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作者：Jin, Hokyung; Yoon, Jin-Hui; Hong, Seon Pyo; Hwang, Yu Seok; Yang, Myung Jin; Choi, Jieun; Kang, Hae Jin; Baek, Seung Eun; Jin, Cheolhwa; Jung, Junho; Kim, Hae Jin; Seo, Jincheol; Won, Jinyoung; Lim, Kyung Seob; Jeon, Chang-Yeop; Lee, Youngjeon; Davis, Michael J.; Park, Hyung-Soon; Mcdonald, Donald M.; Koh, Gou Young
作者单位：Institute for Basic Science - Korea (IBS); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); University of Missouri System; University of Missouri Columbia; Korea Research Institute of Bioscience & Biotechnology (KRIBB); Korea Research Institute of Bioscience & Biotechnology (KRIBB); University of Science & Technology (UST); University of California System; University of California San Francisco; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center
摘要：Cerebrospinal fluid (CSF) in the subarachnoid space around the brain drains to lymph nodes in the neck, but the connections and regulation have been challenging to identify1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23-24. Here we used fluorescent tracers in Prox1-GFP lymphatic reporter mice to map the pathway of CSF outflow through lymphatics to superficial cervical lymph nodes. CSF entered initial lymphatics in the meninges at the skull base and continued t...
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作者：Ramot, Assaf; Taschbach, Felix H.; Yang, Yun C.; Hu, Yuxin; Chen, Qiyu; Morales, Bobbie C.; Wang, Xinyi C.; Wu, An; Tye, Kay M.; Benna, Marcus K.; Komiyama, Takaki
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; Salk Institute; Howard Hughes Medical Institute
摘要：The primary motor cortex (M1) is central for the learning and execution of dexterous motor skills1, 2-3, and its superficial layer (layers 2 and 3; hereafter, L2/3) is a key locus of learning-related plasticity1,4, 5-6. It remains unknown how motor learning shapes the way in which upstream regions activate M1 circuits to execute learned movements. Here, using longitudinal axonal imaging of the main inputs to M1 L2/3 in mice, we show that the motor thalamus is the key input source that encodes ...
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作者：Rivera, Arturo Marroquin; Labonte, Benoit
作者单位：Laval University
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作者：Bhattacharya, Ananyo
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作者：Karhulahti, Veli-Matti
作者单位：University of Jyvaskyla
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作者：Chaves-Perez, Almudena; Millman, Scott E.; Janaki-Raman, Sudha; Ho, Yu-Jui; Hinterleitner, Clemens; Barthet, Valentin J. A.; Morris, John P.; Barriga, Francisco M.; Reyes, Jose; Kyaw, Aye; Pasolli, H. Amalia; Pe'er, Dana; Thompson, Craig B.; Finley, Lydia W. S.; Cross, Justin R.; Lowe, Scott W.
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作者：Zhao, Beibei; Xu, Yuanyuan; Zhu, Qin; Liu, Aokun; Peng, Xichao; Zhang, Tianying; Yu, Lu; Zhang, Yan; Huang, Xiaoqiang
作者单位：Nanjing University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Hefei Institutes of Physical Science, CAS
摘要：Electrochemistry is undergoing a resurgence in synthetic chemistry and has compelling advantages1. Repurposing natural enzymes through synthetic chemical strategies holds promise for exploring new chemical space2, 3, 4, 5-6. Elegant strategies, including directed evolution7, 8, 9-10, artificial enzymes11 and photoenzymatic catalysis12,13, have demonstrated their capacities for expanding the applications of enzymes in both academia and industry. However, the integration of electrochemistry with...
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作者：Pulupa, Joan; McArthur, Natalie G.; Stathi, Olga; Wang, Miao; Zazhytska, Marianna; Pirozzolo, Isabella D.; Nayar, Ahana; Shapiro, Lawrence; Lomvardas, Stavros
作者单位：Columbia University; Columbia University; Columbia University; Columbia University; Columbia University; Columbia University
摘要：Ultra-long-range genomic contacts, which are key components of neuronal genome architecture1, 2-3, constitute a biochemical enigma. This is because regulatory DNA elements make selective and stable contacts with DNA sequences located hundreds of kilobases away, instead of interacting with proximal sequences occupied by the exact same transcription factors1,4. This is exemplified in olfactory sensory neurons (OSNs), in which only a fraction of LHX2-, EBF1- and LDB1-bound sites interact with eac...
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作者：Li, Kai; Ott, Christian; Agaker, Marcus; Ho, Phay J.; Doumy, Gilles; Magunia, Alexander; Rebholz, Marc; Simon, Marc; Mazza, Tommaso; De Fanis, Alberto; Baumann, Thomas M.; Montano, Jacobo; Rennhack, Nils; Usenko, Sergey; Ovcharenko, Yevheniy; Chordiya, Kalyani; Cheng, Lan; Rubensson, Jan-Erik; Meyer, Michael; Pfeifer, Thomas; Gaarde, Mette B.; Young, Linda
作者单位：University of Chicago; United States Department of Energy (DOE); Argonne National Laboratory; Max Planck Society; Uppsala University; Lund University; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); European XFEL; University of Hamburg; Louisiana State University System; Louisiana State University; Johns Hopkins University; University of Chicago
摘要：Propagation of intense X-ray pulses through dense media has led to the observation of phenomena such as atomic X-ray lasing1,2, self-induced transparency3 and stimulated X-ray Raman scattering (SXRS)4. SXRS has been long predicted as a means to launch and probe valence-electron wavepackets and as a building block for nonlinear X-ray spectroscopies5,6. However, experimental observations of SXRS to date4,7,8 have not provided spectroscopic information, and theoretical modelling has largely imple...
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作者：Varghese, Alan; Gusarov, Ivan; Gamallo-Lana, Begona; Dolgonos, Daria; Mankan, Yatin; Shamovsky, Ilya; Phan, Mydia; Jones, Rebecca; Gomez-Jenkins, Maria; White, Eileen; Wang, Rui; Jones, Drew R.; Papagiannakopoulos, Thales; Pacold, Michael E.; Mar, Adam C.; Littman, Dan R.; Nudler, Evgeny
