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作者：Tetter, Stephan; Arseni, Diana; Murzin, Alexey G.; Buhidma, Yazead; Peak-Chew, Sew Y.; Garringer, Holly J.; Newell, Kathy L.; Vidal, Ruben; Apostolova, Liana G.; Lashley, Tammaryn; Ghetti, Bernardino; Ryskeldi-Falcon, Benjamin
作者单位：MRC Laboratory Molecular Biology; University of London; University College London; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; University of London; University College London
摘要：Frontotemporal lobar degeneration (FTLD) causes frontotemporal dementia (FTD), the most common form of dementia after Alzheimer's disease, and is often also associated with motor disorders1. The pathological hallmarks of FTLD are neuronal inclusions of specific, abnormally assembled proteins2. In the majority of cases the inclusions contain amyloid filament assemblies of TAR DNA-binding protein 43 (TDP-43) or tau, with distinct filament structures characterizing different FTLD subtypes3,4. The...
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作者：Gottlieb, Alexander R.; Mankin, Justin S.
作者单位：Dartmouth College; Dartmouth College; Dartmouth College; Columbia University
摘要：Documenting the rate, magnitude and causes of snow loss is essential to benchmark the pace of climate change and to manage the differential water security risks of snowpack declines1-4. So far, however, observational uncertainties in snow mass5,6 have made the detection and attribution of human-forced snow losses elusive, undermining societal preparedness. Here we show that human-caused warming has caused declines in Northern Hemisphere-scale March snowpack over the 1981-2020 period. Using an ...
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作者：Irving-Pease, Evan K.; Refoyo-Martinez, Alba; Barrie, William; Ingason, Andres; Pearson, Alice; Fischer, Anders; Sjoegren, Karl-Goeran; Halgren, Alma S.; Macleod, Ruairidh; Demeter, Fabrice; Henriksen, Rasmus A.; Vimala, Tharsika; Mccoll, Hugh; Vaughn, Andrew H.; Speidel, Leo; Stern, Aaron J.; Scorrano, Gabriele; Ramsoe, Abigail; Schork, Andrew J.; Rosengren, Anders; Zhao, Lei; Kristiansen, Kristian; Iversen, Astrid K. N.; Fugger, Lars; Sudmant, Peter H.; Lawson, Daniel J.; Durbin, Richard; Korneliussen, Thorfinn; Werge, Thomas; Allentoft, Morten E.; Sikora, Martin; Nielsen, Rasmus; Racimo, Fernando; Willerslev, Eske
作者单位：University of Copenhagen; University of Cambridge; University of Copenhagen; Copenhagen University Hospital; University of Cambridge; University of Cambridge; University of Gothenburg; University of California System; University of California Berkeley; University of London; University College London; Centre National de la Recherche Scientifique (CNRS); Museum National d'Histoire Naturelle (MNHN); Universite Paris Cite; University of California System; University of California Berkeley; Francis Crick Institute; Translational Genomics Research Institute; University of Oxford; University of Oxford; Aarhus University; University of Oxford; University of Bristol; Wellcome Trust Sanger Institute; University of Copenhagen; University of Copenhagen; Copenhagen University Hospital; Curtin University; University of California System; University of California Berkeley; University of Bremen; University of Bremen
摘要：The Holocene (beginning around 12,000 years ago) encompassed some of the most significant changes in human evolution, with far-reaching consequences for the dietary, physical and mental health of present-day populations. Using a dataset of more than 1,600 imputed ancient genomes1, we modelled the selection landscape during the transition from hunting and gathering, to farming and pastoralism across West Eurasia. We identify key selection signals related to metabolism, including that selection ...
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作者：[Anonymous]
摘要：Macrophages clear the urine of particles that could clump together to form painful masses.
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作者：Antine, Sadie P.; Johnson, Alex G.; Mooney, Sarah E.; Leavitt, Azita; Mayer, Megan L.; Yirmiya, Erez; Amitai, Gil; Sorek, Rotem; Kranzusch, Philip J.
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Weizmann Institute of Science; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
摘要：Bacteria encode hundreds of diverse defence systems that protect them from viral infection and inhibit phage propagation1-5. Gabija is one of the most prevalent anti-phage defence systems, occurring in more than 15% of all sequenced bacterial and archaeal genomes1,6,7, but the molecular basis of how Gabija defends cells from viral infection remains poorly understood. Here we use X-ray crystallography and cryo-electron microscopy (cryo-EM) to define how Gabija proteins assemble into a supramole...
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作者：Spitz, Josh
作者单位：University of Michigan System; University of Michigan
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作者：Lenharo, Mariana
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作者：Browne, Hilary P.; Iqbal, Najeeha Talat; Osman, Majdi; Tigoi, Caroline; Lawley, Trevor D.; Gordon, Jeffrey I.; Ahmed, Tahmeed; Kariuki, Samuel
作者单位：Wellcome Trust Sanger Institute; Aga Khan University; Aga Khan University; Wellcome Trust Sanger Institute; University of Cambridge; Kenya Medical Research Institute; University of Oxford; Washington University (WUSTL); Saint Louis University; International Centre for Diarrhoeal Disease Research (ICDDR); Kenya Medical Research Institute
摘要：Studies of the microbes living on and in our bodies are conducted mainly in a few rich countries, squandering opportunities to improve the health of people globally.
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作者：Gibson, Margaret
作者单位：Griffith University
摘要：A broad-ranging analysis asks whether we can achieve a kind of immortality by documenting our lives and deaths online.
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作者：Pulliainen, Jouni
作者单位：Finnish Meteorological Institute
摘要：Analysis of a large, varied data set reveals that snow cover in the Northern Hemisphere has undergone marked changes in the past four decades. Evidence that humans caused the shift suggests that snow loss will accelerate in the future.
