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作者：Jorgensen, Morten E.; Vequaud, Dominique; Wang, Yucheng; Andersen, Christian B.; Bayer, Micha; Box, Amanda; Braune, Katarzyna B.; Cai, Yuanyang; Chen, Fahu; Cuesta-Seijo, Jose A.; Dong, Haoran; Fincher, Geoffrey B.; Gojkovic, Zoran; Huang, Zihao; Jaegle, Benjamin; Kale, Sandip M.; Krsticevic, Flavia; Le Roux, Pierre-Marie; Lozier, Antoine; Lu, Qiongxian; Mascher, Martin; Murozuka, Emiko; Nakamura, Shingo; Simmelsgaard, Martin Ude; Pedas, Pai R.; Pin, Pierre A.; Podzimska-Sroka, Dagmara; Sato, Kazuhiro; Spannagl, Manuel; Rasmussen, Magnus W.; Russell, Joanne; Schreiber, Miriam; Thomsen, Hanne C.; Thomsen, Nina W.; Tulloch, Sophia; Voss, Cynthia; Skadhauge, Birgitte; Stein, Nils; Willerslev, Eske; Waugh, Robbie; Dockter, Christoph
作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Tibetan Plateau Research, CAS; Center for Excellence in Tibetan Plateau Earth Sciences (CETES), CAS; University of Cambridge; University of Copenhagen; University of Copenhagen; James Hutton Institute; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Lanzhou University; Adelaide University; University of Adelaide; University of Zurich; Leibniz Institut fur Pflanzengenetik und Kulturpflanzenforschung; National Agriculture & Food Research Organization - Japan; Okayama University; Setsunan University; Kazusa DNA Research Institute; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Murdoch University; Martin Luther University Halle Wittenberg; University of Dundee; Novo Nordisk; Aarhus University
摘要：Anthropogenic selection of grain traits such as dormancy has shaped the developmental trajectories of crops. In cereals, shortening dormancy provides rapid and even postharvest germination, but increases the risk of weather-induced preharvest sprouting, with yearly harvest losses beyond 1 billion dollars. Our understanding of how, why, when, and where cereal dormancy diversification arose is fragmentary. Here, we show in the founder crop barley (Hordeum vulgare) that dormancy is primarily regu...
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作者：Luo, Guoyan; Song, Jia; Fu, Yongbo; Jiang, Yuanjie; Gao, Yuan; Zhong, Zhixing; Li, Ling; Wei, Yong; Jia, Hao-Ran; Guo, Lu; Fu, Ting; Wu, Qin; Tan, Weihong
作者单位：Chinese Academy of Sciences; Zhejiang Cancer Hospital; Hangzhou Institute of Medicine, CAS; Hunan University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Xiamen University; Chinese Academy of Sciences; University of Science & Technology of China, CAS
摘要：Cell surface proteins are key disease biomarkers and therapeutic targets, yet high-throughput methods for aptamer discovery targeting these proteins in situ remain limited. We introduce single-cell perturbation-driven aptamer recognition and kinetics sequencing (SPARK-seq), a high-throughput platform integrating single-cell messenger RNA and aptamer sequencing with CRISPR-based surface protein perturbation. In a single experiment, SPARK-seq simultaneously mapped 5535 distinct aptamers to eight...
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作者：Yan, Yanyun; Rhodes, Jonathan R.
作者单位：Queensland University of Technology (QUT); Queensland University of Technology (QUT); University of Queensland
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作者：Campbell, Ian W.; Hullahalli, Karthik; Waldor, Matthew K.
作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Loyola University Chicago
摘要：Using genomic barcodes to trace bacterial lineages within a host reveals previously unobservable dynamics of infection, including the impact of infection bottlenecks, routes of bacterial dissemination, and patterns of within-host evolution. Barcoding introduces trackable diversity to otherwise isogenic bacterial populations. Comparing the barcodes within an inoculum to those within the host quantifies the founding population, which reveals the magnitude of population collapse caused by host bo...
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作者：Gopalan, Siddharth S.; Castoe, Todd A.
作者单位：University of Texas System; University of Texas Arlington
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作者：Mayer, Gunter
作者单位：University of Bonn; University of Bonn
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作者：Jiang, Mengping; Gu, Linfan; Ma, Mingyi; Li, Qin; Kao, Jonathan C.; Hong, Weizhe
作者单位：University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
摘要：Cooperation, the process through which individuals work together to achieve common goals, is fundamental to human and animal societies and increasingly critical in artificial intelligence (AI). In this study, we investigated cooperation in mice and AI systems, examining how they learn to actively coordinate their actions to obtain shared rewards. We identified key social behavioral strategies and decision-making processes in mice that facilitate successful cooperation. These processes are repr...
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作者：Agarwal, Gaurav; Antoszewski, Mateusz; Xie, Xueqin; Pershad, Yash; Arora, Uma P.; Poon, Chi-Lam; Lyu, Peng; Lee, Andrew J.; Guo, Chun-Jie; Ye, Tianyi; Norford, Laila Barakat; Neehus, Anna-Lena; Della Volpe, Lucrezia; Wahlster, Lara; Ranasinghe, Diyanath; Ho, Tzu-Chieh; Barlowe, Trevor S.; Chow, Arthur; Schurer, Alexandra; Taggart, James; Durham, Benjamin H.; Abdel-Wahab, Omar; Mcgraw, Kathy L.; Allan, James M.; Soldatov, Ruslan; Bick, Alexander G.; Kharas, Michael G.; Sankaran, Vijay G.
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Howard Hughes Medical Institute; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Memorial Sloan Kettering Cancer Center; Vanderbilt University; Memorial Sloan Kettering Cancer Center; Harvard University; Harvard Medical School; Newcastle University - UK; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; Harvard University
摘要：Somatic mutations that increase the fitness of hematopoietic stem cells (HSCs) drive their expansion in clonal hematopoiesis (CH) and predispose individuals to blood cancers. Population variation in the growth rate and potential of mutant clones suggests that genetic factors may confer resilience against CH. Here, we identified a noncoding regulatory variant, rs17834140-T, that protects against CH and myeloid malignancies by selectively down-regulating the RNA-binding protein MSI2 in HSCs. By ...
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作者：Rogers, Adam
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作者：Werner, Francisco
作者单位：National Oceanic Atmospheric Admin (NOAA) - USA
