-
作者：Ledford, Heidi
-
作者：Pazos, Sebastian; Fontana, Andres; Shen, Yaqing; Yuan, Yue; Yu, Yiyang; Shamim, Atif; Psychogiou, Dimitra; Lanza, Mario
作者单位：National University of Singapore; University College Cork; King Abdullah University of Science & Technology; King Abdullah University of Science & Technology; University College Cork; National University of Singapore; Institute for Functional Intelligent Materials (I-FIM); Carnegie Mellon University; Chongqing University
摘要：Monolithic microwave integrated circuits (MMICs) are an emerging technology that is expected to substantially improve telecommunications in the next few years1,2. MMICs use application-specific semiconductors to meet the performance needs of 5G standards and beyond; however, integrating high-frequency switches into these platforms is very demanding in terms of area and cost and doing so is also a bottleneck for performance3. Memristive radio-frequency switches are an appealing alternative due ...
-
作者：Huang, Yongcai; Zhu, Yidong; Cui, Yahui; Shi, Guolong; Wu, Xiaoxian; Li, Wenhao; Chen, Zhiteng; Zhou, Yu; Gu, Yincong; Bao, Zhigui; Luo, Shiqi; Wu, Xingguo; Li, Ruifan; Liu, Jingjing; Dai, Xiangjie; Liu, Junxin; Chen, Di; Gao, Lulu; You, Chong; Li, Youliang; Zhang, Yu; Wang, Wenqin; Wang, Haihai; Wu, Yongrui
作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Sichuan Agricultural University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Normal University
摘要：During maize (Zea mays L.) domestication, seed protein content sharply declined1,2. In plants, glutamine and asparagine levels are closely correlated with protein content3,4. Asparagine is synthesized from glutamine, a process catalysed by asparagine synthase5. Teosinte harbours a superior haplotype of asparagine synthase 4 (ASN4)2. Here, we report that teosinte also possesses a superior haplotype gene promoting glutamine synthesis. We identify and clone teosinte high protein 3 (THP3), which e...
-
作者：Ying, Rui; Monteiro, Fanny M.; Witts, James D.; Schmidt, Daniela N.
作者单位：University of Bristol; University of East Anglia; University of Bristol; UiT The Arctic University of Tromso; Natural History Museum London
摘要：The Chicxulub asteroid impact at the Cretaceous-Paleogene (K-Pg) boundary (66 Ma) is thought to have caused the extinction of around 75% of species in the fossil record by triggering catastrophic environmental changes1. However, despite decades of research, the mechanisms linking the environmental changes to the selective extinction patterns observed in the marine fossil record remain unresolved. Here we use a global trait-based ecosystem model2,3 to establish this causality for the marine pla...
-
作者：Chakrabarty, Ram P.; Van Vranken, Jonathan G.; Aoi, Yuki; Poor, Taylor A.; McElroy, Gregory S.; Vasan, Karthik; Soliman, Shimaa H. A.; Iwanaszko, Marta; Grant, Rogan A.; Howard, Benjamin C.; Reczek, Colleen R.; Chandel, Anjali D.; Kahl, Michael; Xu, Zhaofa; Helmin, Kathryn A.; Jin, Qiushi; Wang, Dongmei; Gao, Peng; Blum, Jenna L. E.; Sebo, Zachary L.; Yue, Feng; Ma, Yongchao C.; Davidson, Shawn M.; Gygi, Steven P.; Weinberg, Samuel E.; Singer, Benjamin D.; Han, SeungHye; Shilatifard, Ali; Chandel, Navdeep S.
作者单位：Northwestern University; Feinberg School of Medicine; Harvard University; Harvard Medical School; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Ann & Robert H. Lurie Children's Hospital of Chicago; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; University of California System; University of California San Francisco
摘要：l-2-Hydroxyglutarate (l-2-HG) is a low-abundance metabolite in mammals because the mitochondrial enzyme l-2-HG dehydrogenase (L2HGDH) oxidizes l-2-HG to 2-oxoglutarate (2-OG) to prevent its accumulation(1). In humans, a lack of L2HGDH activity leads to l-2-HG accumulation and causes l-2-hydroxyglutaric aciduria(2). Thus, l-2-HG is often classified as a toxic metabolite(2, 3, 4-5). However, whether l-2-HG has any physiological function is unclear. Here we investigate whether l-2-HG qualifies as...
