Natural killer cell therapies

• 成果类型: Review
• 署名作者: Vivier, Eric; Rebuffet, Lucas; Narni-Mancinelli, Emilie; Cornen, Stephanie; Igarashi, Rob Y.; Fantin, Valeria R.
• 署名单位: Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille
• 刊物名称: Nature
• ISSN/ISSBN: 0028-6521
• DOI: 10.1038/s41586-023-06945-1
• 发表日期: 2024-02-22
• 页码: 727-736
• 关键词: innate lymphoid-cells; moloney leukemia-cells; activates nk cells; t-cells; mediated cytotoxicity; in-vitro; antibody; cancer; receptor; cd16

摘要

Natural killer (NK) cells are lymphocytes of the innate immune system. A key feature of NK cells is their ability to recognize a wide range of cells in distress, particularly tumour cells and cells infected with viruses. They combine both direct effector functions against their cellular targets and participate in the generation, shaping and maintenance of a multicellular immune response. As our understanding has deepened, several therapeutic strategies focused on NK cells have been conceived and are currently in various stages of development, from preclinical investigations to clinical trials. Here we explore in detail the complexity of NK cell biology in humans and highlight the role of these cells in cancer immunity. We also analyse the harnessing of NK cell immunity through immune checkpoint inhibitors, NK cell engagers, and infusions of preactivated or genetically modified, autologous or allogeneic NK cell products. This Review explores in detail the complexity of NK cell biology in humans and highlights the role of these cells in cancer immunity.