8094期

最新文章

• Solar cells that combine multiple perovskite layers surpass 30% efficiency AI翻译
  作者：Hu, Shuaifeng; Snaith, Henry J.
  作者单位：University of Oxford
• A probabilistic histological atlas of the human brain for MRI segmentation AI翻译
  作者：Casamitjana, Adria; Mancini, Matteo; Robinson, Eleanor; Peter, Loic; Annunziata, Roberto; Althonayan, Juri; Crampsie, Shauna; Blackburn, Emily; Billot, Benjamin; Atzeni, Alessia; Puonti, Oula; Balbastre, Yael; Schmidt, Peter; Hughes, James; Augustinack, Jean C.; Edlow, Brian L.; Zollei, Lilla; Thomas, David L.; Kliemann, Dorit; Bocchetta, Martina; Strand, Catherine; Holton, Janice L.; Jaunmuktane, Zane; Iglesias, Juan Eugenio
  作者单位：University of London; University College London; Universitat de Girona; Cardiff University; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; University of London; University College London; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of London; University College London; University of London; University College London; University of Iowa; University of Iowa; Brunel University; University of London; University College London
  摘要：In human neuroimaging, brain atlases are essential for segmenting regions of interest (ROIs) and comparing subjects in a common coordinate frame. State-of-the-art atlases derived from histology1, 2-3 provide exquisite three-dimensional cytoarchitectural maps but lack probabilistic labels throughout the whole brain: that is, the likelihood of each location belonging to a given ROI. Here we present NextBrain, a probabilistic histological atlas of the whole human brain. We developed artificial in...
• Structural snapshots capture nucleotide release at the μ-opioid receptor AI翻译
  作者：Khan, Saif; Tyson, Aaliyah S.; Ranjbar, Mohsen; Zhang, Zixin; Singh, Jaskaran; Han, Gye Won; Gati, Cornelius
  作者单位：University of Southern California; University of Southern California; University of Southern California; University of Southern California
  摘要：As a member of the G protein-coupled receptor superfamily, the mu-opioid receptor (MOR) activates heterotrimeric G proteins by opening the G alpha alpha-helical domain (AHD) to enable GDP-GTP exchange, with GDP release representing the rate-limiting step1,2. Here, using pharmacological assays, we show that agonist efficacy correlates with decreased GDP affinity, promoting GTP exchange, whereas antagonists increase GDP affinity, dampening activation. Further investigating this phenomenon, we pr...
• Helicase-mediated mechanism of SSU processome maturation and disassembly AI翻译
  作者：Buzovetsky, Olga; Klinge, Sebastian
  作者单位：Rockefeller University
  摘要：Eukaryotic ribosomal small subunit (SSU) assembly requires the SSU processome, a nucleolar precursor containing the RNA chaperone U3 small nucleolar RNA (snoRNA). The underlying molecular mechanisms of SSU processome maturation, remodelling, disassembly and RNA quality control, and the transitions between states remain unknown owing to a paucity of intermediates1, 2-3. Here we report 16 native SSU processome structures alongside genetic data, revealing how two helicases, the Mtr4-exosome and D...
• The first-principles phase diagram of monolayer nanoconfined water (Vol 609, pg 512, 2022) AI翻译
  作者：Kapil, Venkat; Schran, Christoph; Zen, Andrea; Chen, Ji; Pickard, Chris J.; Michaelides, Angelos
• Evidence for improved DNA repair in the long-lived bowhead whale (OCT, 10.1038/s41586-025-09694-5, 2025) AI翻译
  作者：Firsanov, Denis; Zacher, Max; Tian, Xiao; Sformo, Todd L.; Zhao, Yang; Tombline, Gregory; Lu, J. Yuyang; Zheng, Zhizhong; Perelli, Luigi; Gurreri, Enrico; Zhang, Li; Guo, Jing; Korotkov, Anatoly; Volobaev, Valentin; Biashad, Seyed Ali; Zhang, Zhihui; Heid, Johanna; Maslov, Alexander Y.; Sun, Shixiang; Wu, Zhuoer; Gigas, Jonathan; Hillpot, Eric C.; Martinez, John C.; Lee, Minseon; Williams, Alyssa; Gilman, Abbey; Hamilton, Nicholas; Strelkova, Ekaterina; Haseljic, Ena; Patel, Avnee; Straight, Maggie E.; Miller, Nalani; Ablaeva, Julia; Tam, Lok Ming; Couderc, Chloe; Hoopmann, Michael R.; Moritz, Robert L.; Fujii, Shingo; Pelletier, Amandine; Hayman, Dan J.; Liu, Hongrui; Cai, Yuxuan; Leung, Anthony K. L.; Zhang, Zhengdong; Nelson, C. Bradley; Abegglen, Lisa M.; Schiffman, Joshua D.; Gladyshev, Vadim N.; Maley, Carlo C.; Modesti, Mauro; Genovese, Giannicola; Simons, Mirre J. P.; Vijg, Jan; Seluanov, Andrei; Gorbunova, Vera
• AI is transforming the economy - understanding its impact requires both data and imagination AI翻译
  作者：Bjorkegren, Daniel
  作者单位：Columbia University
• The Coming Wave AI翻译
  作者：Ibrahim, Mohamed
• This scientist found a new trick of the immune system by digging through cellular rubbish AI翻译
  作者：Willyard, Cassandra
• Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis (vol 574, pg 428, 2019) AI翻译
  作者：Newton, Kim; Wickliffe, Katherine E.; Dugger, Debra L.; Maltzman, Allie; Roose-Girma, Merone; Dohse, Monika; Komuves, Laszlo; Webster, Joshua D.; Dixit, Vishva M.