36期

最新文章

• Genetic evidence and cross-species functional characterization implicate CNN2 in age-related macular degeneration susceptibility AI翻译
  作者：Cheng, Fei-Fei; Mou, Hao; Liu, Zhenyu; Zhang, Chang-Jun; Zhuang, You-Yuan; Wu, Zhen; Wen, Xin-Ran; Xue, Angli; Zhang, Xiao; Yang, Jian; Jin, Zi-Bing
  作者单位：Westlake University; Capital Medical University; Wenzhou Medical University; University of Queensland; Garvan Institute of Medical Research; University of New South Wales Sydney; Westlake Laboratory
  摘要：Age-related macular degeneration (AMD) is a leading cause of irreversible visual impairment in the aging population globally. Although genome-wide association studies (GWAS) have identified many AMD susceptibility loci, the genes and mechanisms underlying many of these associations remain unresolved. Here, we integrated expression quantitative trait locus (eQTL) data with AMD GWAS to prioritize nine putative genes. Through in vivo screening in zebrafish, we demonstrated that the downregulation...
• Affect labeling down-regulates amygdala only in a dominant native language AI翻译
  作者：Davydova, Tatiana; Marin Marin, Lidon; Cherednichenko, Anastasia; Fengler, Alexander; Adrian Ventura, Jesus; Palomar Garcia, Maria de los Angeles; Vives, Marc-Lluis; Costumero, Victor
  作者单位：Universitat Jaume I; Brown University; University of Zaragoza; Leiden University; Leiden University - Excl LUMC
  摘要：A successful strategy to down-regulate emotions is to simply label them (e.g., saying I'm sad when feeling sad). It however remains unresolved which mechanism is responsible for the efficacy of this approach known as affect labeling. Here, we constrain the proposed mechanisms of affect labeling by testing the scope of affect labeling in a new population previously neglected: bilinguals. Specifically, we examined two bilingual groups (Spanish-English, Spanish-Catalan) that varied in language do...
• A two-factor authentication mechanism licenses pilins for pilus assembly in gram-positive bacteria AI翻译
  作者：Cheung, Nicole A.; Pawlaczyk, Reece M.; Mahoney, Brendan J.; Day, Shania D.; Cheatham, Kade; Goring, Andrew K.; Minor, Christine M.; Chan, Rose W.; Chang, Chungyu; Loo, Joseph A.; Wereszczynski, Jeff; Ton-That, Hung; Clubb, Robert T.
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Illinois Institute of Technology; Illinois Institute of Technology
  摘要：Gram-positive bacteria display virulence-associated pili that facilitate adhesion and biofilm formation. These pili are covalently polymerized by class C sortase enzymes, which selectively recognize their cognate pilin substrates amid numerous cell wall sorting signal (CWSS)-bearing proteins. The molecular basis for this stringent substrate specificity has remained unclear. Here, we develop a rapid, quantitative fluorescence-activated cell sorting assay to monitor pilus assembly in Corynebacte...
• Flagellar toxicity: Flagellar synthesis is lytic for Bacillus subtilis in the absence of PBP1 AI翻译
  作者：Dunn, Caroline M.; Adebiyi, Kehinde O.; Kearns, Daniel B.
  作者单位：Indiana University System; Pennsylvania State System of Higher Education (PASSHE); Indiana University Bloomington; Indiana University of Pennsylvania
  摘要：Flagella are large transenvelope nanomachines but how they transit the peptidoglycan in gram-positive bacteria is poorly understood. A recent model suggested that flagellar basal bodies diffuse in the membrane and become captured at locations in the peptidoglycan with a pore diameter that could accommodate the axle-like flagellar rod. To test the role of pore size on flagellar assembly, cells were disrupted for penicillin binding protein 1 (PBP1/PonA), a cell wall synthesis protein thought to ...
• Cell body position of Drosophila Moonwalker Descending Neurons regulates locomotor circuit function AI翻译
  作者：Lee, Kristen; Graciani, Josmarie; Carvajal, Natalie Rico; Zhu, Zhehao; Clark, Matt Q.; Doe, Chris Q.
  作者单位：University of Oregon; University of Oregon
  摘要：Both mammalian and invertebrate nervous systems contain densely packed neuronal cell bodies in stereotyped locations, which express cell surface molecules and gap junction proteins. An open question that has rarely been addressed is: What role does cell body position play in neuronal circuit function? Here we show that the four adult Drosophila Moonwalker Descending Neurons (MDNs), command neurons for backward locomotion, must maintain cell body contact to initiate backward walking. MDNs expre...
• State-sponsored agenda setting: Measuring the impact of narrative laundering AI翻译
  作者：Warren, Patrick L.; Linvill, Darren L.; Saucier, Camille J.
