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作者：Bayramov, Zaur; Viltres, Renier; Doubre, Cecile; Maggi, Alessia; Jolivet, Romain; Rivera, Luis
作者单位：Centre National de la Recherche Scientifique (CNRS); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Ministry of Education of Azerbaijan Republic; Azerbaijan State University of Oil & Industry (ASUOI); Centre National de la Recherche Scientifique (CNRS); Universite PSL; CNRS - National Institute for Earth Sciences & Astronomy (INSU); Ecole Normale Superieure (ENS); Institut Universitaire de France
摘要：Seismic waves from large earthquakes are known to trigger slip on distant faults, but the underlying mechanisms remain unclear. Using interferometric synthetic aperture radar and local geodetic and seismic data, we show that the 1000-kilometer-distant, February 2023 Kahramanmara & scedil; earthquakes in southeastern T & uuml;rkiye triggered deformation and/or eruption at 56 mud volcanoes and centimeter-scale aseismic slip on seven faults over tens of kilometers within the fluid-rich Kura Basin...
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作者：Conte, Carolina; Angelotti, Maria Lucia; Mazzinghi, Benedetta; Melica, Maria Elena; Antonelli, Giulia; Carangelo, Giulia; Landini, Samuela; Raglianti, Valentina; Ravaglia, Fiammetta; Cirillo, Luigi; Fantini, Camilla; Dafichi, Tommaso; Klaus, Martin; Lucenteforte, Ersilia; Molli, Alice; De Chiara, Letizia; Peired, Anna Julie; Lazzeri, Elena; Anders, Hans-Joachim; Lasagni, Laura; Romagnani, Paola
作者单位：University of Florence; University of Florence; Azienda Ospedaliera Universitaria (AOU) MEYER; University of Munich; University of Florence
摘要：The global burden of kidney disease displays marked sexual dimorphism. Lineage tracing and single-cell RNA-sequencing revealed that starting from puberty, estrogen signaling in female mice supports self-renewal and differentiation of renal progenitors to increase filtration capacity, reducing sensitivity to glomerular injury compared with that of males. This phenomenon accelerated as female kidneys adapted to the workload of pregnancy. Deletion of estrogen receptor alpha in renal progenitors d...
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作者：Eyunni, Sanjana; Mannan, Rahul; Zhang, Yuping; Young, Eleanor; Zhang, Qiuyang; Luo, Jie; Pang, Matthew; Mahapatra, Somnath; Tien, Jean Ching-Yi; George, James M.; Jaber, Mustapha; Hakkani, Hamzah; Carson, Sandra E.; Todd, Abigail J.; Hosseini, Noshad; Gondal, Mahnoor; Rebernick, Ryan J.; Cao, Xuhong; Su, Fengyun; Wang, Rui; Mehra, Rohit; Li, Jing; Cieslik, Marcin; Chinnaiyan, Arul M.; Parolia, Abhijit
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Howard Hughes Medical Institute; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Naval Medical University; University of Michigan System; University of Michigan
摘要：FOXA1 is altered in 10 to 40% of prostate cancers, yet its oncogenic mechanisms remain uncharacterized in vivo. We developed knock-in mouse models representing distinct classes of FOXA1 mutations. Histopathological and multiomic analyses of prostate tissues and organoids revealed that Class 1 mutations, in conjunction with p53 inactivation, drive androgen-dependent adenocarcinomas through coactivation of mTORC1/2 and oncogenic AR signaling stemming from chimeric AR-half enhancers. By contrast,...
