6764期

最新文章

• What's on Her Mind: The Mental Workload of Family Life AI翻译
  作者：Ruppanner, Leah
  作者单位：University of Melbourne; University of Melbourne
• Tandem sustainability AI翻译
  作者：Cortes, Emiliano
  作者单位：University of Munich
• Do inhibitory interneurons encode information or just keep the rhythm? AI翻译
  作者：Craig, Michael T.; Gonzalez-Rueda, Ana
  作者单位：University of Glasgow
• Resistin-like molecule γ attacks cardiomyocyte membranes and promotes ventricular tachycardia AI翻译
  作者：Kumowski, Nina; Pabel, Steffen; Grune, Jana; Momin, Noor; Ninh, Van K.; Stengel, Laura; Mentkowski, Kyle I.; Iwamoto, Yoshiko; Zheng, Yi; Lee, I-Hsiu; Matthias, Jessica; Wirth, Jan O.; Pulous, Fadi E.; Seung, Hana; Paccalet, Alexandre; Muse, Charlotte G.; Ting, Kenneth K. Y.; Delgado, Paul; Lewis, Andrew J. M.; Kaushal, Vaishali; Kreso, Antonia; Brown, Dennis; Hayat, Sikander; Kramann, Rafael; Swirski, Filip K.; Naxerova, Kamila; Propheter, Daniel C.; Hooper, Lora V.; Moskowitz, Michael A.; King, Kevin R.; Rosenthal, Nadia; Hulsmans, Maarten; Nahrendorf, Matthias
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Regensburg; University of California System; University of California San Diego; Kerckhoff Clinic; University of Oxford; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; RWTH Aachen University; Erasmus University Rotterdam; Erasmus MC; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Harvard University; Harvard Medical School; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; Howard Hughes Medical Institute; University of Texas Southwestern Medical Center; Jackson Laboratory; Imperial College London; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Wurzburg
  摘要：Ventricular tachycardia disrupts the heart's coordinated pump function, leading to sudden cardiac death. Neutrophils, which are recruited in high numbers to the ischemic myocardium, promote these arrhythmias. Comparing neutrophils with macrophages, we found that resistin-like molecule gamma (Retnlg or RELM gamma) was the most differentially expressed gene in mouse infarcts. RELM gamma is part of a pore-forming protein family that defends the host against bacteria by perforating their membranes...
• Epithelial tension controls intestinal cell extrusion AI翻译
  作者：Krueger, Daniel; Spoelstra, Willem Kasper; Mastebroek, Dirk Jan; Kok, Rutger N. U.; Wu, Shanie; Nikolaev, Mike; Bannier-Helaouet, Marie; Gjorevski, Nikolche; Lutolf, Matthias; van Es, Johan; van Zon, Jeroen; Tans, Sander J.; Clevers, Hans
  作者单位：Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW); Utrecht University; Utrecht University Medical Center; Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW); AMOLF; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Delft University of Technology; Utrecht University; Utrecht University Medical Center; Roche Holding
  摘要：Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In this study, we found instead that a local tug-of-war competition between contractile cells regulated extrusion in the intestinal epithelium. We combined quantitative live microscopy, optogenetic induction of tissue tension, genetic perturbation of myosin II activity, and local disruption of the basa...
• Unsteady ground AI翻译
  作者：Westbrook, Cherie
  作者单位：University of Saskatchewan
• Poking holes in the heart's rhythm AI翻译
  作者：Thorp, Edward B.
  作者单位：Northwestern University; Feinberg School of Medicine
• Catching tiny signals AI翻译
  作者：Goodson III, Theodore
  作者单位：University of Michigan System; University of Michigan
• Assess and protect jumbo flying squid AI翻译
  作者：Roa-Ureta, Ruben H.; Li, Gang; Chen, Xinjun; Ibanez, Christian M.; Belmar-Salinas, Karen; Ianelli, James N.; Gozzer-Wuest, Renato; Alonso-Poblacion, Enrique; Arkhipkin, Alexander I.; Mendo, Tania; Elias, Esteban; Peralta, Manuel; Escarabay, Teddy A.; Wiff, Rodrigo
  作者单位：Shanghai Ocean University; Universidad Andres Bello; Instituto de Fomento Pesquero (Valparaiso); National Oceanic Atmospheric Admin (NOAA) - USA; University of St Andrews; Pontificia Universidad Catolica de Chile
• Systematic discovery and engineering of synthetic immune receptors in plants AI翻译
  作者：Ngou, Bruno Pok Man; Wyler, Michele; Schmid, Marc W.; Suzuki, Takehiro; Albert, Markus; Dohmae, Naoshi; Kadota, Yasuhiro; Shirasu, Ken
  作者单位：RIKEN; University of Erlangen Nuremberg; University of Tokyo
  摘要：Plants deploy a diverse array of pattern recognition receptors (PRRs), which perceive microbe-associated molecular patterns to activate immune responses. Leucine-rich repeat receptor-like kinase subgroup XII (LRR-RLK-XII) represents one of the largest PRR families owing to lineage-specific diversification. Through bioinformatics and synthetic biology approaches, we characterized LRR-RLK-XIIs from 285 plant species and identified a receptor, SCORE, that perceives cold shock protein (CSP) peptid...