20期

最新文章

• Selective divergence between Grokipedia and Wikipedia articles AI翻译
  作者：Mohammadi, Saeedeh; Yasseri, Taha
  作者单位：Trinity College Dublin; University College Dublin
  摘要：The launch of Grokipedia, an AI-generated encyclopedia developed by xAI, was presented as a response to perceived ideological and structural biases in Wikipedia, with the goal of producing more truthful entries using the Grok large language model. However, whether such an AI-driven alternative can systematically correct the biases and limitations of human-edited platforms remains unclear. Here we conduct a large-scale computational comparison of 17,790 matched article pairs drawn from the 20,0...
• Directly adopting inverse biosensors to image live cell enzyme activities in nanodomains AI翻译
  作者：Srivastava, Kriti; Schnur, Kevin P.; Petruzzi, Kay; Mo, Gary C. H.
  作者单位：University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago
  摘要：Many biochemical pathways can be monitored by outfitting molecular switches with reporting mechanisms such as fluorescence. The output of these biosensors can either increase or decrease upon target activation. Both types can report average relative changes in time. But a na & iuml;ve imaging of inverse biosensors, which gives readout decrease, will form nonsensical images by giving low values to both the background and foreground. Thus, currently, superresolution enzyme activity imaging canno...
• A molecular lattice reinforces the sperm head-tail junction AI翻译
  作者：Wood, Anna J.; Liu, Pulan; Tang, Shaogeng
  作者单位：Yale University; Yale University
• Predicting rates of manganese oxide reduction from thermodynamic driving forces and structural properties AI翻译
  作者：Liu, Xinru; Pothanamkandathil, Vineeth; Schwab, Lorenz; Mao, Shun; Aeppli, Meret
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Tongji University
  摘要：Manganese (oxyhydr)oxides are abundant redox-active minerals that influence diverse biogeochemical processes, yet their redox reactivity remains poorly understood due to variations in mineral structure and manganese oxidation state. We quantified the reduction kinetics of three geochemically relevant manganese oxides-birnessite, manganite, and hausmannite-using extracellular electron shuttles with varying redox potentials to systematically modulate the driving force for electron transfer. Whil...
• Cysteine thiol-to-sulfonate oxidation induces unfolding for the functional switching of the extracellular HMGB1 protein AI翻译
  作者：Paz-Villatoro, Jonathan M.; Yu, Binhan; Songe, Orion; Wang, Xi; Iwahara, Junji
  作者单位：University of Texas System; University of Texas Medical Branch Galveston
  摘要：Oxidation of cysteine thiols to sulfonate groups (-SO3 -) by reactive oxygen species can regulate protein function. Near the end of inflammation, this modification in the extracellular HMGB1 protein abolishes its proinflammatory activity. Using NMR spectroscopy, we investigated how thiol-to-sulfonate oxidation switches HMGB1's function. Our data show that the oxidation of cysteine 106 (C106) induces unfolding of the HMGB1 B-box domain. In contrast, other chemical modifications, such as S-gluta...
• Educational policies can strengthen climate coalitions AI翻译
  作者：Bradley, Max; Chazottes, Rens; Garside, Susanna; Lopez-Uroz, Nina
  作者单位：European University Institute; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Oxford; Max Planck Society
  摘要：Building public support for ambitious climate policies is a central challenge for governments seeking to decarbonize their economies. Many climate change mitigation policies impose visible material costs on citizens, and governments have limited fiscal capacity to deploy compensatory measures. Education is often used as a tool to build public awareness about climate change, but its effect on support for climate policies is not well understood. We evaluate the effects of a climate education pol...
• Reply to Zhang: Causal identification, social networks, and biological aging AI翻译
  作者：Lee, Byungkyu; Ciciurkaite, Gabriele; Peng, Siyun; Mitchell, Colter; Perry, Brea L.
  作者单位：New York University; University of Michigan System; University of Michigan; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington
• A brain circuit of bidirectional modulation of social and nonsocial cognition by androgens and estrogens in male mice AI翻译
  作者：Aspesi, Dario; Varatharajah, Anjana; Cioffi, Lucia; Diviccaro, Silvia; Caruso, Donatella; Becke, Natalina; Lalonde, Jasmin; Perreault, Melissa L.; Melcangi, Roberto C.; MacLusky, Neil J.; Choleris, Elena
  作者单位：University of Guelph; University of Guelph; University of Milan; University of Guelph; University of Guelph
  摘要：Androgens and estrogens rapidly influence brain function and behaviors critical to social species, including social recognition, which is essential for group living and modulating social interactions. The specific brain regions involved and their hormonal regulation remain poorly understood. This regulation is complex, as the main circulating androgen, testosterone (T), is metabolized into estrogenic (17 beta-estradiol, E2) and androgenic (dihydrotestosterone, DHT) compounds, meaning its actio...
• Observing the mechanism of delayed collapse in colloidal gels: Yielding while becoming stronger AI翻译
  作者：Cheng, Rui; Faers, Malcolm A.; Turci, Francesco; Mauleon-Amieva, Abraham; Liverpool, Tanniemola B.; Jack, Robert L.; Royall, C. Patrick
  作者单位：Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Bayer AG; University of Bristol; University of Bristol; University of Cambridge; University of Cambridge; University of Warwick
  摘要：The delayed collapse of colloidal gels is a vexing problem. Although the equilibrium behavior of colloid-polymer mixtures is well understood, that of far-from-equilibrium gels is surprisingly complex. As the gels age, they become stronger due to coarsening but exhibit no other macroscopic change. Quite counterintuitively for a material whose strength increases with time, gels may undergo sudden, catastrophic collapse under gravity, sometimes weeks or even years after preparation. An understand...
• SFTSV NSs protein is a tick antiviral RNAi response suppressor AI翻译
  作者：Fares, Mazigh; McFarlane, Melanie; Parry, Rhys H.; Arif, Rozeena; Clarke, Andrew T.; Kamel, Wael; Davies, Kelsey; Datta-Savage, Riona; Schwarz-Linek, Ulrich; Bell-Sakyi, Lesley; Petit, Marine J.; Schnettler, Esther; Castello, Alfredo; Kohl, Alain; Brennan, Benjamin
  作者单位：UK Research & Innovation (UKRI); University of Glasgow; Medical Research Council UK (MRC); University of Queensland; University of St Andrews; University of Liverpool; University of Surrey; Leibniz Association; Bundeswehrkrankenhaus Hamburg; Bernhard Nocht Institut fur Tropenmedizin; German Center for Infection Research; University of Hamburg; Liverpool School of Tropical Medicine
  摘要：Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne phenuivirus causing high mortality in humans. While the nonstructural protein NSs is dispensable for replication in interferon-deficient mammalian cells, we demonstrate that NSs is essential for viral replication in tick cells. SFTSV infection triggers canonical Dicer-2-mediated antiviral RNA interference (RNAi) in tick cells, producing virus-derived small interfering RNAs (siRNAs) that target viral transcripts...