作者：Recaldin, Timothy; Steinacher, Linda; Gjeta, Bruno; Harter, Marius F.; Adam, Lukas; Kromer, Kristina; Mendes, Marisa Pimentel; Bellavista, Marina; Nikolaev, Mikhail; Lazzaroni, Giacomo; Krese, Rok; Kilik, Umut; Popovic, Doris; Stoll, Bilgenaz; Gerard, Regine; Bscheider, Michael; Bickle, Marc; Cabon, Lauriane; Camp, J. Gray; Gjorevski, Nikolche
作者单位：Roche Holding; Hannover Medical School; University of Basel; Universite Paris Saclay
摘要：The intimate relationship between the epithelium and immune system is crucial for maintaining tissue homeostasis, with perturbations therein linked to autoimmune disease and cancer1-3. Whereas stem cell-derived organoids are powerful models of epithelial function4, they lack tissue-resident immune cells that are essential for capturing organ-level processes. We describe human intestinal immuno-organoids (IIOs), formed through self-organization of epithelial organoids and autologous tissue-resi...
作者：Arias, Andres A.; Neehus, Anna-Lena; Ogishi, Masato; Meynier, Vincent; Krebs, Adam; Lazarov, Tomi; Lee, Angela M.; Arango-Franco, Carlos A.; Yang, Rui; Orrego, Julio; Corcini Berndt, Melissa; Rojas, Julian; Li, Hailun; Rinchai, Darawan; Erazo-Borras, Lucia; Han, Ji Eun; Pillay, Bethany; Ponsin, Khoren; Chaldebas, Matthieu; Philippot, Quentin; Bohlen, Jonathan; Rosain, Jeremie; Le Voyer, Tom; Janotte, Till; Amarajeeva, Krishnajina; Soudee, Camille; Brollo, Marion; Wiegmann, Katja; Marquant, Quentin; Seeleuthner, Yoann; Lee, Danyel; Laine, Candice; Kloos, Doreen; Bailey, Rasheed; Bastard, Paul; Keating, Narelle; Rapaport, Franck; Khan, Taushif; Moncada-Velez, Marcela; Camila Carmona, Maria; Obando, Catalina; Alvarez, Jesus; Carlos Catano, Juan; Martinez-Rosado, Larry Luber; Sanchez, Juan P.; Tejada-Giraldo, Manuela; L'Honneur, Anne-Sophie; Agudelo, Maria L.; Perez-Zapata, Lizet J.; Arboleda, Diana M.; Fernando Alzate, Juan; Cabarcas, Felipe; Zuluaga, Alejandra; Pelham, Simon J.; Ensser, Armin; Schmidt, Monika; Velasquez-Lopera, Margarita M.; Jouanguy, Emmanuelle; Puel, Anne; Kronke, Martin; Ghirardello, Stefano; Borghesi, Alessandro; Pahari, Susanta; Boisson, Bertrand; Pittaluga, Stefania; Ma, Cindy S.; Emile, Jean-Francois; Notarangelo, Luigi D.; Tangye, Stuart G.; Marr, Nico; Lachmann, Nico; Salvator, Helene; Schlesinger, Larry S.; Zhang, Peng; Glickman, Michael S.; Nathan, Carl F.; Geissmann, Frederic; Abel, Laurent; Luis Franco, Jose; Bustamante, Jacinta; Casanova, Jean-Laurent; Boisson-Dupuis, Stephanie
作者单位：Universidad de Antioquia; Universidad de Antioquia; Rockefeller University; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Garvan Institute of Medical Research; University of New South Wales Sydney; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; INRAE; Universite Paris Saclay; University of Cologne; University of Cologne; Hannover Medical School; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Walter & Eliza Hall Institute; University of Melbourne; Jackson Laboratory; Universidad de Antioquia; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Cochin - APHP; Universidad de Antioquia; Universidad de Antioquia; University of Erlangen Nuremberg; Universidad de Antioquia; University of Cologne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss School of Public Health (SSPH+); Texas Biomedical Research Institute; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Ambroise-Pare - APHP; National Institutes of Health (NIH) - USA; Division of Intramural Research (DIR); NIH National Institute of Allergy & Infectious Diseases (NIAID); Sidra Medical & Research Center; Qatar Foundation (QF); Hamad Bin Khalifa University-Qatar; Hannover Medical School; Hospital Foch; Universite Paris Saclay; Howard Hughes Medical Institute; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP
摘要：Severe defects in human IFN gamma immunity predispose individuals to both Bacillus Calmette-Guerin disease and tuberculosis, whereas milder defects predispose only to tuberculosis(1). Here we report two adults with recurrent pulmonary tuberculosis who are homozygous for a private loss-of-function TNF variant. Neither has any other clinical phenotype and both mount normal clinical and biological inflammatory responses. Their leukocytes, including monocytes and monocyte-derived macrophages (MDMs...
作者：Smith, Martin R.; Long, Emma J.; Dhungana, Alavya; Dobson, Katherine J.; Yang, Jie; Zhang, Xiguang
作者单位：Durham University; Natural History Museum London; University of Exeter; University of Strathclyde; University of Strathclyde; Yunnan University
摘要：The Cambrian radiation of euarthropods can be attributed to an adaptable body plan. Sophisticated brains and specialized feeding appendages, which are elaborations of serially repeated organ systems and jointed appendages, underpin the dominance of Euarthropoda in a broad suite of ecological settings. The origin of the euarthropod body plan from a grade of vermiform taxa with hydrostatic lobopodous appendages ('lobopodian worms')(1,2) is founded on data from Burgess Shale-type fossils. However...
