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作者：Boness, Cassandra L.
作者单位：University of New Mexico; University of New Mexico
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作者：Heins, Christopher; Korber, Lukas; Kim, Joo-Von; Devolder, Thibaut; Mentink, Johan H.; Kakay, Attila; Fassbender, Jurgen; Schultheiss, Katrin; Schultheiss, Helmut
作者单位：Helmholtz Association; Helmholtz-Zentrum Dresden-Rossendorf (HZDR); Technische Universitat Dresden; Radboud University Nijmegen; Institut Polytechnique de Paris; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Ecole Polytechnique
摘要：Driving condensed matter systems with periodic electromagnetic fields can result in exotic states not found in equilibrium. Termed Floquet engineering, such periodic driving applied to electronic systems can induce topological band structures and control spin interactions. In this study, we present a class of Floquet states in a magnetic vortex that arise from nonlinear interactions between the vortex core and microwave magnons. Floquet bands emerge through the periodic oscillation of the core...
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作者：Niu, Yuan; Chen, Yu; Zhou, Meng; Zeng, Huihui; Wang, Ke; Yu, Peiyuan; Dong, Zhe
作者单位：Southern University of Science & Technology; Southern University of Science & Technology
摘要：Pericyclic reactions transform simple precursors into architecturally complex products with exquisite stereocontrol, making them central tools in synthesis. Here, we report a class of pericyclic reactions, called triatropic rearrangements, wherein three sigma-bonds are broken concomitantly with the formation of two sigma-bonds and one pi-bond, all in a single transition state. Within this mechanistic manifold, carbon-oxygen bonds in epoxides are stereoselectively converted into carbon-carbon b...
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作者：Stahl, Ronit Y.
作者单位：University of California System; University of California Berkeley
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作者：Jia, Yinjun; Gao, Bowen; Tan, Jiaxin; Zheng, Jiqing; Hong, Xin; Zhu, Wenyu; Tan, Haichuan; Xiao, Yuan; Tan, Liping; Cai, Hongyi; Huang, Yanwen; Deng, Zhiheng; Wu, Xiangwei; Jin, Yue; Yuan, Yafei; Tian, Jiekang; He, Wei; Ma, Weiying; Zhang, Yaqin; Liu, Lei; Yan, Chuangye; Zhang, Wei; Lan, Yanyan
作者单位：Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Peking University; Tsinghua University; Beijing Academy of Artificial Intelligence
摘要：Recent breakthroughs in protein structure prediction have opened new avenues for genome-wide drug discovery, yet existing virtual screening methods remain computationally prohibitive. We present DrugCLIP, a contrastive learning framework that achieves ultrafast and accurate virtual screening, up to 10 million times faster than docking, while consistently outperforming various baselines on in silico benchmarks. In wet-lab validations, DrugCLIP achieved a 15% hit rate for norepinephrine transpor...
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作者：Thakur, M. P.
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作者：Leung, Pok Man; Jeffrey, Luke C.; Bay, Sean K.; Gomez-Alvarez, Paula; Hall, Montgomery; Johnston, Scott G.; Dittmann, Johannes; Deschaseaux, Elisabeth; Hopkins, Billie; Haskell, Jasmine; Jirapanjawat, Thanavit; Hutchinson, Tess F.; Coleman, Nicholas V.; Dong, Xiyang; Maher, Damien T.; Greening, Chris
作者单位：Monash University; Monash University; Southern Cross University; Macquarie University; Macquarie University; ARC Centre of Excellence in Synthetic Biology; Third Institute of Oceanography, Ministry of Natural Resources; Ministry of Natural Resources of the People's Republic of China
摘要：Recent studies suggest that microbes inhabit tree bark, yet little is known about their identities, functions, and environmental roles. Here we reveal, through gene-centric and genome-resolved metagenomics, that the bark of eight common Australian tree species hosts abundant and specialized microbial communities. The predominant bacteria are hydrogen-cycling facultative anaerobes adapted to dynamic redox and substrate conditions. Furthermore, bark-associated methanotrophs are abundant and can ...
