-
作者：Palffy, Adriana; Lopez-Urrutia, Jose R. Crespo
作者单位：University of Wurzburg; Max Planck Society
-
作者：Chen, Sophia
摘要：In the hills of eastern Tennessee, a record-breaking machine called Frontier is providing scientists with unprecedented opportunities to study everything from atoms to galaxies.
-
作者：Smith, Kerri
-
作者：Smith, Roff
摘要：A survey of the Dolmen of Menga suggests that the stone tomb's Neolithic builders had an understanding of science.
-
作者：Lim, Juhwan; Lee, Jung-In; Wang, Ye; Gauriot, Nicolas; Sebastian, Ebin; Chhowalla, Manish; Schnedermann, Christoph; Rao, Akshay
作者单位：University of Cambridge; University of Cambridge
摘要：Crystallographic phase engineering plays an important part in the precise control of the physical and electronic properties of materials. In two-dimensional transition metal dichalcogenides (2D TMDs), phase engineering using chemical lithiation with the organometallization agent n-butyllithium (n-BuLi), to convert the semiconducting 2H (trigonal) to the metallic 1T (octahedral) phase, has been widely explored for applications in areas such as transistors, catalysis and batteries1-15. Although ...
-
作者：Zhang, Mingkai; Chapman, Matthew; Sarode, Bhagyesh R.; Xiong, Bingcong; Liang, Hao; Chen, James K.; Weerapana, Eranthie; Morken, James P.
作者单位：Boston College; Stanford University; Stanford University; Stanford University
摘要：Although aromatic rings are common elements in pharmaceutically active compounds, the presence of these motifs brings several liabilities with respect to the developability of a drug(1). Nonoptimal potency, metabolic stability, solubility and lipophilicity in pharmaceutical compounds can be improved by replacing aromatic rings with non-aromatic isosteric motifs(2). Moreover, whereas aromatic rings are planar and lack three-dimensionality, the binding pockets of most pharmaceutical targets are ...
-
作者：Collinson, Glyn A.; Glocer, Alex; Pfaff, Robert; Barjatya, Aroh; Conway, Rachel; Breneman, Aaron; Clemmons, James; Eparvier, Francis; Michell, Robert; Mitchell, David; Imber, Suzie; Akbari, Hassanali; Davis, Lance; Kavanagh, Andrew; Robertson, Ellen; Swanson, Diana; Xu, Shaosui; Miller, Jacob; Cameron, Timothy; Chornay, Dennis; Uribe, Paulo; Nguyen, Long; Clayton, Robert; Graves, Nathan; Debchoudhury, Shantanab; Valentine, Henry; Ghalib, Ahmed
作者单位：National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Catholic University of America; Embry-Riddle Aeronautical University; University System Of New Hampshire; University of New Hampshire; University of Colorado System; University of Colorado Boulder; University of California System; University of California Berkeley; University of Leicester; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Antarctic Survey; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Wallops Flight Facility
摘要：Cold plasma of ionospheric origin has recently been found to be a much larger contributor to the magnetosphere of Earth than expected(1-3). Numerous competing mechanisms have been postulated to drive ion escape to space, including heating and acceleration by wave-particle interactions(4) and a global electrostatic field between the ionosphere and space (called the ambipolar or polarization field)(5,6). Observations of heated O+ ions in the magnetosphere are consistent with resonant wave-partic...
-
作者：Polonen, Petri; Di Giacomo, Danika; Seffernick, Anna Eames; Elsayed, Abdelrahman; Kimura, Shunsuke; Benini, Francesca; Montefiori, Lindsey E.; Wood, Brent L.; Xu, Jason; Chen, Changya; Cheng, Zhongshan; Newman, Haley; Myers, Jason; Iacobucci, Ilaria; Li, Elizabeth; Sussman, Jonathan; Hedges, Dale; Hui, Yawei; Diorio, Caroline; Uppuluri, Lahari; Frank, David; Fan, Yiping; Chang, Yunchao; Meshinchi, Soheil; Ries, Rhonda; Shraim, Rawan; Li, Alexander; Bernt, Kathrin M.; Devidas, Meenakshi; Winter, Stuart S.; Dunsmore, Kimberly P.; Inaba, Hiroto; Carroll, William L.; Ramirez, Nilsa C.; Phillips, Aaron H.; Kriwacki, Richard W.; Yang, Jun J.; Vincent, Tiffaney L.; Zhao, Yaqi; Ghate, Pankaj S.; Wang, Jian; Reilly, Colleen; Zhou, Xin; Sanders, Mathijs A.; Takita, Junko; Kato, Motohiro; Takasugi, Nao; Chang, Bill H.; Press, Richard D.; Loh, Mignon; Rampersaud, Evadnie; Raetz, Elizabeth; Hunger, Stephen P.; Tan, Kai; Chang, Ti-Cheng; Wu, Gang; Pounds, Stanley B.; Mullighan, Charles G.; Teachey, David T.
作者单位：St Jude Children's Research Hospital; University of Perugia; St Jude Children's Research Hospital; Sapienza University Rome; IRCCS Bambino Gesu; Children's Hospital Los Angeles; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; St Jude Children's Research Hospital; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Fred Hutchinson Cancer Center; St Jude Children's Research Hospital; Children's Hospitals & Clinics of Minnesota; Children's Hospitals & Clinics of Minnesota; University of Virginia; St Jude Children's Research Hospital; NYU Langone Medical Center; NYU Langone Medical Center; University System of Ohio; Ohio State University; Nationwide Childrens Hospital; St Jude Children's Research Hospital; University of Tennessee System; University of Tennessee Health Science Center; University of Tennessee System; University of Tennessee Health Science Center; St Jude Children's Research Hospital; St Jude Children's Research Hospital; Erasmus University Rotterdam; Erasmus MC; Erasmus MC Cancer Institute; Wellcome Trust Sanger Institute; Kyoto University; University of Tokyo; Oregon Health & Science University; Oregon Health & Science University; Seattle Children's Hospital; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Seattle Children's Hospital; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia
摘要：T-lineage acute lymphoblastic leukaemia (T-ALL) is a high-risk tumour(1) that has eluded comprehensive genomic characterization, which is partly due to the high frequency of noncoding genomic alterations that result in oncogene deregulation(2,3). Here we report an integrated analysis of genome and transcriptome sequencing of tumour and remission samples from more than 1,300 uniformly treated children with T-ALL, coupled with epigenomic and single-cell analyses of malignant and normal T cell pr...
-
作者：Alcon, Pablo; Kaczmarczyk, Artur P.; Ray, Korak Kumar; Liolios, Themistoklis; Guilbaud, Guillaume; Sijacki, Tamara; Shen, Yichao; McLaughlin, Stephen H.; Sale, Julian E.; Knipscheer, Puck; Rueda, David S.; Passmore, Lori A.
作者单位：MRC Laboratory Molecular Biology; Imperial College London; Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW); Utrecht University; Utrecht University Medical Center
摘要：DNA crosslinks block DNA replication and are repaired by the Fanconi anaemia pathway. The FANCD2-FANCI (D2-I) protein complex is central to this process as it initiates repair by coordinating DNA incisions around the lesion(1). However, D2-I is also known to have a more general role in DNA repair and in protecting stalled replication forks from unscheduled degradation(2-4). At present, it is unclear how DNA crosslinks are recognized and how D2-I functions in replication fork protection. Here, ...
-
作者：Gibney, Elizabeth