  作者单位：Clemson University; Clemson University; Clemson University
  摘要：Foreign information manipulation and interference (FIMI) is an important part of the digital information ecosystem, yet its effects are poorly understood. Most research analyzing FIMI to date is descriptive, exposing efforts to erode trust, promote favorable narratives, and target specific communities. Existing work evaluating the impacts of FIMI contrasts those directly exposed to FIMI messaging (by viewing the original messages) with those who were not, finding little evidence of changes in ...
• Ancient DNA reveals early use of melons in China's Song dynasty AI翻译
  作者：Walker-Hale, Nathanael; Zheng, Yunfei; Verdenaud, Marion; Pereira, Lara; Perez-Escobar, Oscar Alejandro; Preick, Michaela; Bendahmane, Abdelhafid; Westbury, Michael V.; Hofreiter, Michael; Schaefer, Hanno; Liu, Xinyi; Chomicki, Guillaume; Renner, Susanne S.
  作者单位：Durham University; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Universite Paris Cite; University of Sheffield; Royal Botanic Gardens, Kew; University of Potsdam; University of Copenhagen; Technical University of Denmark; Technical University of Munich; Washington University (WUSTL); Washington University (WUSTL)
  摘要：Melon (Cucumis melo L.) domestication is thought to have occurred independently once in Northeast Africa and twice in India, but archaeobotanical seed remains point to a possible additional domestication event in China. Because Cucumis seeds are difficult to diagnose morphologically, genomic data from archaeological material are needed to evaluate these scenarios and reconstruct ancient melon traits. We sequenced two Song Dynasty (960-1279 CE) melon seeds from Shuomen Gugang (China), recoverin...
• Genetic architectures of brain-related traits are shaped by strong selective constraints AI翻译
  作者：Zhu, Huisheng; Simons, Yuval B.; Spence, Jeffrey P.; Sella, Guy; Pritchard, Jonathan K.
  作者单位：Stanford University; Stanford University; Stanford Medicine; University of Chicago; University of Chicago; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Columbia University; Columbia University
  摘要：Genome-wide association studies (GWAS) have identified hundreds of significant loci for psychiatric disorders, yet the strength of these associations remains modest compared to other human complex traits with similar numbers of hits. Whether this pattern reflects statistical artifacts or real biological differences-and, if the latter, what underlies it-remains unclear. In addition to psychiatric disorders, we find that other traits with functional enrichment in the central nervous system (CNS)...
• Pregnancy diet based on ancestral patterns increases growth in subcortical fetal brain regions AI翻译
  作者：Iannotti, Lora L.; Vintimilla Andrade, Gabriela; Tipanquiza Piedra, Shirley; Zimmerman, Rachel B.; Hahn, Elizabeth; Camana, Pamela; Baldeon, Dessire; Silva, Paul; Balladares, Karen; Gallegos-Riofrio, Carlos Andres; Chapnick, Melissa; Aboagye-Mensah, Gifty; Zielonko, Timothy; Raichle, Marcus; Goyal, Manu S.; Waters, William F.; Palacios Leon, Ivan; Nicholas, Jennifer
  作者单位：Washington University (WUSTL); University of Vermont; Emory University; Rollins School Public Health; Washington University (WUSTL); Washington University (WUSTL); University of Colorado System; University of Colorado Anschutz
  摘要：Evidence on the biological basis for maternal nutrition effects on fetal and newborn neurodevelopment remains limited. This randomized controlled trial in Ecuador tested a maternal dietary pattern-derived from empirical studies of nutrition in human evolution and adapted locally-on offspring growth and brain development. Pregnant women (n = 215) in their first trimester were randomized to: 1) control (n = 104); or 2) Mikhuna (nourish in Kichwa) intervention (n = 111). The intervention, from 12...
• AML1-ETO hijacks a distal enhancer of NAT10 to reprogram glutathione metabolism and sustain leukemia stem cell stemness AI翻译
  作者：Li, Shuyi; He, Shujiao; Su, Yongwei; Wang, Lei; Wang, Yiran; Xu, Yuanyuan; Yu, Li; Zhou, Jingfeng
  作者单位：Shenzhen University; Shenzhen University
  摘要：Chromosomal translocations produce oncogenic fusion proteins such as AML1-ETO, which predominantly occupy gene promoters to induce transcriptional reprogramming in leukemia stem cells (LSCs), consequently driving the pathogenesis of t(8;21) acute myeloid leukemia (AML). However, whether AML1-ETO is recruited to additional regulatory DNA elements to orchestrate oncogenic gene expression programs has not been fully addressed. Here, we define AML1-ETO and H3K27ac CUT&Tag landscapes in primary t(8...