48期

最新文章

• Cartesian equivariant representations for learning and understanding molecular orbitals AI翻译
  作者：King, Daniel S.; Grzenda, Daniel; Zhu, Ray; Hudson, Nathaniel; Foster, Ian; Cheng, Bingqing; Gagliardi, Laura
  作者单位：University of Chicago; University of Chicago; United States Department of Energy (DOE); Argonne National Laboratory; University of California System; University of California Berkeley; Institute of Science & Technology - Austria; University of California System; University of California Berkeley; University of Chicago
  摘要：Qualitative and quantitative orbital properties such as bonding/antibonding character, localization, and orbital energies are critical to how chemists understand reactivity, catalysis, and excited-state behavior. Despite this, representations of orbitals in deep learning models have been very underdeveloped relative to representations of molecular geometries and Hamiltonians. Here, we apply state-of-the-art equivariant deep learning architectures to the task of assigning global labels to orbit...
• Nonionic signaling rapidly remodels postsynaptic DLG to induce retrograde homeostatic plasticity AI翻译
  作者：Qiu, Chengjie; Perry, Sarah; Chen, Christine; Chen, Jiawen; Zhuang, Jin; Han, Yifu; Goel, Pragya; Dickman, Dion; Jin, Yishi
  作者单位：University of Southern California; University of Southern California
  摘要：Synapses must be resilient to the challenges they confront during development, experience, disease, and aging. A conserved form of adaptive plasticity, observed at the glutamatergic Drosophila neuromuscular junction (NMJ), is expressed following acute pharmacological blockade of postsynaptic glutamate receptors (GluRs). This challenge is counteracted by enhanced presynaptic neurotransmitter release to maintain stable synaptic strength. This retrograde form of homeostatic plasticity is termed p...
• Immunogenic cell death unlocks the potential for combined radiation and immunotherapy AI翻译
  作者：Rauf, Somiya; Smirnova, Alexandra; Chang, Andres; Liu, Yuan; Jiang, Yi
  作者单位：University System of Georgia; Georgia State University; Emory University; Nanjing University
  摘要：Immunogenic cell death (ICD) enhances antitumor immunity by releasing tumor-associated antigens and activating the antitumor immune system response. Here, we develop a mathematical model to quantify the role of ICD in optimizing the efficacy of combined radiotherapy (RT) and macrophage-based immunotherapy. Using preclinical murine data targeting the SIRPa-CD47 checkpoint, we show that RT alone induces minimal ICD, whereas disrupting the SIRPa-CD47 axis significantly enhances both phagocytosis ...
• Regulated coexpression of PrP from different species in mice impacts the replication and host range properties of prion strains AI翻译
  作者：Defranco, Joseph P.; Bian, Jifeng; Kim, Sehun; Atkinson, Zoe N.; Crowell, Jenna; Kang, Hae - Eun; Bodrogi, Hannah O.; Christiansen, Jeffrey R.; Telling, Glenn C.
  作者单位：Colorado State University System; Colorado State University Fort Collins
  摘要：Our previous demonstration that replacement of murine cellular prion protein (PrPC) expression with elk or deer PrPC eliminated the resistance of mice to chronic wasting disease (CWD) prions from deer, elk, and other cervids highlighted the importance of sequence homology between PrPC and its conformationally altered counterpart (PrPSc) for optimal prion replication. To further investigate the effects of species-specific PrP primary structural variation on the evolution of prion host range and...
• USP1-TRAF2 axis-regulated mortalin stability mediates chemoresistance by disrupting calcium transport in peripheral T-cell lymphoma AI翻译
  作者：Gui, Ailing; Yan, Yichen; Jiang, Shiyu; Chen, Feng; Zhou, Xiaolong; Sun, Qi; Qiu, Shi; Wu, Jichuan; Li, Xiya; Zhang, Junyi; Liu, Jie; Zhu, Shun; Wang, Lan; Liu, Wen; Zuo, Ji; Zhang, Qunling; Yang, Ling
  作者单位：Fudan University; Fudan University; Fudan University; Shanghai Jiao Tong University; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS
  摘要：Ubiquitin-specific peptidase 1 (USP1) plays a critical role in the progression and chemoresistance of various cancers, making USP1 inhibitors a promising therapeutic option in cancer treatment. However, the role of USP1 in peripheral T-cell lymphoma (PTCL) has remained unexplored. Our study uncovers a USP1-dependent survival axis driving chemoresistance in PTCL. USP1 is significantly upregulated in PTCL patients and correlates with poor prognosis through promoting mortalin degradation via TRAF...
