-
作者:[Anonymous]
摘要:Promises to safeguard biodiversity need to be translated into money in the bank.
-
作者:Dickson, C. F.; Hertel, S.; Tuckwell, A. J.; Li, N.; Ruan, J.; Al-Izzi, S. C.; Ariotti, N.; Sierecki, E.; Gambin, Y.; Morris, R. G.; Towers, G. J.; Bocking, T.; Jacques, D. A.
作者单位:University of New South Wales Sydney; University of New South Wales Sydney; University of New South Wales Sydney; University of New South Wales Sydney; University of Queensland; University of London; University College London
摘要:HIV can infect non-dividing cells because the viral capsid can overcome the selective barrier of the nuclear pore complex and deliver the genome directly into the nucleus1,2. Remarkably, the intact HIV capsid is more than 1,000 times larger than the size limit prescribed by the diffusion barrier of the nuclear pore3. This barrier in the central channel of the nuclear pore is composed of intrinsically disordered nucleoporin domains enriched in phenylalanine-glycine (FG) dipeptides. Through mult...
-
作者:Paolo, Fernando S.; Kroodsma, David; Raynor, Jennifer; Hochberg, Tim; Davis, Pete; Cleary, Jesse; Marsaglia, Luca; Orofino, Sara; Thomas, Christian; Halpin, Patrick
-
作者:Haakonsen, Diane L.; Heider, Michael; Ingersoll, Andrew J.; Vodehnal, Kayla; Witus, Samuel R.; Uenaka, Takeshi; Wernig, Marius; Rape, Michael
作者单位:University of California System; University of California Berkeley; University of California System; University of California Berkeley; Howard Hughes Medical Institute; Stanford University; Stanford University; University of California System; University of California Berkeley
摘要:Stress response pathways detect and alleviate adverse conditions to safeguard cell and tissue homeostasis, yet their prolonged activation induces apoptosis and disrupts organismal health1-3. How stress responses are turned off at the right time and place remains poorly understood. Here we report a ubiquitin-dependent mechanism that silences the cellular response to mitochondrial protein import stress. Crucial to this process is the silencing factor of the integrated stress response (SIFI), a l...
-
作者:Liu, Haimeng; Liu, Jianguo
作者单位:Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS; Michigan State University
-
作者:Vivier, Eric; Rebuffet, Lucas; Narni-Mancinelli, Emilie; Cornen, Stephanie; Igarashi, Rob Y.; Fantin, Valeria R.
作者单位:Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille
摘要:Natural killer (NK) cells are lymphocytes of the innate immune system. A key feature of NK cells is their ability to recognize a wide range of cells in distress, particularly tumour cells and cells infected with viruses. They combine both direct effector functions against their cellular targets and participate in the generation, shaping and maintenance of a multicellular immune response. As our understanding has deepened, several therapeutic strategies focused on NK cells have been conceived a...
-
作者:King, Ross D.; Scassa, Teresa; Kramer, Stefan; Kitano, Hiroaki
作者单位:University of Cambridge; University of Ottawa; Johannes Gutenberg University of Mainz; Okinawa Institute of Science & Technology Graduate University
-
作者:Poppenwimer, Tyler; Mayrose, Itay; DeMalach, Niv
-
作者:Jones, Nicola
摘要:Publishers are deploying AI-based tools to detect suspicious images, but generative AI threatens their efforts.
-
作者:Liu, Haimeng; Liu, Jianguo
作者单位:Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS; Michigan State University
摘要:Letter to the Editor