作者：Ahn, Chiyoung; Gomez, Alexander; Hartmann, Marc A.; White, M. Christina
作者单位：University of Illinois System; University of Illinois Urbana-Champaign
摘要：alpha,beta-Unsaturated carbonyl groups-which feature conjugated C=C and C=O bonds-are common in bioactive compounds. Late-stage functionalization of these compounds could involve oxidation of methylene (2 degrees) C-H bonds while leaving the C=C double bonds that are important for biological activity intact1, 2-3. Although catalytic systems have been developed for selective oxidation of methylenes in the presence of aromatics4 and N-heterocycles5, olefins remain a long-standing challenge. Here...
作者：Bi, Huixing; Sun, Daoyuan; Sun, Ningyu; Mao, Zhu; Dai, Mingwei; Hemingway, Douglas
作者：Kato, Nobutaka; Comer, Eamon; Sakata-Kato, Tomoyo; Sharma, Arvind; Sharma, Manmohan; Maetani, Micah; Bastien, Jessica; Brancucci, Nicolas M.; Bittker, Joshua A.; Corey, Victoria; Clarke, David; Derbyshire, Emily R.; Dornan, Gillian L.; Duffy, Sandra; Eckley, Sean; Itoe, Maurice A.; Koolen, Karin M. J.; Lewis, Timothy A.; Lui, Ping S.; Lukens, Amanda K.; Lund, Emily; March, Sandra; Meibalan, Elamaran; Meier, Bennett C.; McPhail, Jacob A.; Mitasev, Branko; Moss, Eli L.; Sayes, Morgane; Van Gessel, Yvonne; Wawer, Mathias J.; Yoshinaga, Takashi; Zeeman, Anne-Marie; Avery, Vicky M.; Bhatia, Sangeeta N.; Burke, John E.; Catteruccia, Flaminia; Clardy, Jon C.; Clemons, Paul A.; Dechering, Koen J.; Duvall, Jeremy R.; Foley, Michael A.; Gusovsky, Fabian; Kocken, Clemens H. M.; Marti, Matthias; Morningstar, Marshall L.; Munoz, Benito; Neafsey, Daniel E.; Sharma, Amit; Winzeler, Elizabeth A.; Wirth, Dyann F.; Scherer, Christina A.; Schreiber, Stuart L.
作者：Michaels, Jonathan A.; Kashefi, Mehrdad; Zheng, Jack; Codol, Olivier; Weiler, Jeffrey; Kersten, Rhonda; Lau, Jonathan C.; Gribble, Paul L.; Diedrichsen, Jorn; Pruszynski, J. Andrew
作者单位：Western University (University of Western Ontario); Western University (University of Western Ontario); York University - Canada; London Health Sciences Centre; Western University (University of Western Ontario); Western University (University of Western Ontario); Western University (University of Western Ontario); Western University (University of Western Ontario)
摘要：The neural basis of movement preparation has been extensively studied during self-initiated actions, in which motor cortical activity during preparation shows a lawful relationship to the parameters of the subsequent action1,2. However, movements are regularly triggered or corrected on the basis of sensory inputs caused by disturbances to the body. Since such disturbances are often predictable, and since preparing for disturbances would make movements more prescise, we hypothesized that expect...
