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作者：Deichler, Alfonso; Ruiz-Flores, Macarena; Marquez, Natalia I.; Morales, Cristian; Lopez-Jury, Luciana; Vega-Zuniga, Tomas; Mpodozis, Jorge; Faunes, Macarena; Marin, Gonzalo J.
作者单位：Universidad de Chile; Pontificia Universidad Catolica de Chile; Pontificia Universidad Catolica de Chile; Universidad Finis Terrae
摘要：Binocular vision requires both eyes to be aligned such that their visual fields overlap. A long-standing premise derived from comparative studies is that the orientation of the orbits determines eye position, and thereby the extension of this overlap, the binocular field. In addition, to produce an accurate neural representation, the binocular field must integrate with the position of retinal high-acuity areas and with the extent of uncrossed retinal projections. It remains unknown, however, w...
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作者：Comani, Valeria Buoli; De Bei, Omar; Paris, Giulia; Marchetti, Marialaura; Pancrazi, Francesca; Campanini, Barbara; Ronda, Luca; Luisi, Ben F.; Faggiano, Serena; Bizzarri, Anna Rita; Bettati, Stefano
作者单位：University of Parma; University of Parma; University of Parma; University of Cambridge; Tuscia University; Consiglio Nazionale delle Ricerche (CNR); Istituto di Biofisica (IBF-CNR)
摘要：Staphylococcus aureus is a human pathogen whose virulence depends on iron acquisition. The bacterium expresses the hemophores IsdB and IsdH that enable heme capture from host hemoglobin (Hb). Unlike IsdB, IsdH can bind both free Hb and Hb:haptoglobin (Hb:Hp) complexes. Here, we present a comprehensive structural analysis of full-length IsdH in complex with free Hb, overcoming the limitations of previous studies based on truncated IsdH constructs. Cryo-EM revealed a previously unobserved oligom...
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作者：Ravindran, Sandeep
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作者：Tanosaki, Sho; Zhang, Yuan; Bedi, Kenneth; Margulies, Kenneth; Cox, James E.; Arany, Zoltan; Abel, E. Dale
作者单位：University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah
摘要：Cardioplegia is often used prior to acquisition of human cardiac tissue to minimize warm ischemia time, which can severely confound studies of cardiac metabolism. However, there are several choices of cardioplegia solutions, and whether these solutions differentially impact tissue metabolism or metabolomic studies is not known. Here, we perform untargeted metabolomics, using both liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry, on a large cohort of hearts trans...
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作者：Zhong, Chengxi; Winderoll, Vincent; Kshetri, Khemraj Gautam; Dillinger, Cornel; Bianchi, Tommaso; Shi, Zhan; Schnermann, Justus; Amabili, Marco; Liu, Song; Wittkowski, Raphael; Nama, Nitesh; Ahmed, Daniel
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; ShanghaiTech University; University of Nebraska System; University of Nebraska Lincoln; University of Geneva; University of Bern; Westlake University; RWTH Aachen University; Leibniz Association; DWI Leibniz Institute for Interactive Materials; University of Munster
摘要：Understanding how acoustic waves interact with soft matter is critical for developing new strategies for dynamic control, actuation, sensors, and manipulation at small scales. A major challenge in soft matter and microrobotics is how to achieve fast, precise, and remotely controlled actuation at the microscale without sacrificing compliance or biocompatibility. Here, we introduce wireless artificial microcilia based on acoustically activated soft hydrogel microstructures inspired by Venus flyt...
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作者：Ahn, Da-Hee; Chae, Tong Un; Lee, Sang Yup
作者单位：Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST)
摘要：Hexamethylenediamine (HMD), adipic acid, and epsilon-caprolactam (epsilon-CL) are essential C6 monomers used in the production of nylon 6,6 and nylon 6. Developing sustainable, bio-based routes to these compounds remains challenging due to pathway complexity. Here, we report a modular Escherichia coli platform for the de novo biosynthesis of all three monomers directly from glycerol. We divided the overall pathway into upstream and downstream modules, with the upstream module converting glycer...
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作者：Park, Sungmo; Wu, Bozhi; Zbaranska, Sofiya; Lee, Joseph; Jacob, Alexander D.; Hoorn, Annelies; Mocle, Andrew; Luchetti, Alessandro; Chen, Mahe; Jung, Jung Hoon; Frankland, Paul W.; Josselyn, Sheena A.
作者单位：University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; University of Toronto; Canadian Institute for Advanced Research (CIFAR)
摘要：Memories are encoded by sparsely distributed neuronal ensembles, or engrams, yet how newly allocated engram neurons are consolidated to support subsequent memory retrieval remains unclear. While offline reactivation has been extensively studied in hippocampal circuits, whether similar ensemble-level dynamics support consolidation of emotional memories in the amygdala is unknown. Here we combine longitudinal in vivo calcium imaging, temporally precise activity-dependent neuronal tagging, and op...
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作者：Singh, Pooja; Ahi, Ehsan Pashay; Duenser, Anna; Durdevic, Marija; Gessl, Wolfgang; Schaeffer, Sylvia; Gallaun, Julian; Seehausen, Ole; Sturmbauer, Christian
作者单位：University of Graz; University of Bern; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); University of Helsinki; Medical University of Graz; Medical University of Graz
摘要：Adaptive radiation is a major driver of biodiversity. In some of the largest radiations, increasing evidence suggests that explosive morphological diversification is often fueled by standing genetic variation and admixture, rather than de novo mutations. The rapid translation of this genetic variation into novel phenotypes through gene regulation remains poorly understood. Analyzing 200 transcriptomes from three independent but phylogenetically nested African cichlid adaptive radiations, we sh...
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作者：Zhang, Quan
作者单位：University of Hawaii System; University of Hawaii System; University of Hawaii System
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作者：Dwivedi, Jyotirmay; Islam, Saurav; Morris, Jake; Halanayake, Kalana D.; Vazquez-Lizardi, Gabriel A.; Snyder, David; Richardella, Anthony; Lyle, Luke; Reifsnyder Hickey, Danielle; Delegan, Nazar; Heremans, F. Joseph; Awschalom, David D.; Samarth, Nitin
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; United States Department of Energy (DOE); Argonne National Laboratory; University of Chicago; United States Department of Energy (DOE); Argonne National Laboratory; University of Chicago
摘要：Two decades since its discovery, superconducting heavily boron-doped diamond (HBDD) still poses fundamental questions that need to be answered to unlock its full potential for quantum applications. We use electrical magnetotransport measurements of critically doped homoepitaxial single crystal HBDD films to reveal signatures of intrinsically granular superconductivity. By studying the dependence of electrical resistivity on temperature and magnetic field vector, we infer that this granularity ...
