Thomas; Lynnerup, Niels; Lawson, Daniel J.; Rasmussen, Simon; Korneliussen, Thorfinn Sand; Kjaer, Kurt H.; Durbin, Richard; Nielsen, Rasmus; Delaneau, Olivier; Werge, Thomas; Kristiansen, Kristian; Willerslev, Eske
作者单位：University of Copenhagen; Curtin University; University of Kiel; University of Gothenburg; University of Copenhagen; Copenhagen University Hospital; University of Cambridge; University of London; University College London; University of Copenhagen; University of Wisconsin System; University of Wisconsin Madison; Lund University; University of Copenhagen; University of Cambridge; University of Lausanne; University of Lausanne; Swiss Institute of Bioinformatics; University of California System; University of California Berkeley; Technical University of Denmark; Aarhus University; Translational Genomics Research Institute; University of Copenhagen; Novozymes; University of Copenhagen; University of Bristol; University of Copenhagen; Wellcome Trust Sanger Institute; University of California System; University of California Berkeley; University of Copenhagen; University of Bremen
摘要：Major migration events in Holocene Eurasia have been characterized genetically at broad regional scales1-4. However, insights into the population dynamics in the contact zones are hampered by a lack of ancient genomic data sampled at high spatiotemporal resolution5-7. Here, to address this, we analysed shotgun-sequenced genomes from 100 skeletons spanning 7,300 years of the Mesolithic period, Neolithic period and Early Bronze Age in Denmark and integrated these with proxies for diet (13C and 1...
作者：Nakatani, Tsunetoshi; Schauer, Tamas; Altamirano-Pacheco, Luis; Klein, Kyle N.; Ettinger, Andreas; Pal, Mrinmoy; Gilbert, David M.; Torres-Padilla, Maria-Elena
作者单位：State University System of Florida; Florida State University; University of Munich
摘要：DNA replication enables genetic inheritance across the kingdoms of life. Replication occurs with a defined temporal order known as the replication timing (RT) programme, leading to organization of the genome into early- or late-replicating regions. RT is cell-type specific, is tightly linked to the three-dimensional nuclear organization of the genome1,2 and is considered an epigenetic fingerprint3. In spite of its importance in maintaining the epigenome4, the developmental regulation of RT in ...
作者：Yirmiya, Erez; Leavitt, Azita; Lu, Allen; Ragucci, Adelyn E.; Avraham, Carmel; Osterman, Ilya; Garb, Jeremy; Antine, Sadie P.; Mooney, Sarah E.; Hobbs, Samuel J.; Kranzusch, Philip J.; Amitai, Gil; Sorek, Rotem
作者单位：Weizmann Institute of Science; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
摘要：It was recently shown that bacteria use, apart from CRISPR-Cas and restriction systems, a considerable diversity of phage resistance systems1-4, but it is largely unknown how phages cope with this multilayered bacterial immunity. Here we analysed groups of closely related Bacillus phages that showed differential sensitivity to bacterial defence systems, and discovered four distinct families of anti-defence proteins that inhibit the Gabija, Thoeris and Hachiman systems. We show that these prote...
作者：Goodwin, Christopher M.; Lomker, Patrick; Degerman, David; Davies, Bernadette; Shipilin, Mikhail; Garcia-Martinez, Fernando; Koroidov, Sergey; Mathiesen, Jette Katja; Rameshan, Raffael; Rodrigues, Gabriel L. S.; Schlueter, Christoph; Amann, Peter; Nilsson, Anders
作者单位：Stockholm University; Stockholm University; Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); University of Leoben
摘要：The large-scale conversion of N2 and H2 into NH3 (refs. 1,2) over Fe and Ru catalysts3 for fertilizer production occurs through the Haber-Bosch process, which has been considered the most important scientific invention of the twentieth century4. The active component of the catalyst enabling the conversion was variously considered to be the oxide5, nitride2, metallic phase or surface nitride6, and the rate-limiting step has been associated with N2 dissociation7-9, reaction of the adsorbed nitro...