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作者：Wyatt, Brian C.; Yang, Yinan; Michalowski, Pawel P.; Parker, Tetiana; Morency, Yamilee; Urban, Francesca; Kadagishvili, Givi; Tanwar, Manushree; Muhoza, Sixbert P.; Nemani, Srinivasa Kartik; Bedford, Annabelle; Fang, Hui; Hood, Zachary D.; Jang, Junwoo; Kamath, Krutarth; Wright, Bethany G.; Disko, Rebecca; Thakur, Anupma; Han, Sanguk; Ghosh, Neil; Xu, Xianfan; Fakhraai, Zahra; Gogotsi, Yury; Vojvodic, Aleksandra; Jiang, De-en; Anasori, Babak
作者单位：Purdue University System; Purdue University; Vanderbilt University; Drexel University; Drexel University; University of Pennsylvania; University of Pennsylvania; United States Department of Energy (DOE); Argonne National Laboratory; Purdue University System; Purdue University; Purdue University in Indianapolis; University of Alabama System; University of Alabama Birmingham
摘要：In compositionally complex materials, there is controversy on the effect of enthalpy versus entropy on the structure and short-range ordering in so-called high-entropy materials. To help address this controversy, we synthesized and probed 40 M4AlC3 layered carbide phases containing two to nine metals and found that short-range ordering from enthalpy was present until the entropy increased enough to achieve complete disordering of the transition metals in their atomic planes. We transformed all...
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作者：Fu, Jiarui; Nakamuro, Takayuki; Nakamura, Eiichi
作者单位：University of Tokyo; Nankai University; Nankai University
摘要：Diamond and adamantane (Ad) share a Td-symmetric carbon skeleton, but converting Ad to diamond has been challenging because it requires selective carbon-hydrogen (C-H) bond cleavage and monomer assembly into a diamond lattice. Our approach differs from the conventional high-temperature, high-pressure diamond syntheses. We electron-irradiated Ad submicrocrystals at 80 to 200 kilo-electron volts and 100 to 296 kelvin in vacuum for tens of seconds. This process yielded defect-free nanodiamonds (N...
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作者：Buchli, Jonas; Tracey, Brendan; Andric, Tomislav; Wipf, Christopher; Chiu, Yu Him Justin; Lochbrunner, Matthias; Donner, Craig; Adhikari, Rana X.; Harms, Jan; Barr, Iain; Hafner, Roland; Huber, Andrea; Abdolmaleki, Abbas; Beattie, Charlie; Betzwieser, Joseph; Cabi, Serkan; Degrave, Jonas; Dong, Yuzhu; Fritz, Leslie; Gupta, Anchal; Groth, Oliver; Huang, Sandy; Norman, Tamara; Openshaw, Hannah; Rollins, Jameson; Thornton, Greg; van den Driessche, George; Wulfmeier, Markus; Kohli, Pushmeet; Riedmiller, Martin
作者单位：Alphabet Inc.; Google Incorporated; DeepMind; Gran Sasso Science Institute (GSSI); Gran Sasso Science Institute (GSSI); California Institute of Technology
摘要：Improved low-frequency sensitivity of gravitational wave observatories would unlock study of intermediate-mass black hole mergers and binary black hole eccentricity and provide early warnings for multimessenger observations of binary neutron star mergers. Today's mirror stabilization control injects harmful noise, constituting a major obstacle to sensitivity improvements. We eliminated this noise through Deep Loop Shaping, a reinforcement learning method using frequency domain rewards. We prov...
