8090期

最新文章

• Tracking clonal evolution during treatment in ovarian cancer using cell-free DNA AI翻译
  作者：Williams, Marc J.; Vazquez-Garcia, Ignacio; Tam, Grittney; Wu, Michelle; Varice, Nancy; Havasov, Eliyahu; Shi, Hongyu; Al-Rawi, Duaa H.; Satas, Gryte; Lees, Hannah J.; Lee, Jake June-Koo; Myers, Matthew A.; Zatzman, Matthew; Rusk, Nicole; Ali, Emily; Shah, Ronak H.; Berger, Michael F.; Mohibullah, Neeman; Lakhman, Yulia; Chi, Dennis S.; Abu-Rustum, Nadeem R.; Aghajanian, Carol; Mcpherson, Andrew; Zamarin, Dmitriy; Loomis, Brian; Weigelt, Britta; Friedman, Claire F.; Shah, Sohrab P.
  作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Columbia University; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Icahn School of Medicine at Mount Sinai; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：Emergence of drug resistance is the main cause of therapeutic failure in patients with high-grade serous ovarian cancer (HGSOC)1. To study drug resistance in patients, we developed CloneSeq-SV, which combines single-cell whole-genome sequencing2 with targeted deep sequencing of clone-specific genomic structural variants in time-series cell-free DNA. CloneSeq-SV exploits tumour clone-specific structural variants as highly sensitive endogenous cell-free DNA markers, enabling the relative abundan...
• The apple of my eye: How I've created a plant-health tracker for farmers in Tanzania AI翻译
  作者：Cebola, Tavares
• China's new scientist visa is a 'serious bid' for the world's top talent AI翻译
  作者：You, Xiaoying
• Bill Gates's climate comments are a dangerous distraction AI翻译
  作者：Mann, Michael E.
  作者单位：University of Pennsylvania
• Synthesis of enantioenriched atropisomers by biocatalytic deracemization AI翻译
  作者：Roos, Casey B.; Schulert, S. Luke; Zetzsche, Lara E.; McMinn, Spencer E.; Cheong, Angela E.; Shim, Eunjae; Kwan, Eugene E.; Narayan, Alison R. H.
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Merck & Company; Merck & Company USA; University of Michigan System; University of Michigan
  摘要：The synthesis of enantiopure materials is vital for pharmaceutical and agrochemical industries owing to the inherently chiral nature of biological systems and the fact that two enantiomers can have markedly different biochemical properties1. In particular, enantioselective preparation of atropisomers is of great interest owing to their privileged status as chiral ligands and pharmacophores2, 3-4. Although chromatographic- or crystallization-based methods are commonly used to separate atropisom...
• Radio burst from a stellar coronal mass ejection AI翻译
  作者：Callingham, J. R.; Tasse, C.; Keers, R.; Kavanagh, R. D.; Vedantham, H. K.; Zarka, P.; Bellotti, S.; Cristofari, P. I.; Bloot, S.; Konijn, D. C.; Hardcastle, M. J.; Lamy, L.; Pass, E. K.; Pope, B. J. S.; Reid, H.; Rottgering, H. J. A.; Shimwell, T. W.; Zucca, P.
  作者单位：University of Amsterdam; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Observatoire de Paris; Rhodes University; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Universite de Orleans; Observatoire de Paris; Max Planck Society; Braunschweig University of Technology; University of Groningen; Kapteyn Astronomical Institute; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Sorbonne Universite; Universite Paris Cite; Leiden University; Leiden University - Excl LUMC; Centre National de la Recherche Scientifique (CNRS); Communaute d'universites et etablissements de Toulouse (Comue); Universite de Toulouse (EPE); Smithsonian Institution; University of Hertfordshire; Centre National d'Etudes Spatiales (CNES); Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; Massachusetts Institute of Technology (MIT); Macquarie University; University of London; University College London
  摘要：Coronal mass ejections (CMEs) are massive expulsions of magnetized plasma from a star and are the largest contributors to space weather in the Solar System1,2. CMEs play an important role in planetary atmospheric erosion, especially for planets that are close to their host star3, 4-5. However, this conclusion remains controversial as there has not been an unambiguous detection of a CME from a star outside our Sun. Previous stellar CME studies have only inferred the presence of a CME through th...
• Rewiring Democracy: How AI Will Transform Our Politics, Government, and Citizenship AI翻译
  作者：Eubanks, Virginia
  作者单位：State University of New York (SUNY) System; University at Albany, SUNY
• Fair Doses: An Insiders Story of the Pandemic and the Global Fight for Vaccine Equity AI翻译
  作者：Hausdorff, William P.
• Want a younger brain? Learn another language AI翻译
  作者：Kavanagh, Katie
• The complex tale of snake and lizard evolution AI翻译
  作者：Zaher, Hussam
  作者单位：Universidade de Sao Paulo