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作者:You, Xiaoying
摘要:The heat stored in the world's oceans increased by the greatest margin ever in 2023.
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作者:[Anonymous]
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作者:Cho, Min-Guk; Kumar, Rashmi J.; Lin, Chien-Chu; Boyer, Joshua A.; Shahir, Jamshaid A.; Fagan-Solis, Katerina; Simpson, Dennis A.; Fan, Cheng; Foster, Christine E.; Goddard, Anna M.; Lerner, Lynn M.; Ellington, Simon W.; Wang, Qinhong; Wang, Ying; Ho, Alice Y.; Liu, Pengda; Perou, Charles M.; Zhang, Qi; McGinty, Robert K.; Purvis, Jeremy E.; Gupta, Gaorav P.
作者单位:University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill
摘要:Oncogene-induced replication stress generates endogenous DNA damage that activates cGAS-STING-mediated signalling and tumour suppression1-3. However, the precise mechanism of cGAS activation by endogenous DNA damage remains enigmatic, particularly given that high-affinity histone acidic patch (AP) binding constitutively inhibits cGAS by sterically hindering its activation by double-stranded DNA (dsDNA)4-10. Here we report that the DNA double-strand break sensor MRE11 suppresses mammary tumorig...
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作者:Sun, Yuxiang; Dai, Hui; Dai, Xiaoxia; Yin, Jiekai; Cui, Yuxiang; Liu, Xiaochuan; Gonzalez, Gwendolyn; Yuan, Jun; Tang, Feng; Wang, Nan; Perlegos, Alexandra E.; Bonini, Nancy M.; Yang, X. William; Gu, Weifeng; Wang, Yinsheng
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作者:Callaway, Ewen
摘要:An automated laboratory system spent half a year engineering enzymes to work at higher temperatures.
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作者:Fu, Wenyu; Vasylyev, Dmytro; Bi, Yufei; Zhang, Mingshuang; Sun, Guodong; Khleborodova, Asya; Huang, Guiwu; Zhao, Libo; Zhou, Renpeng; Li, Yonggang; Liu, Shujun; Cai, Xianyi; He, Wenjun; Cui, Min; Zhao, Xiangli; Hettinghouse, Aubryanna; Good, Julia; Kim, Ellen; Strauss, Eric; Leucht, Philipp; Schwarzkopf, Ran; Guo, Edward X.; Samuels, Jonathan; Hu, Wenhuo; Attur, Mukundan; Waxman, Stephen G.; Liu, Chuan-ju
作者单位:New York University; Yale University; Yale University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Connecticut Healthcare System; Columbia University; New York University; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; New York University
摘要:Osteoarthritis (OA) is the most common joint disease. Currently there are no effective methods that simultaneously prevent joint degeneration and reduce pain(1). Although limited evidence suggests the existence of voltage-gated sodium channels (VGSCs) in chondrocytes(2), their expression and function in chondrocytes and in OA remain essentially unknown. Here we identify Na(v)1.7 as an OA-associated VGSC and demonstrate that human OA chondrocytes express functional Na(v)1.7 channels, with a den...
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作者:Tamessar, Cottrell
作者单位:University of Newcastle; Hunter Medical Research Institute
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作者:[Anonymous]
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作者:Greene, Chad A.; Gardner, Alex S.; Wood, Michael; Cuzzone, Joshua K.
作者单位:California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); Moss Landing Marine Laboratories; California State University System; San Jose State University; University of California System; University of California Los Angeles
摘要:Nearly every glacier in Greenland has thinned or retreated over the past few decades1-4, leading to glacier acceleration, increased rates of sea-level rise and climate impacts around the globe5-9. To understand how calving-front retreat has affected the ice-mass balance of Greenland, we combine 236,328 manually derived and AI-derived observations of glacier terminus positions collected from 1985 to 2022 and generate a 120-m-resolution mask defining the ice-sheet extent every month for nearly f...
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作者:Gugger, Morgan K.; Hergenrother, Paul J.
作者单位:University of Illinois System; University of Illinois Urbana-Champaign