Cooperative actions of interneuron families support the hippocampal spatial code

• 成果类型: Article
• 署名作者: Valero, Manuel; Abad-Perez, Pablo; Gallardo, Andrea; Picco, Marta; Garcia-Hernandez, Raquel; Brotons, Jorge; Martinez-Felix, Anel; Machold, Robert; Rudy, Bernardo; Buzsaki, Gyorgy
• 署名单位: New York University; Hospital del Mar Research Institute; Hospital del Mar; Universidad CEU Cardenal Herrera; Consejo Superior de Investigaciones Cientificas (CSIC); New York University; New York University; New York University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8075; 1095-9203
• DOI: 10.1126/science.adv5638
• 发表日期: 2025-09-04
• 页码: eadv5638
• 关键词: transcriptomic cell-types; pyramidal cells; immunoreactive interneurons; dendritic inhibition; place cells; DYNAMICS; memory; reactivation; architecture; INFORMATION

摘要

Identifying the computational roles of different neuron families is crucial for understanding neural networks. Most neural diversity is embodied in various types of gamma-aminobutyric acid-mediated (GABAergic) interneurons, grouped into four major families. We collected datasets of opto-tagged neurons from all four families, along with excitatory neurons, from both the neocortex and hippocampus. The physiological features of these neurons were used to train a machine learning classifier, which subsequently inferred specific interneuron families in large-scale recordings. This combined approach enabled the reconstruction of synaptic connectivity motifs across interneuron family members. We further showed that these motifs differentially control the place field features of pyramidal neurons. Our findings attribute a prominent role to interneurons in the formation of a flexible cognitive map.