-
作者：Pichon, Anne
-
作者：Styfhals, Ruth; Burkhardt, Pawel
作者单位：University of Bergen
-
作者：Johnson, Kevin C.; Spitzer, Avishay; Varn, Frederick S.; Nomura, Masashi; Garofano, Luciano; Chowdhury, Tamrin; Lipsa, Anuja; Zhang, Linbin; Fernandez, Ester Calvo; Barak, Tanyeri; Gulhan Ercan-Sencicek, A.; Peksen, Ayse Buket; Anderson, Kevin J.; Tesileanu, C. Mircea S.; Amin, Samirkumar B.; Kocakavuk, Emre; Zhao, Dacheng; D'Angelo, Fulvio; Migliozzi, Simona; Bussema, Lillian; Gritsch, Simon; Moon, Hyo-Eun; Paek, Sun Ha; Bielle, Franck; Laurenge, Alice; Di Stefano, Anna Luisa; Mathon, Bertrand; Picca, Alberto; Sanson, Marc; Hau, Ann-Christin; Hertel, Frank; Grzyb, Kamil; Zhao, Zheng; Wang, Qianghu; Jiang, Tao; Miller, Julie J.; Wakimoto, Hiroaki; Cahill, Daniel P.; Moliterno, Jennifer; Gunel, Murat; Hermes, Beth; Sanai, Nader; Golebiewska, Anna; Niclou, Simone P.; Huse, Jason; Alfred Yung, W. K.; Lasorella, Anna; Suva, Mario L.; Iavarone, Antonio; Tirosh, Itay; Verhaak, Roel G. W.
作者单位：Yale University; Weizmann Institute of Science; Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky Medical Center; Jackson Laboratory; University of Connecticut; University of Connecticut; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Tokyo; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Miami; University of Miami; Luxembourg Institute of Health; University of Duisburg Essen; University of Miami; University of Miami; Seoul National University (SNU); Seoul National University (SNU); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; Hospital Foch; Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; Beijing Neurosurgical Institute; Capital Medical University; Nanjing Medical University; Nanjing Medical University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; St. Joseph's Hospital and Medical Center; Barrow Neurological Institute; Barrow Neurological Institute; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Amsterdam; Translational Genomics Research Institute
摘要：Gliomas with mutant isocitrate dehydrogenase (IDH) are malignant brain tumours that typically arise in early to mid-adulthood and nearly always recur following treatment1,2. However, the genetic and cellular-state changes that drive IDH-mutant glioma progression under treatment remain incompletely understood. Here we integrated single-nucleus transcriptomic profiles, chromatin accessibility profiles and bulk DNA and RNA sequencing from 75 temporally separated gliomas across 35 patients compris...
-
作者：Xiao, Ke; Sun, Hongfei; Kong, Xinke; Gao, Han; Lou, Jing; Chen, Xingze; Hu, Zimo; Xu, Dongdong; Lin, Renxing; Liu, Runnan; Xia, Siyu; Xie, Jin; Liu, Ye; Luo, Xin; Fan, Fengjia; Ma, Changqi; Chang, Chao; Wang, Yuanyuan; Tan, Hairen
作者单位：Nanjing University; Nanjing University; Nanjing University; Chinese Academy of Sciences; Suzhou Institute of Nano-Tech & Nano-Bionics, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Nanjing University; Nanjing University
摘要：The commercialization of all-perovskite tandem solar modules is hindered by the reliance on the conventional gold-based tunnel recombination junction1,2. Specifically, this tunnel recombination junction introduces substantial near-infrared parasitic absorption3 and suffers from interfacial instability4, limiting both photocurrent generation and operational durability. Here, we develop a solution-processed interconnecting layer based on surface-engineered indium oxide nanocrystals featuring hig...
-
作者：Fan, Shijun; Gao, Peng; Huang, Kailai; Ying, Wei; Xu, Lei; Chen, Weilan; Ye, Huan; Xi, Yi; Yang, Yan; Qian, Hang; Li, Ting; Tu, Bin; Yuan, Hua; Ma, Bingtian; Wang, Yuping; Zhong, Zhaohui; Xiong, Jiawei; Wang, Hao; Kang, Liangzhu; Tang, Shiwen; Chen, Xuewei; Sun, Linfeng; Xiang, Chengbin; Li, Shigui; Qin, Peng
作者单位：Sichuan Agricultural University; Chinese Academy of Sciences; University of Science & Technology of China, CAS
摘要：Cells must rapidly counteract heat stress-induced hyperfluidization of the plasma membrane to prevent membrane damage1,2, yet how cells achieve such early protection remains unknown. Here we show that in rice (Oryza sativa), the P4-ATPase OsALA5, together with its beta-subunit OsALIS2, mediates a heat-responsive flipping of saturated phosphatidylcholines that rapidly stabilizes plasma membrane fluidity. Using leaflet-resolved lipidomics and complementary transport assays, we demonstrate that h...
