Postdomestication selection of MKK3 shaped seed dormancy and end-use traits in barley

• 成果类型: Article
• 署名作者: Jorgensen, Morten E.; Vequaud, Dominique; Wang, Yucheng; Andersen, Christian B.; Bayer, Micha; Box, Amanda; Braune, Katarzyna B.; Cai, Yuanyang; Chen, Fahu; Cuesta-Seijo, Jose A.; Dong, Haoran; Fincher, Geoffrey B.; Gojkovic, Zoran; Huang, Zihao; Jaegle, Benjamin; Kale, Sandip M.; Krsticevic, Flavia; Le Roux, Pierre-Marie; Lozier, Antoine; Lu, Qiongxian; Mascher, Martin; Murozuka, Emiko; Nakamura, Shingo; Simmelsgaard, Martin Ude; Pedas, Pai R.; Pin, Pierre A.; Podzimska-Sroka, Dagmara; Sato, Kazuhiro; Spannagl, Manuel; Rasmussen, Magnus W.; Russell, Joanne; Schreiber, Miriam; Thomsen, Hanne C.; Thomsen, Nina W.; Tulloch, Sophia; Voss, Cynthia; Skadhauge, Birgitte; Stein, Nils; Willerslev, Eske; Waugh, Robbie; Dockter, Christoph
• 署名单位: Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Tibetan Plateau Research, CAS; Center for Excellence in Tibetan Plateau Earth Sciences (CETES), CAS; University of Cambridge; University of Copenhagen; University of Copenhagen; James Hutton Institute; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Lanzhou University; Adelaide University; University of Adelaide; University of Zurich; Leibniz Institut fur Pflanzengenetik und Kulturpflanzenforschung; National Agriculture & Food Research Organization - Japan; Okayama University; Setsunan University; Kazusa DNA Research Institute; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Murdoch University; Martin Luther University Halle Wittenberg; University of Dundee; Novo Nordisk; Aarhus University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8075; 1095-9203
• DOI: 10.1126/science.adx2022
• 发表日期: 2026-01-01
• 页码: 90-95
• 关键词: QTL; EVOLUTION; insights

摘要

Anthropogenic selection of grain traits such as dormancy has shaped the developmental trajectories of crops. In cereals, shortening dormancy provides rapid and even postharvest germination, but increases the risk of weather-induced preharvest sprouting, with yearly harvest losses beyond 1 billion dollars. Our understanding of how, why, when, and where cereal dormancy diversification arose is fragmentary. Here, we show in the founder crop barley (Hordeum vulgare) that dormancy is primarily regulated through a mosaic of locus haplotypes comprising copy number variation and inherent kinase activity of Mitogen-activated protein kinase kinase 3 (MKK3). We provide evidence supporting the historical selection of specific MKK3 haplotypes that shaped dormancy levels according to changing climatic pressures and outline a genetic framework for breeders to balance grain dormancy and preharvest sprouting avoidance.