8094期

最新文章

• Clues about mysterious prehistoric city in China AI翻译
  作者：Dong, Yu; Malhi, Ripan S.
  作者单位：Shandong University; University of Illinois System; University of Illinois Urbana-Champaign
• Neoadjuvant immunotherapy in mismatch-repair-proficient colon cancers AI翻译
  作者：Tan, Pedro B.; Verschoor, Yara L.; van den Berg, Jose G.; Balduzzi, Sara; Kok, Niels F. M.; Ijsselsteijn, Marieke E.; Moore, Kat; Jurdi, Adham; Tin, Antony; Kaptein, Paulien; van Leerdam, Monique E.; Haanen, John B. A. G.; Voest, Emile E.; de Miranda, Noel F. C. C.; Schumacher, Ton N.; Wessels, Lodewyk F. A.; Chalabi, Myriam
  作者单位：Netherlands Cancer Institute; Netherlands Cancer Institute; Netherlands Cancer Institute; Netherlands Cancer Institute; Leiden University; Leiden University - Excl LUMC; Leiden University Medical Center (LUMC); Netherlands Cancer Institute; Natera, Inc.; Netherlands Cancer Institute; Leiden University; Leiden University - Excl LUMC; Leiden University Medical Center (LUMC); Netherlands Cancer Institute; Leiden University; Leiden University - Excl LUMC; Leiden University Medical Center (LUMC)
  摘要：Immune checkpoint blockade has led to paradigm shifts in the treatment of various tumour types1, 2, 3-4, yet limited efficacy has been observed in patients with metastatic mismatch-repair-proficient (pMMR) colorectal cancer5. Here we report clinical results and in-depth analysis of patients with early-stage pMMR colon cancer from the phase II NICHE study (ClinicalTrials.gov: NCT03026140). A total of 31 patients received neoadjuvant treatment of nivolumab plus ipilimumab followed by surgery. Th...
• The baby whose life was saved by the first personalized CRISPR therapy AI翻译
  作者：Ledford, Heidi
• This scientist is breeding billions of mosquitoes to fight disease in Brazil AI翻译
  作者：Lenharo, Mariana
• Anti-progestin therapy targets hallmarks of breast cancer risk AI翻译
  作者：Simoes, Bruno M.; Pedley, Robert; McCloskey, Curtis W.; Roberts, Matthew; Reed, Austin D.; Twigger, Alecia-Jane; Tharmapalan, Pirashaanthy; Caruso, Amanda; Cabral, Sara; Wilby, Anthony J.; Harrison, Hannah; Zhou, Yuxi; Greenhalgh, Alice; Alghamdi, Suad A.; Forestiero, Martina; Lopez-Munoz, Jesica; Roche, Jasmin; Tuieng, Ren Jie; Khan, Muhammad A.; Squires, Steven; Astley, Susan M.; Harkness, Elaine F.; Santiago-Gomez, Angelica; Spence, Katherine; Ritchie, Jessica; Pritchard, Susan; Lim, Yit; Sherratt, Michael J.; Ando, Sebastiano; Howell, Anthony; Evans, D. Gareth; Gilmore, Andrew P.; Khaled, Walid T.; Khokha, Rama; Clarke, Robert B.; Howell, Sacha J.
  作者单位：University of Manchester; University of Manchester; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Cambridge; University of Calabria; University of Manchester; University of Manchester; Manchester University NHS Foundation Trust; Wythenshawe Hospital NHS Foundation Trust; Wythenshawe Hospital; University of Manchester; University of Manchester; Christie NHS Foundation Trust
  摘要：Breast cancer is the leading cause of cancer-related death in women worldwide1. Here, in the Breast Cancer-Anti-Progestin Prevention Study 1 (BC-APPS1; NCT02408770), we assessed whether progesterone receptor antagonism with ulipristal acetate for 12 weeks reduces surrogate markers of breast cancer risk in 24 premenopausal women. We used multilayered OMICs and live-cell approaches as readouts for molecular features alongside clinical imaging and tissue micromechanics correlates. Ulipristal acet...
• Why Brains Need Friends AI翻译
  作者：Allen, Kelly-Ann
  作者单位：Monash University
• Experiments reveal extreme water generation during planet formation AI翻译
  作者：Miozzi, F.; Shahar, A.; Young, E. D.; Wang, J.; Steele, A.; Borensztajn, S.; Vitale, S. M.; Bullock, E. S.; Wehr, N.; Badro, J.
  作者单位：Carnegie Institution for Science; University of California System; University of California Los Angeles; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; University of Pavia
  摘要：The most abundant type of planet discovered in the Galaxy has no analogue in our Solar System and is believed to consist of a rocky interior with an overlying thick H2-dominated envelope. Models have predicted that the reaction between the atmospheric hydrogen and the underlying magma ocean can lead to the production of notable amounts of water. However, the models suffer from the current lack of experimental data on the reaction between hydrogen and silicate melt at high pressures and tempera...
• These Letters End in Tears AI翻译
  作者：Alang, Sirry
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
• How my institution strengthened research despite chronic underfunding AI翻译
  作者：Shanker, Anil
  作者单位：Meharry Medical College
• Video-rate tunable colour electronic paper with human resolution (vol 646, pg 1089, 2025) AI翻译
  作者：Santosa, Ade Satria Saloka; Chang, Yu-Wei; Dahlin, Andreas B.; Osterlund, Lars; Volpe, Giovanni; Xiong, Kunli