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作者：Zhang, Xiaodi; Liu, Haiqing; Wu, Xiao; Jia, Longgang; Gadhave, Kundlik; Wang, Lena; Zhang, Kevin; Li, Hanyu; Chen, Rong; Kumbhar, Ramhari; Wang, Ning; Terrillion, Chantelle E.; Kang, Bong Gu; Bai, Bin; Park, Minhan; Denna, Ma. Cristine Faye; Zhang, Shu; Zheng, Wenqiang; Ye, Denghui; Rong, Xiaoli; Yang, Liu; Niu, Lili; Ko, Han Seok; Peng, Weiyi; Jin, Lingtao; Ying, Mingyao; Rosenthal, Liana S.; Nauen, David W.; Pantelyat, Alex; Kaur, Mahima; Irene, Kezia; Shi, Liuhua; Feleke, Rahel; Garcia-Ruiz, Sonia; Ryten, Mina; Dawson, Valina L.; Dominici, Francesca; Weber, Rodney J.; Zhang, Xuan; Liu, Pengfei; Dawson, Ted M.; Han, Shizhong; Mao, Xiaobo
作者单位：Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Columbia University; Johns Hopkins University; Johns Hopkins Medicine; University System of Georgia; Georgia Institute of Technology; University of Houston System; University of Houston; University of Texas System; University of Texas at San Antonio; Johns Hopkins University; Johns Hopkins Medicine; Harvard University; Harvard T.H. Chan School of Public Health; Vertex Pharmaceuticals; Imperial College London; University of Cambridge; University of Cambridge; University of London; University College London; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; University of California System; University of California Merced; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Tianjin University of Science & Technology
摘要：Evidence links air pollution to dementia, yet its role in Lewy body dementia (LBD) remains unclear. In this work, we showed in a cohort of 56.5 million individuals across the United States that fine particulate matter (PM2.5) exposure raises LBD risk. Mechanistically, we found that PM2.5 exposure led to brain atrophy in wild-type mice, an effect not seen in alpha-synuclein (alpha Syn)-deficient mice. PM2.5 exposure generated a highly pathogenic alpha Syn strain, PM2.5-induced preformed fibril ...
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作者：Cohen, Jon
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作者：Valero, Manuel; Abad-Perez, Pablo; Gallardo, Andrea; Picco, Marta; Garcia-Hernandez, Raquel; Brotons, Jorge; Martinez-Felix, Anel; Machold, Robert; Rudy, Bernardo; Buzsaki, Gyorgy
作者单位：New York University; Hospital del Mar Research Institute; Hospital del Mar; Universidad CEU Cardenal Herrera; Consejo Superior de Investigaciones Cientificas (CSIC); New York University; New York University; New York University
摘要：Identifying the computational roles of different neuron families is crucial for understanding neural networks. Most neural diversity is embodied in various types of gamma-aminobutyric acid-mediated (GABAergic) interneurons, grouped into four major families. We collected datasets of opto-tagged neurons from all four families, along with excitatory neurons, from both the neocortex and hippocampus. The physiological features of these neurons were used to train a machine learning classifier, which...
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作者：Brinkmann, Kerstin; Mcarthur, Kate; Malelang, Shezlie; Gibson, Leonie; Tee, Annli; Elahee Doomun, Sheik Nadeem; Rowe, Caitlin L.; Arandjelovic, Philip; Marchingo, Julia M.; D'Silva, Damian; Bachem, Annabell; Monard, Simon; Whelan, Lauren G.; Dewson, Grant; Putoczki, Tracy L.; Bouillet, Philippe; Fu, Nai Yang; Brown, Kristin K.; Kueh, Andrew J.; Wimmer, Verena C.; Herold, Marco J.; Thomas, Tim; Voss, Anne K.; Strasser, Andreas
作者单位：Walter & Eliza Hall Institute; University of Melbourne; Monash University; University of Melbourne; University of Melbourne; Peter Doherty Institute; National University of Singapore; Peter Maccallum Cancer Center; University of Melbourne; Peter Maccallum Cancer Center; University of Melbourne; La Trobe University; Olivia Newton-John Cancer Research Institute; La Trobe University
摘要：The anti-apoptotic protein MCL-1 (myeloid cell leukemia-1) is essential for embryogenesis and the survival of many cell types that tolerate loss of its relatives, BCL-XL and BCL-2. Apoptosis-unrelated roles of MCL-1 in metabolism may contribute to this requirement, although their relevance for embryogenesis and postnatal life remains unclear. We hypothesized that BCL-XL and BCL-2 may substitute MCL-1's anti-apoptotic but not its apoptosis-unrelated functions. Replacing MCL-1 with BCL-XL or BCL...
