6781期

最新文章

• Art historians turn to biology AI翻译
  作者：Stone, Richard
• Tree bark microbes for climate management AI翻译
  作者：Gauci, Vincent
  作者单位：University of Birmingham; University of Birmingham; University of Birmingham
• Fake data from trial sites ruin studies, drug firms say AI翻译
  作者：Piller, Charles
• The molecular basis of the binding and specific activation of rhizobial NodD by flavonoids AI翻译
  作者：Ruan, Yiting; Dong, Shangzhi; Jiang, Suyu; Wang, Yisheng; Wu, Xiaotan; Zhuang, Yuxin; Wu, Wenjuan; East, Alison K.; Xu, Ping; Poole, Philip S.; Zhang, Yu; Murray, Jeremy D.
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; University of Oxford; Shanghai Normal University
  摘要：The specific partnership between legumes and rhizobia relies on a chemical dialogue. Plant flavonoids activate the bacterial transcription factor NodD, which triggers production of Nod factors that are recognized by the plant. Structural studies of the Pisum sativum (pea) symbiont Rhizobium leguminosarum NodD revealed two pockets that are essential for its activation by flavonoids. Comparative studies with NodD1 of Sinorhizobium medicae, the symbiont of Medicago truncatula, revealed that this ...
• Iran's ancient Hyrcanian forests on fire AI翻译
  作者：Mousazadehgavan, Milad; Madani, Kaveh
  作者单位：Liverpool John Moores University
• New conflicts erupt over key virus database AI翻译
  作者：Kupferschmidt, Kai
• IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation AI翻译
  作者：Park, Jung Won; Kwak, Jiehoon; Kim, Keon-Woo; Jung, Saehoon; Nam, Chang Hyun; Kim, Hyun Jung; Lee, Sang Mee; Choi, Chanho; Ahn, Yongjin; Park, Ji-Hyung; Yoo, Jihwan; Shim, Jin-Kyoung; Cho, Hye Joung; Kim, Eui-Hyun; Kim, Chungyeul; Ahn, Sangjeong; Pusch, Stefan; von Deimling, Andreas; Chang, Jong Hee; Kim, Se Hoon; Kim, Hoon; Ju, Young Seok; Kang, Seok-Gu; Lee, Jeong Ho
  作者单位：Korea Advanced Institute of Science & Technology (KAIST); Korea University; Korea University Medicine (KU Medicine); Yonsei University; Severance Hospital; Yonsei University Health System; Yonsei University; Severance Hospital; Yonsei University Health System; Yonsei University; Severance Hospital; Yonsei University Health System; Korea University; Korea University Medicine (KU Medicine); Korea University; Korea University Medicine (KU Medicine); Korea University; Korea University Medicine (KU Medicine); Korea University; Korea University Medicine (KU Medicine); Ruprecht Karls University Heidelberg; Helmholtz Association; German Cancer Research Center (DKFZ); Yonsei University; Yonsei University Health System; Yonsei University; Yonsei University Health System; Sungkyunkwan University (SKKU); Yonsei University; Yonsei University Health System
  摘要：Identifying the cell of origin that harbors an initial driver mutation is key to understanding tumor evolution and for the development of new treatments. For isocitrate dehydrogenase (IDH)-mutant gliomas, the most common malignant primary brain tumor in young adults, the cell of origin is currently poorly understood. We conducted deep sequencing on 142 tissues from 70 individuals comprising tumors, peritumoral cortex or subventricular zones, and blood. Low-level IDH mutations were found in the...
• Access to four-membered cyclic sulfinamides by energy transfer catalysis AI翻译
  作者：Zhai, Di; Williams, Benedict A.; Pantaine, Loic R. E.; Chen, Yiding; Willis, Michael C.
  作者单位：University of Oxford
  摘要：Synthetic transformations that advance through excited states proceed by unconventional mechanistic pathways and deliver products not accessible using ground-state chemistry. The breadth of these synthetically valuable transformations is constrained by the range of molecules-and particularly the functional groups-that can deliver productive excited states, with most methods using the same functional groups that were defined more than 100 years ago. In this work, we show that N-silyl sulfinylam...
• Did the illicit fentanyl trade experience a supply shock?: A synthesis of government and social media data suggests a disruption, possibly tied to events in China AI翻译
  作者：Vangelov, Kasey; Humphreys, Keith; Caulkins, Jonathan P.; Pollack, Harold; Pardo, Bryce; Reuter, Peter
  作者单位：University System of Maryland; University of Maryland College Park; Stanford University; Carnegie Mellon University; University of Chicago; University System of Maryland; University of Maryland College Park
• Dogs with a large vocabulary of object labels learn new labels by overhearing like 1.5-year-old infants AI翻译
  作者：Dror, Shany; Miklosi, Adam; Morvai, Boglarka; Nastase, Andreea-Silvia; Fugazza, Claudia
  作者单位：University of Veterinary Medicine Vienna; Eotvos Lorand University; MTA-ELTE Comparative Ethology Research Group; Eotvos Lorand University
  摘要：Children as young as 18 months can acquire novel words by overhearing third-party interactions. Demonstrating similar learning processes in nonhuman species would indicate that the social-cognitive skills supporting this process are not exclusively human but may have evolved, or can develop, in other species, offering valuable insights into the origins of language-related cognition. In this study, we demonstrated that a small group of Gifted Word Learner dogs, which possess an extensive vocabu...