作者：Simonet, Nicolas G.; Thackray, Joshua K.; Kesner, Barry; Guitart-Solanes, Anna; Serra, Francois; Espinosa-Alcantud, Maria; Lappala, Anna; Marin-Gual, Laia; Marin-Garcia, Cristina; Weissbein, Uri; Castello-Garcia, Josema; Bauer, Moritz; Wang, Danni; Rovirosa, Llorenc; Tischfield, Jay; Serrano, Lourdes; Payer, Bernhard; Ruiz-Herrera, Aurora; Vazquez, Berta N.; Javierre, Biola M.; Vaquero, Alejandro; Lee, Jeannie T.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Institut de Recerca Contra la Leucemia Josep Carreras (IJC); Harvard University; Harvard Medical School; Rutgers University System; Rutgers University New Brunswick; Autonomous University of Barcelona; Autonomous University of Barcelona; Pompeu Fabra University; Barcelona Institute of Science & Technology; Centre de Regulacio Genomica (CRG); City University of New York (CUNY) System; Universite de Montreal; Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine
摘要：Sirtuins are deacetylases implicated in stress responses and longevity in mammals1,2. Although their differential impact on disease for the two sexes has been noted3, 4, 5, 6-7, the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7-/- female mice have decreased fitness throughout their lifespan. Notably, SIRT7 preferentially localizes to the sex chromosomes. In female individuals, SIRT7 loss affects X-...
作者：Song, Deguang; Duncan-Lowey, Brianna; Khetrapal, Varnica; Hamchand, Randy; Deng, Tong; Brown, Hailey; Wu, Anchi; Martin, Anjelica L.; Bauer, Kaylyn M.; Zhao, Yanyu; Nguyen, Mytien T.; Sonnert, Nicole D.; Leopold, Shana R.; Wu, Qihao; Crawford, Jason M.; Palm, Noah W.
作者单位：Yale University; Yale University; Yale University; Yale University; Yale University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：The microbiota produces thousands of potentially bioactive small molecules1, 2-3. High-throughput bioactivity screens of in vitro commensal cultures have exposed microbiota metabolites that shape host physiology by activating diverse G-protein-coupled receptors (GPCRs)4, 5, 6-7. However, owing to technical limitations, the GPCRome-wide bioactivities of in vivo metabolomes, which result from complex diet-microorganism-host interactions, remain unclear. Here we used a multiplexed GPCR screening ...
作者：Ransford, Anthony; Allman, M. S.; Arkinstall, Jake; Campora, J. P.; Cooper, Samuel F.; Delaney, Robert D.; Dreiling, Joan M.; Estey, Brian; Figgatt, Caroline; Hall, Alex; Husain, Ali A.; Isanaka, Akhil; Kennedy, Colin J.; Kotibhaskar, Nikhil; Madjarov, Ivaylo S.; Mayer, Karl; Milne, Alistair R.; Park, Annie J.; Reed, Adam P.; Ancona, Riley; Andersen, Molly P.; Andres-Martinez, Pablo; Angenent, Will; Argueta, Liz; Arkin, Benjamin; Ascarrunz, Leonardo; Baker, William; Barnes, Corey; Bartolotta, John; Berg, Jordan; Besand, Ryan; Bjork, Bryce; Blain, Matt; Blanchard, Paul; Blume-Kohout, Robin; Bohn, Matt; Borgna, Agustin; Botamanenko, Daniel Y.; Boutelle, Robert; Brown, Natalie; Buckingham, Grant T.; Burdick, Nathaniel Q.; Burton, William Cody; Carey, Varis; Carron, Christopher J.; Chambers, Joe; Chan, Jia Wen; Children, John; Colussi, Victor E.; Crepinsek, Steven; Cureton, Andrew; Davies, Joe; Davis, Daniel; DeCross, Matthew; Deen, David; Delaney, Conor; DelVento, Davide; DeSalvo, B. J.; Dominy, Jason; Drotar, Sydney; Duncan, Ross; Eccles, Vanya; Edgington, Alec; Erickson, Neal; Erickson, Stephen; Ertsgaard, Christopher T.; Esposito, Jay; Evans, Bruce; Evans, Tyler; Fabrikant, Maya I.; Fischer, Andrew; Foltz, Cameron; Foss-Feig, Michael; Francois, David; Freyberg, Brad; Gao, Charles; Garay, Robert; Garvin, Jane; Gaudiosi, David M.; Gilbreth, Christopher N.; Giles, Josh; Glynn, Erin; Graves, Jeff; Hansen, Azure; Hayes, David; Heidemann, Lukas; Higashi, Bob; Hilbun, Tyler; Hines, Jordan; Hlavaty, Ariana; Hoffman, Kyle; Hoffman, Ian M.; Holliman, Craig; Hooper, Isobel; Horning, Bob; Hostetter, James; Hothem, Daniel; Houlton, Jack; Hout, Jared; Hutson, Ross; Jacobs, Ryan T.; Jacobs, Trent; Johannsen, Melf; Johansen, Jacob; Jones, Loren; Julian, Sydney; Jung, Ryan; Keay, Aidan; Klein, Todd; Koch, Mark; Kondo, Ryo; Kong, Chang; Kosto, Asa; Lawrence, Alan; Liefer, David; Lollie, Michelle; Lucchetti, Dominic; Lysne, Nathan K.; Lytle, Christian; MacPherson, Callum; Malm, Andrew; Mather, Spencer; Mathewson, Brian; Maxwell, Daniel; McCaffrey, Lauren; McDougall, Hannah; Mendoza, Robin; Miller, David B.; Mills, Michael; Morrison, Richard; Narmour, Louis; Nguyen, Nhung; Nugent, Lora; Olson, Scott; Ouellette, Daniel; Parks, Jeremy; Peters, Zach; Peterson, Timothy A.; Petricka, Jessie; Pino, Juan M.; Polito, Frank; Potter, Andrew C.; Preidl, Matthias; Price, Gabriel; Proctor, Timothy; Pugh, McKinley; Ratcliff, Noah; Raymondson, Daisy; Rhodes, Peter; Roman, Conrad; Roy, Craig; Ryan-Anderson, Ciaran; Sanchez, Fernando Betanzo; Sangiolo, George; Sawadski, Tatiana; Schaffer, Andrew; Schow, Peter; Sedlacek, Jon; Semenenko, Henry; Shevchuk, Peter; Shore, Susan; Siegfried, Peter; Singhal, Kartik; Sivarajah, Seyon; Skripka, Thomas; Sletten, Lucas; Spaun, Ben; Sprenkle, R. Tucker; Stoufer, Paul; Tader, Mariel; Taylor, Stephen F.; Thompson, Travis H.; Tobey, Raanan; Tran, Anh; Tran, Tam; Vittorini, Grahame; Volin, Curtis; Walker, Jim; White, Sam; Williams, Garrett R.; Wilson, Douglas; Wolf, Quinn; Wringe, Chester; Young, Kevin; Zheng, Jian; Zuraski, Kristen; Baldwin, Charles H.; Chernoguzov, Alex; Gaebler, John P.; Sanders, Steven J.; Neyenhuis, Brian; Stutz, Russell; Bohnet, Justin G.