• Engineered calcium- regulated affinity protein for efficient internalization and lysosomal toxin delivery AI翻译
  作者：Jonsson, Malin; Moller, Marit; Schierholz, Leon; Dorka, Nicolai; Tegel, Hanna; Lundberg, Emma; Uhlen, Mathias; Wolf-Watz, Magnus; Brismar, Hjalmar; Hober, Sophia
  作者单位：SciLifeLab; Royal Institute of Technology; Umea University; Stanford University; Umea University; SciLifeLab; Royal Institute of Technology
  摘要：The emerging strategy of protein-drug conjugates (PDCs) for targeted cancer therapy holds great potential to improve treatment efficacy by specifically targeting cancer biomarkers and delivering toxic payloads directly to tumor cells, minimizing off-target toxicity.The success of this approach depends on the internalization and retention of the payload in target cells. This study introduces a method using a small protein domain engineered for conditional target affinity, enabling lysosomal tra...
• Using gnotobiotic mice to decipher effects of gut microbiome repair in undernourished children on tuft and goblet cell function AI翻译
  作者：Wang, Yi; Chang, Hao-Wei; Cheng, Jiye; Webber, Daniel M.; Lynn, Hannah M.; Hibberd, Matthew C.; Kao, Clara; Mostafa, Ishita; Ahmed, Tahmeed; Barratt, Michael J.; Gordon, Jeffrey I.
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); International Centre for Diarrhoeal Disease Research (ICDDR)
  摘要：Studies have implicated perturbations in the postnatal development of the gut microbiome as a contributing factor to childhood undernutrition. Compared to a standard ready-to-use supplementary food, a microbiome-directed complementary food (MDCF-2) designed to repair these perturbations produced superior improvements in ponderal and linear growth in clinical trials of Bangladeshi children with moderate acute malnutrition. Here, reverse translation experiments are performed where intact fecal m...
• Precipitation increase promotes soil organic carbon formation and stability via the mycorrhizal fungal pathway AI翻译
  作者：He, Tangqing; Zhao, Yunfeng; Wang, Xiaodong; Qiu, Yunpeng; Deng, Jun; Zhang, Kangcheng; Xu, Xinyu; Zhao, Yexin; Qian, Kaiyun; Wang, Hao; Bai, Tongshuo; Zhang, Yi; Feng, Cheng; Guo, Lijin; Chen, Huaihai; Guo, Liang; Wang, Yi; Hu, Shuijin
  作者单位：Nanjing Agricultural University; Nanjing Agricultural University; University of Tokyo; Fujian Agriculture & Forestry University; Sun Yat Sen University; Northwest A&F University - China; Ministry of Water Resources; Chinese Academy of Sciences; Institute of Soil & Water Conservation (ISWC), CAS; Chinese Academy of Sciences; Institute of Earth Environment, CAS
  摘要：Arbuscular mycorrhizal fungi (AMF) form symbiotic relationships with roots of most terrestrial plants, playing a crucial role in regulating soil organic carbon (SOC) dynamics. While precipitation increase (Pi) is a major facet of climate change, its impacts on root- and AMF- mediated SOC formation and stability remain largely unexplored. Here, we combined a meta- analysis across global grasslands with a multiyear precipitation manipulation experiment in a semiarid grassland on the Loess Platea...
• Reaching the full potential of cryo- EM reconstructions with molecular dynamics simulations at 310 K: Actin filaments as an example AI翻译
  作者：Iyer, Sahithya Sridharan; Herman, Kristina M.; Paul, Tamsuk; Wang, Yihang; Pollard, Thomas D.; Voth, Gregory A.
  作者单位：University of Chicago; University of Chicago; Yale University; Yale University; Yale University; University of California System; University of California Berkeley
  摘要：Cryoelectron microscopy (cryo- EM) structures of multiprotein complexes such as actin filaments help explain the mechanisms of assembly and interactions with partner proteins. Yet, rapid cooling during freezing may not preserve the conformations at physiological temperature. All- atom molecular dynamics simulations starting with cryo- EM reconstructions can provide additional insights. For example, at 310 K, adenosinediphosphate (ADP)- actin filaments fluctuate on a nanosecond time scale aroun...
• A balance of metabolism and diffusion articulates a gibberellin hormone gradient in the Arabidopsis root AI翻译
  作者：Kiradjiev, Kristian B.; Griffiths, Jayne; Jones, Alexander M.; Band, Leah R.
  作者单位：University of Nottingham; University of Cambridge; University of Nottingham
  摘要：The plant hormone gibberellin (GA4) regulates numerous developmental processes. Within the root, GA4 controls growth, in part, by controlling the extent of cell elongation. The nlsGPS1 FRET biosensor revealed a GA4 gradient within the Arabidopsis root growth zones, with GA4 levels correlating with cell length. We developed a multiscale mathematical model to understand how biosynthesis, catabolism, and transport create the GA4 distribution within the root growth zones. The model predicted that ...