-
作者：You, Xiaoying
摘要：The heat stored in the world's oceans increased by the greatest margin ever in 2023.
-
作者：[Anonymous]
-
作者：Cho, Min-Guk; Kumar, Rashmi J.; Lin, Chien-Chu; Boyer, Joshua A.; Shahir, Jamshaid A.; Fagan-Solis, Katerina; Simpson, Dennis A.; Fan, Cheng; Foster, Christine E.; Goddard, Anna M.; Lerner, Lynn M.; Ellington, Simon W.; Wang, Qinhong; Wang, Ying; Ho, Alice Y.; Liu, Pengda; Perou, Charles M.; Zhang, Qi; McGinty, Robert K.; Purvis, Jeremy E.; Gupta, Gaorav P.
作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill
摘要：Oncogene-induced replication stress generates endogenous DNA damage that activates cGAS-STING-mediated signalling and tumour suppression1-3. However, the precise mechanism of cGAS activation by endogenous DNA damage remains enigmatic, particularly given that high-affinity histone acidic patch (AP) binding constitutively inhibits cGAS by sterically hindering its activation by double-stranded DNA (dsDNA)4-10. Here we report that the DNA double-strand break sensor MRE11 suppresses mammary tumorig...
-
作者：Sun, Yuxiang; Dai, Hui; Dai, Xiaoxia; Yin, Jiekai; Cui, Yuxiang; Liu, Xiaochuan; Gonzalez, Gwendolyn; Yuan, Jun; Tang, Feng; Wang, Nan; Perlegos, Alexandra E.; Bonini, Nancy M.; Yang, X. William; Gu, Weifeng; Wang, Yinsheng
-
作者：Callaway, Ewen
摘要：An automated laboratory system spent half a year engineering enzymes to work at higher temperatures.
-
作者：Fu, Wenyu; Vasylyev, Dmytro; Bi, Yufei; Zhang, Mingshuang; Sun, Guodong; Khleborodova, Asya; Huang, Guiwu; Zhao, Libo; Zhou, Renpeng; Li, Yonggang; Liu, Shujun; Cai, Xianyi; He, Wenjun; Cui, Min; Zhao, Xiangli; Hettinghouse, Aubryanna; Good, Julia; Kim, Ellen; Strauss, Eric; Leucht, Philipp; Schwarzkopf, Ran; Guo, Edward X.; Samuels, Jonathan; Hu, Wenhuo; Attur, Mukundan; Waxman, Stephen G.; Liu, Chuan-ju
作者单位：New York University; Yale University; Yale University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Connecticut Healthcare System; Columbia University; New York University; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; New York University
摘要：Osteoarthritis (OA) is the most common joint disease. Currently there are no effective methods that simultaneously prevent joint degeneration and reduce pain(1). Although limited evidence suggests the existence of voltage-gated sodium channels (VGSCs) in chondrocytes(2), their expression and function in chondrocytes and in OA remain essentially unknown. Here we identify Na(v)1.7 as an OA-associated VGSC and demonstrate that human OA chondrocytes express functional Na(v)1.7 channels, with a den...
-
作者：Tamessar, Cottrell
作者单位：University of Newcastle; Hunter Medical Research Institute
-
作者：[Anonymous]
-
作者：Greene, Chad A.; Gardner, Alex S.; Wood, Michael; Cuzzone, Joshua K.
作者单位：California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); Moss Landing Marine Laboratories; California State University System; San Jose State University; University of California System; University of California Los Angeles
摘要：Nearly every glacier in Greenland has thinned or retreated over the past few decades1-4, leading to glacier acceleration, increased rates of sea-level rise and climate impacts around the globe5-9. To understand how calving-front retreat has affected the ice-mass balance of Greenland, we combine 236,328 manually derived and AI-derived observations of glacier terminus positions collected from 1985 to 2022 and generate a 120-m-resolution mask defining the ice-sheet extent every month for nearly f...
-
作者：Gugger, Morgan K.; Hergenrother, Paul J.
作者单位：University of Illinois System; University of Illinois Urbana-Champaign
